Mouse IL-4 Quantikine ELISA Kit, 2 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse IL-4 Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Mouse IL-4 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-4 levels in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse IL-4 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-4 accurately. Results obtained using natural mouse IL-4 showe...d dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-4.
  Show More
• Specificity: Natural and recombinant mouse IL-4
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il4

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-4 Quantikine ELISA Kit, 2 Plate

• B cell growth factor 1
• BCDF
• B-cell stimulatory factor 1
• BCGF1
• BCGF-1
• binetrakin
• BSF1
• BSF-1
• IL4
• IL-4
• IL-4B_cell stimulatory factor 1
• IL4E12
• interleukin 4
• interleukin-4
• Lymphocyte stimulatory factor 1
• MGC79402
• pitrakinra

Background

IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-4 (M4000B)(165)

Publications using M4000B

• Shin, SH;Ye, MK;Chae, MH;Geum, SY;Aboraia, AS;Abdel-Aal, AM;Qayed, WS;El-Wahab, HAAA;Abou-Ghadir, OF;Aboul-Fadl, T; Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model Biomedicines 2024-08-29 [PMID: 39335479] (Mouse)
• Maruyama, Y;Ohsawa, Y;Suzuki, T;Yamauchi, Y;Ohno, K;Inoue, H;Yamamoto, A;Hayashi, M;Okuhara, Y;Muramatsu, W;Namiki, K;Hagiwara, N;Miyauchi, M;Miyao, T;Ishikawa, T;Horie, K;Hayama, M;Akiyama, N;Hirokawa, T;Akiyama, T; Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist Nature communications 2024-07-19 [PMID: 39030171] (Mouse)
• Cao, Z;Wang, J;Liu, X;Liu, Y;Li, F;Liu, M;Chiu, S;Jin, X; Helminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way mBio 2024-05-10 [PMID: 38727220] (Mouse)
• Ouyang, P;Cai, Z;Peng, J;Lin, S;Chen, X;Chen, C;Feng, Z;Wang, L;Song, G;Zhang, Z; SELENOK-dependent CD36 palmitoylation regulates microglial functions and A? phagocytosis Redox biology 2024-02-01 [PMID: 38320455] (Mouse)
• Ni, J;Guo, T;Zhou, Y;Jiang, S;Zhang, L;Zhu, Z; STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury Journal of translational medicine 2023-09-04 [PMID: 37667317] (Mouse)
• Jin, J;Fan, YJ;Nguyen, TV;Yu, ZN;Song, CH;Lee, SY;Shin, HS;Chai, OH; Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-?B Signaling Pathway International journal of molecular sciences 2023-08-07 [PMID: 37569890] (Mouse)
• Lin, CH;Kuo, YH;Shih, CC; Antidiabetic and Immunoregulatory Activities of Extract of Phyllanthus emblica L. in NOD with Spontaneous and Cyclophosphamide-Accelerated Diabetic Mice International journal of molecular sciences 2023-06-08 [PMID: 37373070] (Mouse)
• Iwanami, N;Richter, AS;Sikora, K;Boehm, T; Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR ? chain of iNKT cells Nature communications 2023-06-20 [PMID: 37339974] (Mouse)
• Piao, X;Duan, J;Jiang, N;Liu, S;Hou, N;Chen, Q; Schistosoma japonicum Tyrosine Hydroxylase is promising targets for immunodiagnosis and immunoprotection of Schistosomiasis japonica PLoS neglected tropical diseases 2023-06-05 [PMID: 37276235] (Mouse)
• Alves, JM;Inyushin, M;Tsytsarev, V;Roldan-Kalil, JA;Miranda-Valentin, E;Maldonado-Martinez, G;Ramos-Feliciano, KM;Hunter-Mellado, R; Adjuvant effect of dendritic cells activator Imiquimod in genetic immunization with HIV-1 p55 Gag Journal of immunological techniques in infectious diseases 2023-01-10 [PMID: 37205236] (Mouse)
• A Kolbinger, TJ Schäufele, H Steigerwal, J Friedel, S Pierre, G Geisslinge, K Scholich Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation Embo Molecular Medicine, 2022-12-21;0(0):e16796. 2022-12-21 [PMID: 36541656] (Mouse)
• W Chang, H Lv, L Tan, Z Gao, P Liu, D Qin, W Zhang, Y Xu Downregulation of deubiquitinating enzyme USP25 promotes the development of allergic rhinitis by enhancing TSLP signaling in the nasal epithelium Molecular Medicine Reports, 2022-09-30;26(5):. 2022-09-30 [PMID: 36177892] (Mouse, Transgenic Mouse)
