Leptin R Products

Description

Leptin receptor (OB-R) is a type I cytokine receptor family protein with significant amino acid sequence identity with gp130, G-CSF receptor, and LIF receptor. An OB-R transcript encodes a soluble form of the receptor. The transcript was reported to be expressed predominantly in regions of the hypothalamus previously thought to be important in body weight regulation. OB-R binds leptin with high affinity and is a potent leptin antagonist. Human OB-R encodes a 1 165 amino acid residue precursor protein with a 22 amino acid residue signal peptide, an 816 amino acid residue extracellular domain, a 21 amino acid residue transmembrane domain and a 303 amino acid residue cytoplasmic domain.

Bioinformatics

Entrez	16847 Mouse 24536 Rat 3953 Human
Uniprot	AAI60009.1 Human NM_002303 Human NP_001003679 Human NP_001003680 Human NP_002294 Human NP_002294.2 Human P41159 Human P48356 Mouse P48357 Human
Product By Gene ID	3953
Alternate Names	CD295 antigen DB DKFZp686B1731 huB219 HuB219 LEP-R leptin receptor OB receptor OB-R OBRCD295

Research Areas for Leptin R

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Signal Transduction