Mouse Pentraxin 3/TSG-14 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Pentraxin 3/TSG-14 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ptx3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Pentraxin 3/TSG-14 DuoSet ELISA, 15 Plate

• alpha-induced protein 5
• pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor
• Pentaxin-related protein PTX3
• Pentraxin 3
• pentraxin 3, long
• pentraxin-3
• pentraxin-related gene, rapidly induced by IL-1 beta
• pentraxin-related protein PTX3
• PTX3
• TNF alpha-induced protein 5
• TNFAIP5
• TSG14
• TSG-14
• TSG-14pentaxin-related gene, rapidly induced by IL-1 beta
• Tumor necrosis factor alpha-induced protein 5
• tumor necrosis factor, alpha-induced protein 5
• Tumor necrosis factor-inducible gene 14 protein
• tumor necrosis factor-inducible protein TSG-14

Background

Pentraxin 3 (PTX3), also known as TNF-stimulated gene 14 (TSG-14), is a secreted glycoprotein belonging to the Pentraxin family of proteins. It is the prototypical long Pentraxin, exhibiting a C-terminal Pentraxin domain characteristic of the family, and a unique N-terminal domain. It is produced by several cell types including endothelial and mononuclear cells. PTX3 acts as a pattern recognition receptor with non-redundant roles in the innate immune response to several microbial agents including the fungal pathogen Aspergillus fumigatus. Overexpression leads to enhanced pro-inflammatory responses. PTX3 is induced in response to LPS and inflammatory cytokines including TNF-alpha and IL-1 beta.

Publications for Pentraxin 3/TSG-14 (DY2166)(8)

Publications using DY2166

• M Oggioni, D Mercurio, D Minuta, S Fumagalli, K Popiolek-B, M Sironi, A Ciechanows, S Ippati, D De Blasio, C Perego, J Mika, C Garlanda, MG De Simoni Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology Scientific Reports, 2021-05-05;11(1):9616. 2021-05-05 [PMID: 33953334] (Mouse)
• V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection PLoS Pathog., 2018-12-07;14(12):e1007469. 2018-12-07 [PMID: 30532257] (Mouse)
• D Gr?evi?, M Sironi, S Valentino, L Deban, H Cvija, A Inforzato, N Kova?i?, V Katavi?, T Kelava, I Kalajzi?, A Mantovani, B Bottazzi The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair Front Immunol, 2018-03-05;9(0):417. 2018-03-05 [PMID: 29556234] (Mouse)
• S Ainsworth, PM Ketter, JJ Yu, RC Grimm, HC May, AP Cap, JP Chambers, MN Guentzel, BP Arulananda Vaccination with a live attenuated Acinetobacter baumannii deficient in thioredoxin provides protection against systemic Acinetobacter infection Vaccine, 2017-05-15;0(0):. 2017-05-15 [PMID: 28522011] (Mouse)
• Foo , Suan-Sin, Chen , Weiqiang, Taylor , Adam, Sheng , Kuo-Chin, Yu , Xing, Teng , Terk-Shi, Reading , Patrick, Blanchard , Helen, Garlanda , Cecilia, Mantovani , Alberto, Ng , Lisa F P, Herrero , Lara J, Mahalingam , Suresh Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. PLoS Pathog, 2015-02-19;11(2):e1004649. 2015-02-19 [PMID: 25695775] (Mouse)
• Ketter P, Guentzel M, Schaffer B, Herzig M, Wu X, Montgomery R, Parida B, Fedyk C, Yu J, Jorgensen J, Chambers J, Cap A, Arulanandam B Severe Acinetobacter baumannii sepsis is associated with elevation of pentraxin 3. Infect Immun, 2014-07-07;82(9):3910-8. 2014-07-07 [PMID: 25001601] (Mouse)
• D'Angelo C, D'Angelo C, De Luca A, Zelante T, Bonifazi P, Moretti S, Giovannini G, Iannitti RG, Zagarella S, Bozza S, Campo S, Salvatori G, Romani L Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J. Immunol., 2009-09-04;183(7):4609-18. 2009-09-04 [PMID: 19734205] (Mouse)
• Souza DG, Amaral FA, Fagundes CT, Coelho FM, Arantes RM, Sousa LP, Matzuk MM, Garlanda C, Mantovani A, Dias AA, Teixeira MM The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice. Am. J. Pathol., 2009-03-12;174(4):1309-18. 2009-03-12 [PMID: 19286566] (Mouse)

FAQs for Pentraxin 3/TSG-14 (DY2166). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Ptx3