NGFR/TNFRSF16/p75NTR Antibody (2F1C2) [PE]

• Reactivity: Hu
• Applications: WB, ELISA, Flow, ICC/IF
• Clone: 2F1C2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PE

NGFR/TNFRSF16/p75NTR Antibody (2F1C2) [PE] Summary

• Immunogen: Purified recombinant fragment of human p75NTR/NGF Receptor expressed in E. coli. [UniProt# P08138]
• Localization: Membrane; Single-pass type I membrane protein.
• Isotype: IgG2 Alpha
• Clonality: Monoclonal
• Host: Mouse
• Gene: NGFR
• Purity: Ascites

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.
• Theoretical MW: 45 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Ascites

Alternate Names for NGFR/TNFRSF16/p75NTR Antibody (2F1C2) [PE]

• CD271 antigen
• CD271
• Gp80-LNGFR
• member 16
• nerve growth factor receptor
• NGF R
• NGF receptor
• NGFR
• p75 ICD
• p75 NTR
• TNFRSF16
• TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16)
• tumor necrosis factor receptor superfamily member 16

Background

p75NTR/NGF Receptor, also known as Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. p75NTR/NGF Receptor plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of p75NTR/NGF Receptor by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to p75NTR/NGF Receptor activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NGFR