• JO Lim, YH Kim, IS Lee, WI Kim, SJ Lee, SW Pak, IS Shin, T Kim Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 Frontiers in Pharmacology, 2022-08-11;13(0):906916. 2022-08-11 [PMID: 36034804] (Mouse)
• Y Ni, GH Wu, JJ Cai, R Zhang, Y Zheng, JQ Liu, XH Yang, X Yang, Y Shen, JM Lai, XM Ye, SJ Mo Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation International journal of biological sciences, 2022-08-08;18(13):5168-5184. 2022-08-08 [PMID: 35982894] (Mouse)
• B Kassa, MH Lee, R Kumar, C Mickael, L Sanders, RM Tuder, M Mentink-Ka, BB Graham Experimental Schistosoma japonicum-induced pulmonary hypertension PloS Neglected Tropical Diseases, 2022-04-13;16(4):e0010343. 2022-04-13 [PMID: 35417453] (Mouse)
• JQ Liu, XR Geng, TY Hu, LH Mo, XQ Luo, SY Qiu, DB Liu, ZG Liu, JB Shao, ZQ Liu, PC Yang Glutaminolysis is required in maintaining immune regulatory functions in B cells Mucosal Immunology, 2022-01-10;0(0):. 2022-01-10 [PMID: 35013572] (Mouse)
• A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani, Y Norimatsu, M Fukayama, S Ebata, T Fukasawa, A Yoshizaki-, Y Asano, K Morikawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis Nature Communications, 2021-10-12;12(1):5947. 2021-10-12 [PMID: 34642338] (Mouse)
• Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su Eosinophil extracellular traps drive asthma progression through neuro-immune signals Nature Cell Biology, 2021-10-06;23(10):1060-1072. 2021-10-06 [PMID: 34616019] (Mouse)
• Y Song, X Li, F Liu, H Zhu, Y Shen Isoalantolactone alleviates ovalbumin?induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR?gamma/KLF4 signals Molecular Medicine Reports, 2021-08-09;24(4):. 2021-08-09 [PMID: 34368878] (Mouse)
• H Nunokawa, Y Murakami, T Ishii, T Narita, H Ishii, H Takizawa, N Yamashita Crucial role of stimulator of interferon genes-dependent signaling in house dust mite extract-induced IgE production Scientific Reports, 2021-06-23;11(1):13157. 2021-06-23 [PMID: 34162937] (Mouse)
• W Wei, W Chen, N He HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation Journal of Translational Medicine, 2021-06-12;19(1):258. 2021-06-12 [PMID: 34118928] (Mouse)
• LT Wang, MH Lin, KY Liu, SS Chiou, SN Wang, CY Chai, LW Tseng, HC Chiou, HC Wang, KK Yokoyama, SH Hsu, SK Huang WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism Autophagy, 2021-04-14;0(0):1-16. 2021-04-14 [PMID: 33853474] (Mouse)
• H Zhang, S Ge, B Ni, K He, P Zhu, X Wu, Y Shao Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages Autophagy, 2021-05-04;0(0):. 2021-05-04 [PMID: 33849389] (Mouse)
• Q Li, X Lan, X Han, F Durham, J Wan, A Weiland, RC Koehler, J Wang Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36 Brain, Behavior, and Immunity, 2021-02-13;94(0):437-457. 2021-02-13 [PMID: 33588074] (Mouse)
• SN Chang, DK Dey, ST Oh, WH Kong, KH Cho, EM Al-Olayan, BS Hwang, SC Kang, JG Park Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1&alpha-NF-&kappaB Crosstalk In Vitro and In Vivo International Journal of Molecular Sciences, 2020-12-04;21(23):. 2020-12-04 [PMID: 33291656] (Mouse)
• T Iwasaki, S Watarai Oral &lambda-carrageenan�intake�alleviates�skin symptoms in a hapten induced atopic dermatitis-like model J. Vet. Med. Sci., 2020-09-17;0(0):. 2020-09-17 [PMID: 32938835] (Mouse)
• J Chida, H Hara, K Uchiyama, E Takahashi, H Miyata, H Kosako, Y Tomioka, T Ito, H Horiuchi, H Matsuda, H Kido, S Sakaguchi Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice PLoS Pathog., 2020-08-26;16(8):e1008823. 2020-08-26 [PMID: 32845931] (Mouse)
• B Li, Z Yuan, P Jain, HC Hung, Y He, X Lin, P McMullen, S Jiang De novo design of functional zwitterionic biomimetic material for immunomodulation Sci Adv, 2020-05-29;6(22):eaba0754. 2020-05-29 [PMID: 32523997] (Mouse)
