Myocilin Antibody (297817) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: IHC
• Clone: 297817
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

Myocilin Antibody (297817) [Janelia Fluor® 549] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Myocilin
  Arg33-Met504
  Accession # Q99972
• Specificity: Detects human Myocilin in direct ELISAs. In direct ELISAs, 75% cross-reactivity with recombinant mouse Myocilin is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: MYOC
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Myocilin Antibody (297817) [Janelia Fluor® 549]

• GLC1A
• GLC1Amyocilin
• GPOA
• JOAG
• JOAG1
• MYOC
• Myocilin
• myocilin, trabecular meshwork inducible glucocorticoid response
• TIGR
• TIGRmutated trabecular meshwork-induced glucocorticoid response protein
• Trabecular meshwork-induced glucocorticoid response protein

Background

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MYOC