Niemann-Pick type C1 Like-1 Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, Mu, Rt, PoSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

Niemann-Pick type C1 Like-1 Antibody [DyLight 550] Summary

Immunogen
A synthetic peptide made to an internal region of rat Niemann-Pick type C1 Like-1 (between residues 1000-1100). [UniProt# Q6T3U3]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NPC1L1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Niemann-Pick type C1 Like-1 antibody is useful for Immunohistochemistry paraffin embedded sections and Western blot. In Western blot a band is observed at ~140 kDa representing NPC1L1, and a nonspecific band may be observed at ~45 kDa depending on the lysate used. Use in Electron Microscopy reported in scientific literature (PMID: 21051527)

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
140 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, rat, pig and mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Niemann-Pick type C1 Like-1 Antibody [DyLight 550]

  • Niemann-Pick C1-like protein 1
  • NPC1 (Niemann-Pick disease, type C1, gene)-like 1
  • NPC11L1

Background

Dietary consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, which factor into the risk of coronary heart disease. Niemann-Pick type C1 Like 1 protein (NPC1L1 or NPC3) is enriched in the small intestine and is found in the brush border membrane of enterocytes. It plays a critical role in absorption of intestinal cholesterol.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB400-127B
DyLight 488 Labeled NB400-127G
DyLight 650 Labeled NB400-127C
HRP Labeled NB400-127H

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Bioinformatics Tool for Niemann-Pick type C1 Like-1 Antibody (NB400-127R)

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Bioinformatics

Gene Symbol NPC1L1