MS4A3 Antibody (489433) [Fluorescein]

• Applications: Flow
• Clone: 489433
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Fluorescein

MS4A3 Antibody (489433) [Fluorescein] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human MS4A3
  Accession # NP_006129
• Specificity: Detects human MS4A3 in direct ELISAs.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: MS4A3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

MS4A3, also known as HTm4, is an membrane protein that is a member of the MS4A family of four-transmembrane proteins that also includes CD20 and Fc epsilon RI beta .  MS4A3 is a cell cycle regulator expressed in the perinuclear area of human basophils, eosinophils, early embryonic neural progenitors, splenic red pulp macrophages, monocytes and bile duct plus pancreatic duct epithelium. The C-terminal region of MS4A3 interacts with cdc-associated phosphatase (KAP), enhancing its activity on cyclin-dependent kinase 2 (cdk2) and facilitating G(0)/G(1) arrest. The combined non-membrane segments of the 214 amino acid (aa), 22-25 kDa human MS4A3 show 53% and 52% aa identity with corresponding regions of mouse and rat MS4A3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MS4A3