mtTFA Antibody (18G102B2E11) [DyLight 405]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clone
18G102B2E11
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

mtTFA Antibody (18G102B2E11) [DyLight 405] Summary

Immunogen
Human mtTFA [Swiss-Prot# Q00059]
Localization
Mitochondrion.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TFAM
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This mtTFA (18G102B2E11) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot, where a band can be seen around 20 - 25 kDa.

Reactivity Notes

Human and rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for mtTFA Antibody (18G102B2E11) [DyLight 405]

  • mitochondrial transcription factor A
  • MtTF1
  • mtTFA
  • TCF-6
  • TCF6L1
  • TCF6L2Mitochondrial transcription factor 1
  • TCF6TCF6L3
  • Transcription factor 6
  • Transcription factor 6-like 2 (mitochondrial transcription factor)
  • Transcription factor 6-like 2
  • transcription factor A, mitochondrial

Background

mtTFA (transcription factor A, mitochondrial) is an essential protein that binds mitochondrial DNA (mtDNA) with or without sequence specificity to control mitochondrial transcription initiation and mtDNA copy number. mtTFA exists as monomer localized in mitochondrion matrix / nucleoid where it binds DNA and interacts with TFB1M/TFB2M. mtTFA associate with mitochondrial light strand promoter for controlling transcription and is essential for correct/efficient mtRNA polymerase promoter recognition. mtTFA is capable of unwinding DNA and bending mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes, and mtTFA is essential for controlling mtDNA levels as well as its organization/compaction. mtDNA is a multicopy, circular genome that is unquestionably required for respiratory function and interference with mitochondrial genome sequence fidelity, transcription, or translation can cause ATP insufficiency and several pathologies including progressive external ophthalmoplegia, amyotrophic lateral sclerosis (ALS), Alpers' disease, Parkinson's disease, Alzheimer's disease, aging, cardiovascular disease, diabetes and cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for mtTFA Antibody (NBP1-71648V) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-71648B
DyLight 350 Labeled NBP1-71648UV
DyLight 488 Labeled NBP1-71648G
DyLight 550 Labeled NBP1-71648R
DyLight 650 Labeled NBP1-71648C
DyLight 680 Labeled NBP1-71648FR
DyLight 755 Labeled NBP1-71648IR
FITC Labeled NBP1-71648F
HRP Labeled NBP1-71648H

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Bioinformatics Tool for mtTFA Antibody (NBP1-71648V)

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Contact Information

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Calculators

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Bioinformatics

Gene Symbol TFAM