NAIP Antibody (541609) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 541609
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

NAIP Antibody (541609) [Alexa Fluor® 700] Summary

• Immunogen: E.coli-derived recombinant human NAIP
  Asn923-Val1148
  Accession # Q13075
• Specificity: Detects human NAIP in Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) NAIP or rmNAIP2 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NAIP Antibody (541609) [Alexa Fluor® 700]

• baculoviral IAP repeat-containing 1
• BIRC1
• BIRC1baculoviral IAP repeat-containing protein 1
• FLJ18088
• FLJ42520
• FLJ58811
• NAIP
• Neuronal apoptosis inhibitory protein
• NLR family, apoptosis inhibitory protein
• NLR family, BIR domain containing 1
• NLRB1
• nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1
• psi neuronal apoptosis inhibitory protein
• psiNAIP

Background

Neuronal apoptosis inhibitory protein (NAIP; also Baculoviral IAP repeat-containing protein 1) is a 160 kDa member of the inhibitor of apoptosis family of proteins (also known as BIRC proteins). Human NAIP is 1403 amino acids (aa) in length.  It contains three distinct regions: an N-terminal cluster of three baculoviral inhibitory repeat (BIR) domains, a central nucleotide binding oligomerization domain (NOD), and a C-terminal leucine-rich repeat (LRR) domain.  Human NAIP shares 68% aa identity with mouse NAIP.  NAIP is expressed in motor neurons, but not in sensory neurons.  It is also expressed in the liver, placenta and to a lesser extent in the spinal cord.  NAIP prevents motor neuron apoptosis, and defects in NAIP have been found in individuals with spinal muscular atrophy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.