Olfactomedin-1/Noelin-1 Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

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Olfactomedin-1/Noelin-1 Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Olfactomedin‑1/Noelin‑1
Ser2-Arg481
Accession # NP_062371
Specificity
Detects mouse Olfactomedin‑1/Noelin‑1 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
OLFM1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF4636 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Olfactomedin-1/Noelin-1 Antibody

  • AMY
  • AMYolfactomedin related ER localized protein
  • neuroblastoma protein
  • Neuronal olfactomedin-related ER localized protein
  • NOE1
  • NOE1noelin
  • NOEL1
  • NOELIN
  • NOELIN1
  • Noelin-1
  • OlfA
  • olfactomedin 1
  • Olfactomedin1
  • Olfactomedin-1
  • OLFM1
  • pancortin 1

Background

Olfactomedin‑1 (neuronal olfactomedin-related endoplasmic reticulum-localized-1), also known as Olfactomedin-1 or pancortin, is a 75 kDa secreted extracellular matrix glycoprotein expressed in the brain (1‑3). Alternate promoter usage and splicing creates four forms of Noelin (Noelin 1‑4) that are combinations of a common central region with alternate N- and C-termini (3, 4). Noelin-1 is the longest of the four isoforms, encoding a 16 amino acid (aa) signal sequence and a 469 aa mature protein with a coiled-coil region for multimerization and an olfactomedin-like domain. The shortest isoforms, Noelin-3 and -4, are truncated within the coiled-coil region and lack the olfactomedin-like domain (4). In the species tested, these isoforms appear to oppose actions of the longer isoforms (5). All isoforms are capable of forming homo‑ or heterodimers through cysteines in their common central region (2). The C‑terminus of Noelin-1 (mouse aa 482‑485) contains a putative endoplasmic reticulum retention sequence that has not been included in the R&D Systems protein (6). Mouse Noelin-1 (aa 17‑481) shares > 99%, 99%, 97%, 96% and 93% aa identity with corresponding regions of rat, human, opossum, chicken and Xenopus Noelin-1, respectively. In vivo expression patterns differ somewhat between species (1). In chick early development, Noelin-1 shows highest concentration in areas that produce neural crest cells and is produced by migrating neural crest cells (7). Overproduction of Noelin-1 prolongs neural crest cell formation (7). Noelin-1 is also expressed in mouse neural crest, but not frog (1‑3). All three species express Noelin-1 later in differentiating neural tissues in the spinal cord, brain and cranial ganglia (1‑3).

  1. Moreno, T.A. & M. Bronner-Fraser (2002) Mech. Dev. 119:121.
  2. Ando, K. et al. (2005) Neuroscience 133:947.
  3. Nagano, T. et al. (1998) Brain Res. Mol. Brain Res. 53:13.
  4. Danielson, P.E. et al. (1994) J. Neurosci. Res. 38:468.
  5. Moreno, T.A. & M. Bronner-Fraser (2005) Dev. Biol. 288:434.
  6. Moreno, T.A. & M. Bronner-Fraser (2001) Dev. Biol. 240:340.
  7. Barembaum, M. et al. (2000) Nat. Cell Biol. 2:219.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Olfactomedin-1/Noelin-1 Antibody (AF4636)(2)

We have publications tested in 2 confirmed species: Mouse, Chicken.

We have publications tested in 2 applications: BN-MS (Blue Native Gel- Mass S, WB.


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(1)
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Bioinformatics

Gene Symbol OLFM1
Entrez
Uniprot