NKX3.1 Antibody (738907) [Alexa Fluor® 750]

• Reactivity: Mu
• Applications: ICC/IF
• Clone: 738907
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 750

NKX3.1 Antibody (738907) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant mouse NKX3.1
  Met1-Pro124 (predicted)
  Accession # P97436
• Specificity: Detects mouse NKX3.1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) NKX3.1 or rhNKX6.1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKX3.1 Antibody (738907) [Alexa Fluor® 750]

• BAPX2
• BAPX2homeobox protein Nkx-3.1
• Homeobox protein NK-3 homolog A
• NK homeobox (Drosophila), family 3, A
• NK3 homeobox 1
• NK3 transcription factor homolog A
• NK3 transcription factor related, locus 1 (Drosophila)
• NK3 transcription factor related, locus 1
• NKX3.1
• NKX3.1NKX3
• NKX3-1
• NKX3A
• NKX3ANK homeobox, family 3, A

Background

NKX3.1 (Homeobox protein NK-3 homolog A) is a 38 kDa member of the NK-3 homeobox family of transcription factors. It is expressed in mouse palatine and prostatic epithelium, and appears to be regulated by both testosterone and estrogen. NKX3.1 apparently promotes prostate gland development, and acts as a tumor-suppressor/transcriptional repressor by interacting with HDAC-1, potentially inducing IGFBP-3 secretion, and increasing p53 acetylation and half-life. Mouse NKX3.1 is 237 amino acids (aa) in length. It contains a DNA-binding homeodomain (aa 125-184) and undergoes ubiquitination at multiple sites. Over aa 1-124, mouse NKX3.1 shares 77% and 48% aa identity with rat and human NKX3.1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.