Mouse Osteoprotegerin/TNFRSF11B DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Osteoprotegerin/TNFRSF11B DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnfrsf11b

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Osteoprotegerin/TNFRSF11B DuoSet ELISA, 15 Plate

• OCIF
• OCIFMGC29565
• OPG
• OPGtumor necrosis factor receptor superfamily member 11B
• Osteoclastogenesis inhibitory factor
• Osteoprotegerin
• TNFRSF11B
• TR1
• tumor necrosis factor receptor superfamily, member 11b

Background

Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.

Publications for Osteoprotegerin/TNFRSF11B (DY459)(8)

Publications using DY459

• A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver Pharmaceutics, 2020-05-21;12(5):. 2020-05-21 [PMID: 32455750] (Mouse)
• ST Chen, L Kang, CZ Wang, PJ Huang, HT Huang, SY Lin, SH Chou, CC Lu, PC Shen, YS Lin, CH Chen (-)-Epigallocatechin-3-Gallate Decreases Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin Molecules, 2019-01-03;24(1):. 2019-01-03 [PMID: 30609798] (Mouse)
• James S O'Donnell Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria Thromb. Haemost., 2016-01-14;115(4):773-80. 2016-01-14 [PMID: 26766771] (Mouse)
• Chen W, Foo S, Taylor A, Lulla A, Merits A, Hueston L, Forwood M, Walsh N, Sims N, Herrero L, Mahalingam S Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. J Virol, 2014-10-22;89(1):581-93. 2014-10-22 [PMID: 25339772] (Mouse)
• Huang Q, Koessler R, Birkett R, Perlman H, Xing L, Pope R TLR2 deletion promotes arthritis through reduction of IL-10. J Leukoc Biol, 2013-02-27;93(5):751-9. 2013-02-27 [PMID: 23446149] (Mouse)
• Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans. J. Bone Miner. Res., 2011-08-01;26(8):1891-903. 2011-08-01 [PMID: 21509823] (Mouse)
• Reddi D, Bostanci N, Hashim A, Aduse-Opoku J, Curtis MA, Hughes FJ, Belibasakis GN Porphyromonas gingivalis regulates the RANKL-OPG system in bone marrow stromal cells. Microbes Infect., 2008-08-26;10(14):1459-68. 2008-08-26 [PMID: 18789397] (Mouse)
• O'Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, Watson M, Cornish J, Browett P, Grey A Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J. Bone Miner. Res., 2007-11-01;22(11):1679-89. 2007-11-01 [PMID: 17663639] (Mouse)

Bioinformatics

• Gene Symbol: Tnfrsf11b