NAIP Antibody (541609) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 541609
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

NAIP Antibody (541609) [Alexa Fluor® 750] Summary

• Immunogen: E.coli-derived recombinant human NAIP
  Asn923-Val1148
  Accession # Q13075
• Specificity: Detects human NAIP in Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) NAIP or rmNAIP2 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NAIP Antibody (541609) [Alexa Fluor® 750]

• baculoviral IAP repeat-containing 1
• BIRC1
• BIRC1baculoviral IAP repeat-containing protein 1
• FLJ18088
• FLJ42520
• FLJ58811
• NAIP
• Neuronal apoptosis inhibitory protein
• NLR family, apoptosis inhibitory protein
• NLR family, BIR domain containing 1
• NLRB1
• nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1
• psi neuronal apoptosis inhibitory protein
• psiNAIP

Background

Neuronal apoptosis inhibitory protein (NAIP; also Baculoviral IAP repeat-containing protein 1) is a 160 kDa member of the inhibitor of apoptosis family of proteins (also known as BIRC proteins). Human NAIP is 1403 amino acids (aa) in length.  It contains three distinct regions: an N-terminal cluster of three baculoviral inhibitory repeat (BIR) domains, a central nucleotide binding oligomerization domain (NOD), and a C-terminal leucine-rich repeat (LRR) domain.  Human NAIP shares 68% aa identity with mouse NAIP.  NAIP is expressed in motor neurons, but not in sensory neurons.  It is also expressed in the liver, placenta and to a lesser extent in the spinal cord.  NAIP prevents motor neuron apoptosis, and defects in NAIP have been found in individuals with spinal muscular atrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q13075()