Reactivity | HuSpecies Glossary |
Applications | WB, Flow, IHC, IHC-Fr |
Clone | M6II-7 |
Clonality | Monoclonal |
Host | Rat |
Conjugate | Unconjugated |
Immunogen | The antibody reacts with the MRP6 antigen. |
Specificity | M6II-7 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-7 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-7 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products. |
Isotype | IgG2 Alpha |
Clonality | Monoclonal |
Host | Rat |
Gene | ABCC6 |
Purity | Tissue culture supernatant |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | M6II-7 can be used to detect human MRP6 in cells and tissues. Immunocytochemistry: use 1:20-50 dilution on acetone fixed cytospin preparations. For immunohistochemistry: M6II-7 (use 1:20-50) on acetone fixed frozen sections can be followed by incubation w |
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Publications |
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Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer | PBS, 1% BSA |
Preservative | 0.1% Sodium Azide |
Purity | Tissue culture supernatant |
Publication using NBP1-42342 | Applications | Species |
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Roggenbeck BA, Carew MW, Charrois GJ et al. Characterization of Arsenic Hepatobiliary Transport Using Sandwich Cultured Human Hepatocytes. Toxicol. Sci. 2015 Mar 09 [PMID: 25752797] (WB, Human) | WB | Human |
Secondary Antibodies |
Isotype Controls |
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Gene Symbol | ABCC6 |