Mouse/Rat IL-22 Quantikine ELISA Kit

• Reactivity: Mu, Rt
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat IL-22 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse/Rat IL-22 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat IL-22 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse IL-22 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mou...se or rat IL-22 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse and rat IL-22.
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• Specificity: Natural and recombinant mouse and rat IL-22
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il22

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat IL-22 Quantikine ELISA Kit

• Cytokine Zcyto18
• IL-10-related T-cell-derived inducible factor
• IL22
• IL-22
• IL-D110
• IL-TIF
• ILTIFIL-10-related T-cell-derived-inducible factor
• IL-TIFMGC79382
• interleukin 22
• interleukin-22
• MGC79384
• TIFa
• TIFIL-23
• zcyto18

Background

IL-22 (Interleukin-22) is a cytokine that induces the production of reactive oxygen species, IL-6, IL-10, and TNF-alpha as well as neutrophil infiltration during inflammation. It also supports the integrity of epithelial barriers and induces epithelial cell proliferation during wound healing. IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. IL-10 R beta is a shared component of the receptor complexes for IL-10, IL-26, IL-28, and IL-29. IL-22 additionally binds to IL-22BP which blocks the interaction of IL-22 with IL-22 R.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-22 (M2200)(40)

Publications using M2200

• Chen, H;Sun, L;Feng, L;Han, X;Zhang, Y;Zhai, W;Zhang, Z;Mulholland, M;Zhang, W;Yin, Y; Intermittent fasting promotes ILC3s secreting IL-22 contributing to the beigeing of white adipose tissue bioRxiv : the preprint server for biology 2023-08-30 [PMID: 37693430] (Mouse)
• A Saga, M Koseki, K Kanno, J Chang, T Higo, D Okuzaki, T Okada, H Inui, M Asaji, K Tanaka, T Omatsu, S Nishihara, Y Zhu, K Ito, H Hattori, I Ichi, Y Kamada, M Ono, T Saibara, T Ohama, S Hikoso, M Nishida, S Yamashita, Y Sakata A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice International Journal of Molecular Sciences, 2022-12-13;23(24):. 2022-12-13 [PMID: 36555497] (Mouse)
• J Xiong, Y Zhao, Y Lin, L Chen, Q Weng, C Shi, X Liu, Y Geng, L Liu, J Wang, M Zhang Identification and characterization of innate lymphoid cells generated from pluripotent stem cells Cell Reports, 2022-11-01;41(5):111569. 2022-11-01 [PMID: 36323259] (Mouse)
• S Katiraei, JA van Diepen, LP Tavares, LR Hoving, A Pronk, I Verschuere, PCN Rensen, JJ Zwaginga, S Kostidis, M Giera, M Teixera, KW van Dijk, MG Netea, JFP Berbée, V van Harmel Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes Scientific Reports, 2022-04-27;12(1):6883. 2022-04-27 [PMID: 35477719] (Mouse)
• Y Feng, X Yang, J Huang, M Shen, L Wang, X Chen, Y Yuan, C Dong, X Ma, F Yuan Pharmacological Inhibition of Glutaminase 1 Attenuates Alkali-Induced Corneal Neovascularization by Modulating Macrophages Oxidative Medicine and Cellular Longevity, 2022-03-19;2022(0):1106313. 2022-03-19 [PMID: 35345831] (Mouse)
• S Taghavi, O Jackson-We, S Abdullah, A Wanek, R Drury, J Packer, A Cotton-Bet, J Duchesne, D Pociask, J Kolls Interleukin-22 mitigates acute respiratory distress syndrome (ARDS) PLoS ONE, 2021-10-01;16(10):e0254985. 2021-10-01 [PMID: 34597299] (Mouse)
• KJ Warren, JA Poole, JM Sweeter, JM DeVasure, JD Dickinson, RS Peebles, TA Wyatt Neutralization of IL-33 modifies the type 2 and type 3 inflammatory signature of viral induced asthma exacerbation Respiratory Research, 2021-07-15;22(1):206. 2021-07-15 [PMID: 34266437] (Mouse)
• LT Wang, MH Lin, KY Liu, SS Chiou, SN Wang, CY Chai, LW Tseng, HC Chiou, HC Wang, KK Yokoyama, SH Hsu, SK Huang WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism Autophagy, 2021-04-14;0(0):1-16. 2021-04-14 [PMID: 33853474] (Mouse)
• JA Lindborg, NM Tran, DM Chenette, K DeLuca, Y Foli, R Kannan, Y Sekine, X Wang, M Wollan, IJ Kim, JR Sanes, SM Strittmatt Optic nerve regeneration screen identifies multiple genes restricting adult neural repair Cell Reports, 2021-03-02;34(9):108777. 2021-03-02 [PMID: 33657370] (Mouse)
• K Tajiri, K Imanaka-Yo, Y Tsujimura, K Matsuo, M Hiroe, K Aonuma, M Ieda, Y Yasutomi A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Gu�rin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-&alpha International Journal of Molecular Sciences, 2021-01-14;22(2):. 2021-01-14 [PMID: 33466825] (Mouse)
• K Kobayashi, Y Honme, T Sashihara Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 Induce the Expression of the REG3 Family in the Small Intestine of Mice via the Stimulation of Dendritic Cells and Type 3 Innate Lymphoid Cells Nutrients, 2019-12-07;11(12):. 2019-12-07 [PMID: 31817820] (Mouse)
• L Zhu, C Xu, X Huo, H Hao, Q Wan, H Chen, X Zhang, RM Breyer, Y Huang, X Cao, DP Liu, GA FitzGerald, M Wang The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury Nat Commun, 2019-04-23;10(1):1888. 2019-04-23 [PMID: 31015404] (Mouse)
