MUC19 Antibody (876013)

MUC-19 was detected in immersion fixed paraffin-embedded sections of human salivary gland using Mouse Anti-Human MUC-19 Monoclonal Antibody (Catalog # MAB8245) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to mucosal cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

• Reactivity: Hu
• Applications: IHC
• Clone: 876013
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

MUC19 Antibody (876013) Summary

• Immunogen: E. coli-derived recombinant human MUC-19
  Lys5606-Gly5767
  Accession # Q7Z5P9
• Specificity: Detects human MUC-19 in direct ELISAs.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: MUC19
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 8-25 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C, as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
  • 6 months, -20 to -70 °C under sterile conditions after opening.
• Buffer: Supplied as a 0.2 μm filtered solution in PBS. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MUC19 Antibody (876013)

• MUC19
• MUC-19

Background

MUC-19 is a 6,254 amino acid member of the Mucin family of gel-forming glycoproteins.  MUC-19 is expressed in corneal epithelial cells in the eye, conjuctival goblet and epithelial cells and lacrimal gland cells as well as by mucous cells of the submandibular gland and submucosal gland of the trachea.  MUC-19 expression is reduced in patients with Sjogren syndrome (1,2). In a middle ear model of inflammatory response, MUC-19 is up-regulated in epithelial cells by exposure to cytokines including TNF-alpha, IL-1 beta, IL-5 and IL-8 (3).

 

1. Yu, D. et al. (2008) Exp Eye Res. 86 :403.
2. Chen, Y. et al. (2004) Am J Respir Cell Mol Biol 30:155.
3. Kerschner, J. et al. (2009) Glycoconj J. 26:1275.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MUC19
• Uniprot:
  • Q7Z5P9()