NK3R/TACR3/Neurokinin B Receptor Antibody


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Product Details

Reactivity Mu, Rt, Gp, Sh, Hu(-)Species Glossary
Applications ICC/IF, IHC, IHC-Fr, IHC-FrFl, WB (-)

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NK3R/TACR3/Neurokinin B Receptor Antibody Summary

A synthetic peptide at the C-terminus of rat Neurokinin B Receptor, conjugated to bovine thyroglobulin. [UniProt# P16177]
In immunohistochemical experiments staining of the neuronal cell bodies and fibers is seen and staining is believed to be localized to the plasma membrane.
NB300-102 is specific to the NK-3 receptor. Specificity was verified by the localization of immunohistochemical staining as well as pre-absorption studies with NK-3 peptide. (1)
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  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry Free-Floating
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
Use in Immunohistochemistry- free floating reported in scientific literature (PMID 25496429). Use in Immunohistochemistry frozen reported in scientific literature (PMID: 30565563). It is not useful for Western blot.
Read Publications using
NB300-102 in the following applications:

Reactivity Notes

Rat, mouse and guinea pig in brain, spinal cord and ileum. Customer feedback suggests that human reactivity is negative. Sheep reactivity reported in scientific literature (PMID: 19912479).

Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Whole antisera
0.1% Sodium Azide

Alternate Names for NK3R/TACR3/Neurokinin B Receptor Antibody

  • Neurokinin B Receptor
  • neurokinin beta receptor
  • Neuromedin-K Receptor
  • NK-3 receptor
  • NK3R
  • NK-3R
  • NK3RMGC148061
  • NKR
  • TAC3R
  • TAC3RL
  • tachykinin receptor 3MGC148060
  • TACR3


Neurokinins belong to tachykinin family of signalling peptides and the best known human tachykinins are neurokinin B, (encoded by TAC3) and substance P (SP) as well as neurokinin A (NKA), (both encoded by the same TAC1 gene). Neurokinins are widely expressed in CNS, and exert effects on target cells through action at three closely related Gq-coupled neurokinin receptors: NK1R, NK2R, NK3R: encoded in humans by TACR1, TACR2 and TACR3 respectively. None of these neurokinin receptors are entirely specific for SP, NKA or NKB, however, they do show some degree of selectivity, and TACR3/NK3R (neurokinin B receptor or neuromedin-K receptor) behaves as cognate receptor for NKB in vivo. NK3R are predominantly expressed in neurons of PNS/CNS and in particular, in many of forebrain areas, such as frontal, parietal and cingulate cortices, and basal ganglia structures implicated in psychiatric disease states, and can modulate monoaminergic and amino acid neurotransmission within these structures. Neurokinin B and NK3R are also expressed in placenta, kidney, skeletal muscle and lung tissues, and had been implicated in diverse processes, including water homeostasis, pulmonary inflammation, cognition, and preeclampsia.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu, Rt
Applications: IHC
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Applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB
Species: Hu, Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, WB
Species: Hu, Mu, Rt
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Species: Hu
Applications: Block, CyTOF-ready, Flow
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Applications: IHC, WB
Species: Hu
Applications: CyTOF-ready, Flow
Species: Hu
Applications: BA
Species: Hu, Mu
Applications: Flow-IC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
Species: Hu
Applications: CyTOF-ready, ELISA, Flow, ICC/IF, IHC, IHC-P, PA, WB
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
Species: Bv, Gt, Hu, Po
Applications: IHC, IHC-P
Species: Hu, Mu, Rt
Applications: Flow, ICC/IF, IF, IHC, IHC-P
Species: Hu
Applications: Block, CyTOF-reported, Flow
Species: Hu
Applications: BA
Species: Hu
Applications: CyTOF-ready, Flow, WB
Species: Hu
Applications: CostimT, CyTOF-ready, Flow, Neut, WB
Species: Hu, Rt
Applications: Flow-CS, Flow, ICC/IF, IHC, IHC-P, Simple Western

Publications for NK3R/TACR3/Neurokinin B Receptor Antibody (NB300-102)(34)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Guinea Pig, Sheep.

