NCOA6 Antibody

Immunohistochemistry:[NBP3-29243]-Detection of human ASC2 by immunohistochemistry. Sample: FFPE section of human stomach. Antibody: Affinity purified rabbit anti-ASC2.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

NCOA6 Antibody Summary

• Immunogen: Between 2000 and C-term
• Assay Type: [Assay Type]
• Sample Volume: [Sample Volume]
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NCOA6
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-buffered Saline 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Affinity purified

Alternate Names for NCOA6 Antibody

• Activating signal cointegrator 2
• AIB3NRC RAP250
• Amplified in breast cancer protein 3
• ASC-2
• Cancer-amplified transcriptional coactivator ASC-2
• KIAA0181PPAR-interacting protein
• NRCamplified in breast cancer-3 protein
• nuclear receptor coactivator 6
• Nuclear receptor coactivator RAP250
• Nuclear receptor-activating protein, 250 kDa
• peroxisome proliferator-activated receptor interacting protein
• PRIPPeroxisome proliferator-activated receptor-interacting protein
• RAP250Thyroid hormone receptor-binding protein
• thyroid hormone receptor binding protein
• TRBPASC2activating signal cointegrator-2

Background

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NCOA6