• HC Tsai, CF Hsu, CC Huang, SF Huang, TH Li, YY Yang, MW Lin, TY Lee, CW Liu, YH Huang, MC Hou, HC Lin Propranolol Suppresses the T-Helper Cell Depletion-Related Immune Dysfunction in Cirrhotic Mice Cells, 2020-03-03;9(3):. 2020-03-03 [PMID: 32138352] (Mouse)
• S Mojarab, D Shahbazzad, M Moghbeli, Y Eshraghi, KP Bagheri, R Rahimi, MA Savoji, M Mahdavi Immune responses to HIV-1 polytope vaccine candidate formulated in aqueous and alcoholic extracts of Propolis: Comparable immune responses to Alum and Freund adjuvants Microb. Pathog., 2019-12-16;140(0):103932. 2019-12-16 [PMID: 31857237] (Mouse)
• W Hu, L Ma, G Yang, X Zeng, J Liu, B Cheng, T Hu, H Zhao, Z Liu Der p2?A20 DNA vaccine attenuates allergic inflammation in mice with allergic rhinitis Mol Med Rep, 2019-10-21;0(0):. 2019-10-21 [PMID: 31638224] (Mouse)
• SS Welc, I Flores, M Wehling-He, J Ramos, Y Wang, C Bertoni, JG Tidball Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy Nat Commun, 2019-06-26;10(1):2788. 2019-06-26 [PMID: 31243277] (Mouse, Transgenic Mouse)
• M Doosti, M Nassiri, K Nasiri, M Tahmooresp, S Zibaee Effect of IL-2 co-expressed or co-inoculated with immuno-dominant epitopes from VP1 protein of FMD virus on immune responses in BALB/c mice Iran J Basic Med Sci, 2019-03-01;22(3):302-309. 2019-03-01 [PMID: 31156792] (Mouse)
• A Floudas, G Aviello, C Schwartz, IB Jeffery, PW O'Toole, PG Fallon Schistosoma mansoni worm infection regulates the intestinal microbiota and susceptibility to colitis Infect. Immun., 2019-07-23;0(0):. 2019-07-23 [PMID: 31138616] (Mouse)
• M Doosti, M Nassiri, K Nasiri, M Tahmooresp, S Zibaee Immunogenic evaluation of FMD virus immuno-dominant epitopes coupled with IL-2/FcIgG in BALB/c mice Microb. Pathog., 2019-04-17;132(0):30-37. 2019-04-17 [PMID: 31004723] (Mouse)
• CT Wu, FH Lin, YT Lee, MS Ku, KH Lue Effect of Lactobacillus rhamnosus GG immunopathologic changes in chronic mouse asthma model J Microbiol Immunol Infect, 2019-03-23;0(0):. 2019-03-23 [PMID: 30952512] (Mouse)
• BG Lania, J Morari, AR Almeida, MND Silva, G Vieira-Dam, KA Lins, CL César, LA Velloso, NB Maia, ML Cintra, PENF Velho Topical essential fatty acid oil on wounds: Local and systemic effects PLoS ONE, 2019-01-04;14(1):e0210059. 2019-01-04 [PMID: 30608959] (Mouse)
• A Mohebbi, MS Ebrahimzad, S Baghban Ra, M Saeidi, A Tabarraei, SR Mohebbi, S Shirian, A Gorji, A Ghaemi Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression Virus Res., 2018-12-29;261(0):72-80. 2018-12-29 [PMID: 30599161] (Mouse)
• I Sulaiman, K Tan, N Mohtarrudi, JC Woei Lim, J Stanslas Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction Pulm Pharmacol Ther, 2018-09-21;0(0):. 2018-09-21 [PMID: 30244166] (Mouse)
• MH Yi, HP Kim, KY Jeong, JY Kim, IY Lee, TS Yong Effects of the Th2-dominant milieu on allergic responses in Der f 1-activated mouse basophils and mast cells Sci Rep, 2018-05-16;8(1):7706. 2018-05-16 [PMID: 29769546] (Mouse)
• H Wu, X Xu, J Li, J Gong, M Li TIM?4 blockade of KCs combined with exogenous TGF?β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts Int. J. Mol. Med., 2018-03-30;0(0):. 2018-03-30 [PMID: 29620252] (Mouse)
• HM Song, X Li, YY Liu, WP Lu, ZH Cui, L Zhou, D Yao, HM Zhang Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS Int. J. Mol. Med., 2018-03-27;0(0):. 2018-03-27 [PMID: 29620148] (Mouse)
• ZW Dong, YF Yuan Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury Int. J. Mol. Med., 2018-03-09;41(6):3353-3365. 2018-03-09 [PMID: 29532887] (Mouse)
• M Ramírez, S Santos, O Martínez, R Rodríguez, E Miranda, WD Ramos-Pere, M Otero Characterization of the immune response elicited by the vaccinia virus L3 protein delivered as naked DNA Vaccine, 2018-03-07;36(15):2049-2055. 2018-03-07 [PMID: 29525282] (Mouse)
