NGFR/TNFRSF16/p75NTR Products

Description

p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.

Bioinformatics

Uniprot	NM_002507 Human NP_002498 Human NP_002498.1 Human P07174 Rat P08138 Human
Product By Gene ID	4804
Alternate Names	CD271 antigen CD271 Gp80-LNGFR member 16 nerve growth factor receptor NGF receptor p75 ICD TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16) tumor necrosis factor receptor superfamily member 16

Research Areas for NGFR/TNFRSF16/p75NTR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Neuronal Cell Markers
Neuronal Stem Cell Markers
Neuroscience
Stem Cell Markers