NLRP10/Pynod/NALP10 Antibody

Images

 
Western Blot: NLRP10/Pynod/NALP10 Antibody [NBP1-76291] - Human brain tissue lysate with NALP10 antibody at 1 ug/mL.
Immunohistochemistry: NLRP10/Pynod/NALP10 Antibody [NBP1-76291] - Immunohistochemistry of NALP10 in human brain tissue with NALP10 antibody at 10 ug/mL.
Immunofluorescence: NLRP10/Pynod/NALP10 Antibody [NBP1-76291] - Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, ICC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

NLRP10/Pynod/NALP10 Antibody Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human NALP10. The immunogen is located within the first 50 amino acids of NALP10.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NLRP10
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 20 ug/ml
  • Immunocytochemistry 20 ug/ml
Control Peptide
NLRP10/Pynod/NALP10 Peptide (NBP1-76291PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for NLRP10/Pynod/NALP10 Antibody

  • CLR11.1
  • NACHT, leucine rich repeat and PYD containing 10
  • NALP10
  • NALP10Pynod
  • NLR family, pyrin domain containing 10
  • NLRP10
  • NOD8
  • NOD8Nucleotide-binding oligomerization domain protein 8
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 10
  • PAN5
  • Pynod
  • PYNODNACHT, LRR and PYD domains-containing protein 10

Background

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1beta, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1beta processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol NLRP10
Entrez
Uniprot