• R Zhang, X Liu, Z Xiong, Q Huang, X Yang, H Yan, J Ma, Q Feng, Z Shen The immunomodulatory effects of Zn-incorporated micro/nanostructured coating in inducing osteogenesis Artif Cells Nanomed Biotechnol, 2018-03-08;0(0):1-8. 2018-03-08 [PMID: 29517404] (Mouse)
• H Zhang, H Li, A Shaikh, Y Caudle, B Yao, D Yin Inhibition of MicroRNA-23b Attenuates Immunosuppression in Late Sepsis through NIK, TRAF1 and XIAP J. Infect. Dis., 2018-06-20;0(0):. 2018-06-20 [PMID: 29506272] (Mouse)
• Q Lei, J Bi, H Chen, F Tian, X Gao, N Li, X Wang Glucagon-like peptide-2 improves intestinal immune function and diminishes bacterial translocation in a mouse model of parenteral nutrition Nutr Res, 2017-10-10;49(0):56-66. 2017-10-10 [PMID: 29420993] (ELISA Capture, Mouse)
• X Zhang, F Yang, J Zou, W Wu, H Jing, Q Gou, H Li, J Gu, Q Zou, J Zhang Immunization with Pseudomonas aeruginosa outer membrane vesicles stimulates protective immunity in mice Vaccine, 2018-02-14;36(8):1047-1054. 2018-02-14 [PMID: 29406241] (ELISA Capture, Mouse)
• VHS Kumar, H Wang, L Nielsen Adaptive immune responses are altered in adult mice following neonatal hyperoxia Physiol Rep, 2018-01-01;6(2):. 2018-01-01 [PMID: 29368801] (Mouse)
• AH Kim, JJ Chung, S Akilesh, A Koziell, S Jain, JB Hodgin, MJ Miller, TS Stappenbec, JH Miner, AS Shaw B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement JCI Insight, 2017-11-02;2(21):. 2017-11-02 [PMID: 29093269] (Mouse)
• T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768723] (Mouse)
• A Tang, C Li, Z Chen, T Li Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T�cells and T-bet/GATA-3 expression in NOD mice Mol Med Rep, 2017-07-28;0(0):. 2017-07-28 [PMID: 28765956] (Mouse)
• YT Lee, CT Wu, HL Sun, JL Ko, KH Lue Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine J Microbiol Immunol Infect, 2017-06-29;0(0):. 2017-06-29 [PMID: 28709839] (Mouse)
• BH Lee, HK Kim, M Jang, HJ Kim, SH Choi, SH Hwang, HC Kim, H Rhim, IH Cho, SY Nah Effects of Gintonin-Enriched Fraction in an Atopic Dermatitis Animal Model: Involvement of Autotaxin Regulation Biol. Pharm. Bull., 2017-01-01;40(7):1063-1070. 2017-01-01 [PMID: 28674249] (Mouse)
• F Yang, J Gu, L Yang, C Gao, H Jing, Y Wang, H Zeng, Q Zou, F Lv, J Zhang Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models Sci Rep, 2017-06-21;7(1):3957. 2017-06-21 [PMID: 28638106] (Mouse)
• SC Wagner, TE Ichim, V Bogin, WP Min, F Silva, AN Patel, S Kesari Induction and characterization of anti-tumor endothelium immunity elicited by ValloVax therapeutic cancer vaccine Oncotarget, 2017-04-25;8(17):28595-28613. 2017-04-25 [PMID: 28404894] (Mouse)
• U Fujii, N Miyahara, A Taniguchi, N Oda, D Morichika, E Murakami, H Nakayama, K Waseda, M Kataoka, H Kakuta, M Tanimoto, A Kanehiro Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma Respir. Res, 2017-01-23;18(1):23. 2017-01-23 [PMID: 28114934] (Mouse)
• NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis Sci Rep, 2016-12-14;6(0):39075. 2016-12-14 [PMID: 27966619] (Mouse)
• Ji-Hua Chen Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration Biomaterials, 2016-10-31;113(0):203-216. 2016-10-31 [PMID: 27821306] (Mouse)
• Kerbrat S, Vingert B, Junier M, Castellano F, Renault-Mihara F, Dos Reis Tavares S, Surenaud M, Noizat-Pirenne F, Boczkowski J, Guellaen G, Chneiweiss H, Le Gouvello S Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo. PLoS ONE, 2015-08-28;10(8):e0136885. 2015-08-28 [PMID: 26317969] (Mouse)
• Talib W, Saleh S Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice. PLoS ONE, 2015-04-28;10(4):e0124384. 2015-04-28 [PMID: 25919398] (Mouse)
• Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice. J Neuroinflammation, 2015-03-04;12(0):41. 2015-03-04 [PMID: 25885682] (Mouse)