• C Guida, SD Stephen, M Watson, N Dempster, P Larraufie, T Marjot, T Cargill, L Rickers, M Pavlides, J Tomlinson, JFL Cobbold, CM Zhao, D Chen, F Gribble, F Reimann, R Gillies, B Sgromo, P Rorsman, JD Ryan, RD Ramracheya PYY plays a key role in the resolution of diabetes following bariatric surgery in humans EBioMedicine, 2019-01-11;0(0):. 2019-01-11 [PMID: 30639417] (Mouse)
• S Carvalho, M Ferrini, L Herritt, A Holian, Z Jaffar, K Roberts Multi-Walled Carbon Nanotubes Augment Allergic Airway Eosinophilic Inflammation by Promoting Cysteinyl Leukotriene Production Front Pharmacol, 2018-06-05;9(0):585. 2018-06-05 [PMID: 29922162] (Mouse)
• YT Lee, CT Wu, HL Sun, JL Ko, KH Lue Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine J Microbiol Immunol Infect, 2017-06-29;0(0):. 2017-06-29 [PMID: 28709839] (Mouse)
• SH Kim, BH Cho, H Kiyono, YS Jang Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer's patches Sci Rep, 2017-06-21;7(1):3980. 2017-06-21 [PMID: 28638068] (Mouse)
• G Aguilo-Sea, Y Xie, J Sheehan, LL Kusner, HJ Kaminski Ablation of IL-17 expression moderates experimental autoimmune myasthenia gravis disease severity Cytokine, 2017-06-06;96(0):279-285. 2017-06-06 [PMID: 28599246] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• WP Zheng, BY Zhang, ZY Shen, ML Yin, Y Cao, HL Song Biological effects of bone marrow mesenchymal stem cells on hepatitis B virus in�vitro Mol Med Rep, 2017-03-15;15(5):2551-2559. 2017-03-15 [PMID: 28447750] (Rat)
• Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol, 2015-02-02;16(3):286-95. 2015-02-02 [PMID: 25642823] (Mouse)
• Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis. J Immunol, 2014-07-21;193(5):2330-9. 2014-07-21 [PMID: 25049356] (Mouse)
• Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 2014-06-23;82(9):3723-39. 2014-06-23 [PMID: 24958709] (Mouse)
• Qin S, Wen J, Bai X, Chen T, Zheng R, Zhou G, Ma J, Feng J, Zhong B, Li Y Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis. Mol Med Rep, 2014-04-09;9(6):2097-104. 2014-04-09 [PMID: 24718773] (Mouse)
• Yano , Junko, Kolls , Jay K, Happel , Kyle I, Wormley , Floyd, Wozniak , Karen L, Fidel , Paul L J The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway. PLoS ONE, 2012-09-25;7(9):e46311. 2012-09-25 [PMID: 23050010] (Mouse)
• Wang , Penghua, Bai , Fengwei, Zenewicz , Lauren A, Dai , Jianfeng, Gate , David, Cheng , Gong, Yang , Long, Qian , Feng, Yuan , Xiaoling, Montgomery , Ruth R, Flavell , Richard, Town , Terrence, Fikrig , Erol IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS ONE, 2012-08-28;7(8):e44153. 2012-08-28 [PMID: 22952908] (Mouse)
• Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi. PLoS Pathog., 2012-07-12;8(7):e1002799. 2012-07-12 [PMID: 22807679] (Mouse)
• Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect. Immun., 2011-10-28;80(1):410-7. 2011-10-28 [PMID: 22038916] (Mouse)
• Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J. Exp. Med., 2011-03-07;208(3):491-503. 2011-03-07 [PMID: 21383056] (Mouse)
• Lindroos J, Svensson L, Norsgaard H IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6. J. Invest. Dermatol., 2011-02-03;131(5):1110-8. 2011-02-03 [PMID: 21289639] (Mouse)
• Kudva A, Scheller EV, Robinson KM Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J. Immunol., 2010-12-22;186(3):1666-74. 2010-12-22 [PMID: 21178015] (Mouse)
• Savan R, McFarland AP, Reynolds DA A novel role for IL-22R1 as a driver of inflammation. Blood, 2010-10-22;117(2):575-84. 2010-10-22 [PMID: 20971950] (Mouse)
• Kagami S, Rizzo HL, Kurtz SE IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J. Immunol., 2010-10-04;185(9):5453-62. 2010-10-04 [PMID: 20921529] (Mouse)
• Ziesche E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Muhl H Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin. Exp. Immunol., 2009-09-01;157(3):370-6. 2009-09-01 [PMID: 19664145] (Mouse)
• Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells. Cell. Immunol., 2009-05-27;258(2):147-51. 2009-05-27 [PMID: 19477436] (Mouse)
• Wahl C, Wegenka UM, Leithauser F, Schirmbeck R, Reimann J IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus entry mediator deficiency. J. Immunol., 2009-04-15;182(8):4521-8. 2009-04-15 [PMID: 19342625] (Mouse)
• Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int. Immunol., 2009-03-18;21(5):555-65. 2009-03-18 [PMID: 19297659] (Mouse)
• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008-09-15;181(6):4089-97. 2008-09-15 [PMID: 18768865] (Mouse)
• Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med., 2008-02-10;14(3):275-81. 2008-02-10 [PMID: 18264110] (Mouse)
• McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol., 2007-11-11;8(12):1390-7. 2007-11-11 [PMID: 17994024] (Mouse)
• Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol., 2007-08-05;8(9):958-66. 2007-08-05 [PMID: 17676043] (Mouse)

Bioinformatics

• Gene Symbol: Il22