Mouse Leptin R DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Leptin R DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Lepr

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Leptin R DuoSet ELISA, 15 Plate

• B219
• CD295 antigen
• CD295
• DB
• DKFZp686B1731
• huB219
• LEPR
• LEP-R
• Leptin R
• leptin receptor
• LeptinR
• OB R
• OB receptor
• OB-R
• OBRCD295

Background

Leptin receptor (OBR), also named B219, is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and the LIF receptor. Multiple isoforms of human and mouse OBR, including a long form (OBRL) with a large cytoplasmic domain capable of signal-transduction, and several receptor isoforms with short cytoplasmic domains (OBRS) lacking signal-transducing capabilities, have been identified.

Publications for Leptin R (DY497)(7)

Publications using DY497

• R Yamada, S Odamaki, M Araki, T Watanabe, K Matsuo, K Uchida, T Kato, Y Ozaki-Masu, A Takenaka Dietary protein restriction increases hepatic leptin receptor mRNA and plasma soluble leptin receptor in male rodents PLoS ONE, 2019-07-15;14(7):e0219603. 2019-07-15 [PMID: 31306448] (Rat, Mouse)
• S Pereira, SM O'Dwyer, TD Webber, RK Baker, V So, CE Ellis, JS Yoon, M Mojibian, MM Glavas, S Karunakara, SM Clee, SD Covey, TJ Kieffer Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues Sci Rep, 2019-03-01;9(1):3307. 2019-03-01 [PMID: 30824713] (Mouse)
• YH Lee, HC Hsu, PC Kao, YJ Shiao, SH Yeh, FS Shie, SM Hsu, CW Yeh, HK Liu, SB Yang, HJ Tsay Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation Int J Mol Sci, 2018-08-08;19(8):. 2018-08-08 [PMID: 30096853] (Mouse)
• Liu , Xianglan, McMurphy , Travis, Xiao , Run, Slater , Andrew, Huang , Wei, Cao , Lei Hypothalamic gene transfer of BDNF inhibits breast cancer progression and metastasis in middle age obese mice. Mol Ther, 2014-03-18;22(7):1275-84. 2014-03-18 [PMID: 24637454] (Mouse)
• Teijaro JR, Walsh KB, Cahalan S, Fremgen DM, Roberts E, Scott F, Martinborough E, Peach R, Oldstone MB, Rosen H Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell, 2011-09-16;146(6):980-91. 2011-09-16 [PMID: 21925319] (Mouse)
• Childs GV, Akhter N, Haney A The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity. Endocrinology, 2010-11-17;152(1):69-81. 2010-11-17 [PMID: 21084451] (Mouse)
• Shapiro NI, Khankin EV, van Meurs M Leptin exacerbates sepsis-mediated morbidity and mortality. J. Immunol., 2010-06-02;185(1):517-24. 2010-06-02 [PMID: 20519646] (Mouse)

Bioinformatics

• Gene Symbol: Lepr