• Martinez O, Miranda E, Ramirez M, Santos S, Rivera C, Vazquez L, Sanchez T, Tremblay R, Rios-Olivares E, Otero M Immunomodulator-based enhancement of anti smallpox immune responses. PLoS ONE, 2015-04-13;10(4):e0123113. 2015-04-13 [PMID: 25875833] (Mouse)
• Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10. PLoS ONE, 2015-03-31;10(3):e0123210. 2015-03-31 [PMID: 25826377] (Mouse)
• Mishra , Amarjit, Brown , Alexandr, Yao , Xianglan, Yang , Shutong, Park , Sung-Jun, Liu , Chengyu, Dagur , Pradeep, McCoy , J Philip, Keeran , Karen J, Nugent , Gayle Z, Jeffries , Kenneth, Qu , Xuan, Yu , Zu-Xi, Levine , Stewart, Chung , Jay H Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. Nat Commun, 2015-02-18;6(0):6224. 2015-02-18 [PMID: 25692509] (Mouse)
• Besnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw T, Couper K, Ryffel B, Liew F IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathog, 2015-02-06;11(2):e1004607. 2015-02-06 [PMID: 25659095] (Mouse)
• Li H, Hu D, Fan H, Zhang Y, LeSage G, Caudle Y, Stuart C, Liu Z, Yin D beta-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10. J Biol Chem, 2014-07-10;289(33):23075-85. 2014-07-10 [PMID: 25012660] (Mouse)
• Li , Manyu, Wetzel-Strong , Sarah E, Hua , Xiaoyang, Tilley , Stephen, Oswald , Erin, Krummel , Matthew, Caron , Kathleen Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. PLoS ONE, 2014-07-10;9(7):e102356. 2014-07-10 [PMID: 25010197] (Mouse)
• Dengler E, Alberti L, Bowman B, Kerwin A, Wilkerson J, Moezzi D, Limanovich E, Wallace J, Milligan E Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain. J Neuroinflammation, 2014-05-21;11(0):92. 2014-05-21 [PMID: 24884664] (Mouse)
• Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol, 2014-03-24;192(9):4032-42. 2014-03-24 [PMID: 24663677] (Mouse)
• Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J Immunol, 2014-03-21;192(8):3569-81. 2014-03-21 [PMID: 24659691] (Mouse)
• Subramanian M, Kini R, Madasu M, Ohta A, Nowak M, Exley M, Sitkovsky M, Ohta A Extracellular adenosine controls NKT-cell-dependent hepatitis induction. Eur J Immunol, 2014-02-19;44(4):1119-29. 2014-02-19 [PMID: 24448964] (Mouse)
• Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response. FASEB J, 2014-01-03;28(4):1756-68. 2014-01-03 [PMID: 24391131] (Mouse)
• Ji W, Ma Y, Zhou X, Zhang Y, Lu R, Guo Z, Sun H, Hu D, Yang G, Li Y, Wei L Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments. PLoS ONE, 2013-11-19;8(11):e81090. 2013-11-19 [PMID: 24260540] (Mouse)
• Li G, Fox J, Liu Z, Liu J, Gao G, Jin Y, Gao H, Wu M Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models. J Immunol, 2013-10-14;191(11):5359-70. 2013-10-14 [PMID: 24127553] (Mouse)
• Johnson T, Rangel D, Graham B, Brough D, Gall J Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation. Mol Ther, 2013-06-10;22(1):196-205. 2013-06-10 [PMID: 23752342] (Mouse)
• Kim , Janice J, Bridle , Byram W, Ghia , Jean-Eri, Wang , Huaqing, Syed , Shahzad, Manocha , Marcus M, Rengasamy , Palanive, Shajib , Mohammad, Wan , Yonghong, Hedlund , Peter B, Khan , Waliul I Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J Immunol, 2013-04-03;190(9):4795-804. 2013-04-03 [PMID: 23554310] (Mouse)
• Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan. J Immunol, 2013-03-20;190(8):4116-28. 2013-03-20 [PMID: 23514738] (Mouse)
• Mizutani N, Nabe T, Yoshino S Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice. Immunology, 2013-06-01;139(2):205-18. 2013-06-01 [PMID: 23323935] (Mouse)
• Denis O, Vincent M, Havaux X, De Prins S, Treutens G, Huygen K Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata. Eur J Immunol, 2013-02-20;43(4):907-17. 2013-02-20 [PMID: 23319328] (Mouse)
• Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi. PLoS Pathog., 2012-07-12;8(7):e1002799. 2012-07-12 [PMID: 22807679] (Mouse)
• TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis. Eur. J. Immunol., 2012-08-01;42(8):2087-99. 2012-08-01 [PMID: 22622993] (Mouse)
• Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011-12-23;188(3):1503-13. 2011-12-23 [PMID: 22198948] (Mouse)
• Provoost S, Maes T, Joos GF, Tournoy KG Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent. J. Allergy Clin. Immunol., 2011-09-08;129(2):483-91. 2011-09-08 [PMID: 21906792] (Mouse)
• Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J. Immunol., 2011-06-29;187(3):1333-46. 2011-06-29 [PMID: 21715688] (Mouse)
• Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am. J. Pathol., 2011-05-10;179(1):302-14. 2011-05-10 [PMID: 21703412] (Mouse)
• Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models. Am. J. Pathol., 2011-05-18;179(1):230-9. 2011-05-18 [PMID: 21703405] (Mouse)
• Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol., 2011-05-25;41(6):1675-86. 2011-05-25 [PMID: 21469105] (Mouse)
• Diao J, Zhao J, Winter E Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6. J. Immunol., 2011-03-23;186(9):5058-67. 2011-03-23 [PMID: 21430223] (Mouse)
• Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma. Clin. Exp. Allergy, 2011-03-24;41(8):1133-42. 2011-03-24 [PMID: 21429049] (Mouse)
• Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI Serotonin activates dendritic cell function in the context of gut inflammation. Am. J. Pathol., 2011-02-01;178(2):662-71. 2011-02-01 [PMID: 21281798] (Mouse)
• Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference. Immunol. Lett., 2011-01-26;136(2):194-202. 2011-01-26 [PMID: 21277900] (Mouse)
• Wright PL, Yu J, Di YP Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. J. Exp. Med., 2010-10-25;207(12):2595-607. 2010-10-25 [PMID: 20975041] (Mouse)
• Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 2010-07-21;185(4):2044-50. 2010-07-21 [PMID: 20660352] (Mouse)
• Yoshizaki A, Yanaba K, Iwata Y Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol., 2010-07-12;185(4):2502-15. 2010-07-12 [PMID: 20624949] (Mouse)
• Niwa S, Urtz N, Baumruker T, Billich A, Bornancin F Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice. Lipids Health Dis, 2010-01-06;9(0):1. 2010-01-06 [PMID: 20053284] (Mouse)
• Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-09-25;298(1):L67-78. 2009-09-25 [PMID: 19783640] (Mouse)
• Mizutani N, Nabe T, Yoshino S Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J. Immunol., 2009-08-14;183(6):4039-46. 2009-08-14 [PMID: 19684087] (Mouse)
• Liu J, Ngai N, Stone GW, Yue FY, Ostrowski MA The adjuvancy of OX40 ligand (CD252) on an HIV-1 canarypox vaccine. Vaccine, 2009-06-30;27(37):5077-84. 2009-06-30 [PMID: 19573639] (Mouse)
• Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol., 2009-06-19;183(2):1291-300. 2009-06-19 [PMID: 19542374] (Mouse)
• Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm. Res., 2009-06-09;58(12):845-54. 2009-06-09 [PMID: 19506803] (Mouse)
• Izumo T, Kondo M, Nagai A Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis. Eur. Respir. J., 2009-05-21;34(6):1444-51. 2009-05-21 [PMID: 19460787] (Mouse)
• Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment. J. Immunol., 2009-06-01;182(11):6907-14. 2009-06-01 [PMID: 19454687] (Mouse)
• Bosnjak B, Ivetic Tkalcevic V, Duric K, Belamaric D, Cuzic S, Ferencic Z, Brajsa K, Glojnaric I, Antolovic R, Hrvacic B Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma. Inflamm. Res., 2009-05-08;58(11):773-81. 2009-05-08 [PMID: 19440656] (Mouse)
• Johnson TR, Rao S, Seder RA, Chen M, Graham BS TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity. Vaccine, 2009-04-03;27(23):3045-52. 2009-04-03 [PMID: 19428918] (Mouse)
• Chiba Y, Sato S, Misawa M Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice. Inflamm. Res., 2009-05-06;0(0):. 2009-05-06 [PMID: 19418204] (Mouse)
