mtTFA Antibody (18G102B2E11) [DyLight 650]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF, IHC, KD, KO
• Clone: 18G102B2E11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

mtTFA Antibody (18G102B2E11) [DyLight 650] Summary

• Immunogen: Human mtTFA [Swiss-Prot# Q00059]
• Localization: Mitochondrion.
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: TFAM
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Knockout Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28053692)

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for mtTFA Antibody (18G102B2E11) [DyLight 650]

• mitochondrial transcription factor A
• MtTF1
• mtTFA
• TCF-6
• TCF6L1
• TCF6L2Mitochondrial transcription factor 1
• TCF6TCF6L3
• Transcription factor 6
• Transcription factor 6-like 2 (mitochondrial transcription factor)
• Transcription factor 6-like 2
• transcription factor A, mitochondrial

Background

Mitochondrial transcription factor A (mtTFA) is one of the most important transcription factors related to mitochondrial genes. In turn, mtTFA regulates several pathways for metabolism and energy storage in cells. In several metabolic diseases, including insulin-resistance related diabetes, the activity of mtTFA is directly linked to interactions with oxidative stress and fat cell differentiation. In cancers, mtTFA is important in supporting the energy requirements of the fast-growing cells. When dysfunctions in mitochondrial activity occur, mtTFA and its relationship to other proteins is often to blame; mtTFA is known to interact with TNF-alpha, PPAR, UCP4, POLRMT and others. Increased expression of mtTFA might be a good biomarker for Arsenic-induced Bowen's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TFAM