MS4A3 Antibody (489433) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 489433
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

MS4A3 Antibody (489433) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human MS4A3 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MS4A3 Antibody (489433) [Alexa Fluor™ Plus 488]

• CD20 antigen homolog
• CD20 antigen-like protein
• CD20L
• CD20LIgE receptor beta subunit
• hematopoietic cell 4 transmembrane protein
• Hematopoietic-specific transmembrane protein 4
• HTM4
• HTM4IgE receptor beta chain
• membrane-spanning 4-domains subfamily A member 3
• membrane-spanning 4-domains, subfamily A, member 3 (hematopoieticcell-specific)
• MS4A3

Background

MS4A3, also known as HTm4, is an intracytoplasmic membrane protein that is a member of the MS4A family of four-transmembrane proteins that also includes CD20 and Fc epsilon RI beta .  It is a cell cycle regulator expressed in the perinuclear area of human hematopoietic cells. The C-terminal region of MS4A3 interacts with cdc-associated phosphatase (KAP), enhancing its activity on cyclin-dependent kinase 2 (cdk2) and facilitating G(0)/G(1) arrest. The combined non-membrane segments of the 214 amino acid (aa), 25 kDa human MS4A3 show 53% and 52% aa identity with corresponding regions of mouse and rat MS4A3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.