We have publications tested in 5 applications: ICC, ICC/IF, IHC, IHC-Fr, IHC-FrFl.

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Showing Publications 1 - 10 of 34. Show All 34 Publications.
Publications using NB300-102 Applications Species
Edvinsson JC, Reducha PV, Sheykhzade M et al. Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain Molecular pain Dec 13 2021 [PMID: 34898306] (IHC-Fr, Rat) IHC-Fr Rat
Lopez, J A, Bowdridge, E C Et al. Morphological and functional evidence for sexual dimorphism in neurokinin B signalling in the retrochiasmatic area of sheep. J Neuroendocrinol Jul 1 2020 [PMID: 32572994] (IHC, Mouse) IHC Mouse
Yin C, Ishii T, Kaneda M Two Types of Cl Transporters Contribute to the Regulation of Intracellular Cl Concentrations in ON- and OFF-type Bipolar Cells in the Mouse Retina Neuroscience Jun 10 2020 [PMID: 32531472] (IHC, Mouse) IHC Mouse
Goodman R L, He W et al. Evidence That the LH Surge in Ewes Involves Both Neurokinin B-Dependent and -Independent Actions of Kisspeptin. Endocrinology Jan 12 2019 [PMID: 31599937] (IHC, Sheep) IHC Sheep
Sakata D, Uruno T et al. Selective role of neurokinin B in IL-31-induced itch response in mice. J Allergy Clin Immunol Jan 10 2019 [PMID: 31405606] (IHC, Mouse) IHC Mouse
Hsu YW, Morton G, Guy EG et al. Dorsal Medial Habenula Regulation of Mood-Related Behaviors and Primary Reinforcement by Tachykinin-Expressing Habenula Neurons eNeuro 2016 Aug 02 [PMID: 27482535]
Hether S, Misono K, Lessard A. The neurokinin-3 receptor (NK3R) antagonist SB222200 prevents the apomorphine-evoked surface but not nuclear NK3R redistribution in dopaminergic neurons of the rat ventral tegmental area. Neuroscience 2013 May 11 [PMID: 23673279] (Rat) Rat
Nivison-Smith L, Sun D, Fletcher EL et al. Mapping kainate activation of inner neurons in the rat retina. J Comp Neurol 2013 Aug 1 [PMID: 23348566] (Rat) Rat
Chen SL, Liu YG, Zhou YT et al. Morphological and Functional Evidence of Sexual Dimorphism in the Retrochiasmatic Area Population of NK3R-containing Neurons in Sheep Thesis (IHC-FrFl, Sheep) IHC-FrFl Sheep
Fergani C, Leon S, Padilla SL et al. NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice Elife Dec 19 2018 [PMID: 30565563] (IHC-Fr, Mouse) IHC-Fr Mouse
Show All 34 Publications.

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ICC/IF Video Protocol

FAQs for NK3R/TACR3/Neurokinin B Receptor Antibody (NB300-102). (Showing 1 - 1 of 1 FAQs).

  1. I was wondering about the Rabbit polyclonal antibody to Neurokinin-3-receptor, catalog #NB300-102. I am wondering about its information on the immunogen. You state that, NB300-102 was raised against a synthetic peptide at the c-terminus of rat Nk-3 conjugated to bovine thyroglobulin. I was wondering if you could tell me exactly which amino acids that this does correspond to? I am interested in comparing it to the Rabbit anti-Nk3R used for western blot, catalog#R-103-100, which states that it corresponds to the aa:434-452 of the absolute c-terminal of rat Nk3R protein.
    • The immunogen for this antibody is between amino acids 375 and 452 of rat NK3R. Any further information regarding the immunogen is considered proprietary.

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Gene Symbol TACR3