• Kim DY, Park JW, Jeoung D, Ro JY Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model. Eur. J. Pharmacol., 2009-04-05;612(1):98-105. 2009-04-05 [PMID: 19356734] (Mouse)
• Shinagawa K, Ploplis VA, Castellino FJ A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-03-13;296(5):L763-70. 2009-03-13 [PMID: 19286924] (Mouse)
• Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. J. Immunol., 2008-11-15;181(10):7157-65. 2008-11-15 [PMID: 18981137] (Mouse)
• Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, Kim GY Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem. Biophys. Res. Commun., 2008-08-13;375(2):275-9. 2008-08-13 [PMID: 18706396] (Mouse)
• Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem. Biophys. Res. Commun., 2008-07-24;374(3):507-11. 2008-07-24 [PMID: 18656449] (Mouse)
• Lee CM, Chang JH, Moon DO, Choi YH, Choi IW, Park YM, Kim GY Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma. Biochem. Biophys. Res. Commun., 2008-07-16;374(2):248-52. 2008-07-16 [PMID: 18638450] (Mouse)
• Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. J. Immunol., 2008-07-15;181(2):1491-8. 2008-07-15 [PMID: 18606704] (Mouse)
• Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur. J. Pharmacol., 2008-06-16;590(1):400-8. 2008-06-16 [PMID: 18598692] (Mouse)
• Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response. Vaccine, 2008-06-12;26(33):4237-43. 2008-06-12 [PMID: 18584925] (Mouse)
• Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes. J. Endocrinol., 2008-06-18;198(3):581-9. 2008-06-18 [PMID: 18562629] (Mouse)
• Liu J, Yu Q, Stone GW, Yue FY, Ngai N, Jones RB, Kornbluth RS, Ostrowski MA CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals. Vaccine, 2008-06-02;26(32):4062-72. 2008-06-02 [PMID: 18562053] (Mouse)
• Johnson TR, Rothenberg ME, Graham BS Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. J. Leukoc. Biol., 2008-06-02;84(3):748-59. 2008-06-02 [PMID: 18519743] (Mouse)
• Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl. Acad. Sci. U.S.A., 2008-05-14;105(20):7240-5. 2008-05-14 [PMID: 18480254] (Mouse)
• Besin G, Gaudreau S, Menard M, Guindi C, Dupuis G, Amrani A Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes, 2008-05-13;57(8):2107-17. 2008-05-13 [PMID: 18477807] (Mouse)
• Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. Eur. J. Immunol., 2008-05-01;38(5):1358-67. 2008-05-01 [PMID: 18425727] (Mouse)
• Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis. Am. J. Pathol., 2008-04-10;172(5):1209-21. 2008-04-10 [PMID: 18403600] (Mouse)
• Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med., 2008-03-03;205(3):699-710. 2008-03-03 [PMID: 18316417] (Mouse)
• Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum., 2008-03-01;58(3):754-63. 2008-03-01 [PMID: 18311788] (Mouse)
• Vanhoutte F, Paget C, Breuilh L, Fontaine J, Vendeville C, Goriely S, Ryffel B, Faveeuw C, Trottein F Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells. Immunol. Lett., 2007-12-17;116(1):86-94. 2007-12-17 [PMID: 18166232] (Mouse)
• Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. J. Immunol., 2008-01-01;180(1):522-9. 2008-01-01 [PMID: 18097054] (Mouse)
• Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood, 2007-09-20;111(1):219-28. 2007-09-20 [PMID: 17885078] (Mouse)
• Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation. J. Immunol., 2007-10-01;179(7):4415-23. 2007-10-01 [PMID: 17878337] (Mouse)
• Lee SI, Kwon HJ, Lee ES, Yang BC, Bang D, Lee S, Sohn S Using pCIN-mIL-4 DNA vector to express mRNA and protein and to improve herpes simplex virus-induced Behcet's disease symptoms in mice. Vaccine, 2007-08-20;25(41):7047-55. 2007-08-20 [PMID: 17822810] (Mouse)
• Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3638-47. 2007-09-15 [PMID: 17785799] (Mouse)
• Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol., 2007-05-31;82(3):488-96. 2007-05-31 [PMID: 17540734] (Mouse)
• Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling. Immunology, 2007-05-16;122(2):268-78. 2007-05-16 [PMID: 17506853] (Mouse)
• Daniel C, Sartory NA, Zahn N FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. Mol. Immunol., 2007-05-01;44(13):3305-16. 2007-05-01 [PMID: 17475330] (Mouse)
• Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci., 2007-02-03;80(20):1821-31. 2007-02-03 [PMID: 17400256] (Mouse)
• Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am. J. Pathol., 2007-04-01;170(4):1152-64. 2007-04-01 [PMID: 17392156] (Mouse)
• Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol. Ther., 2007-03-20;15(5):971-80. 2007-03-20 [PMID: 17375074] (Mouse)
• Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet., 2007-02-04;39(3):329-37. 2007-02-04 [PMID: 17277778] (Mouse)
• Van Hove CL, Maes T, Joos GF, Tournoy KG Prolonged inhaled allergen exposure can induce persistent tolerance. Am. J. Respir. Cell Mol. Biol., 2007-01-11;36(5):573-84. 2007-01-11 [PMID: 17218615] (Mouse)
• Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J. Allergy Clin. Immunol., 2006-10-23;119(1):123-31. 2006-10-23 [PMID: 17208593] (Mouse)
• Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J. Immunol., 2007-01-15;178(2):851-7. 2007-01-15 [PMID: 17202346] (Mouse)
• Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J. Immunol., 2007-01-01;178(1):480-8. 2007-01-01 [PMID: 17182587] (Mouse)
• Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS Lett., 2006-12-11;581(1):57-64. 2006-12-11 [PMID: 17174308] (Mouse)
• Furuta T, Yoshikawa Y Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis. Int. Immunol., 2006-10-11;18(12):1655-62. 2006-10-11 [PMID: 17035347] (Mouse)
• Wieland CW, Kerver ME, Florquin S, Nolte MA, Borst J, van Lier R, van Oers MH, van der Poll T CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome. Int. Immunol., 2006-09-11;18(11):1531-9. 2006-09-11 [PMID: 16966496] (Mouse)
• Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model. Biosci. Biotechnol. Biochem., 2006-08-01;70(8):2013-7. 2006-08-01 [PMID: 16926520] (Mouse)
• Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli. Eur. J. Immunol., 2006-08-01;36(8):2116-27. 2006-08-01 [PMID: 16856206] (Mouse)
• Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R Allergic airway inflammation inhibits pulmonary antibacterial host defense. J. Immunol., 2006-08-01;177(3):1833-7. 2006-08-01 [PMID: 16849494] (Mouse)
• Xu X, Wei H, Dong Z, Chen Y, Tian Z The differential effects of low dose and high dose concanavalin A on cytokine profile and their importance in liver injury. Inflamm. Res., 2006-04-01;55(4):144-52. 2006-04-01 [PMID: 16807695] (Mouse)
• Jia Y, Li H, Chen W, Li M, Lv M, Feng P, Hu H, Zhang L Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES. Gene Ther., 2006-05-18;13(18):1351-9. 2006-05-18 [PMID: 16708076] (Mouse)
• Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues. J. Immunol., 2006-02-15;176(4):2568-80. 2006-02-15 [PMID: 16456019] (Mouse)
• Hahn T, Alvarez I, Kobie JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int. J. Cancer, 2006-05-01;118(9):2220-31. 2006-05-01 [PMID: 16331615] (Mouse)
• Shibamori M, Ogino K, Kambayashi Y, Ishiyama H Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice. Life Sci., 2005-10-17;78(9):987-94. 2005-10-17 [PMID: 16229861] (Mouse)
• Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 2005-08-15;175(4):2589-97. 2005-08-15 [PMID: 16081833] (Mouse)
• Li GP, Liu ZG, Ran PX, Zhong NS DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Der p 2 allergen-induced allergic airway inflammation mice model. Chin. Med. J., 2005-04-05;118(7):534-40. 2005-04-05 [PMID: 15820083] (Mouse)
• Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest., 2005-02-01;115(2):459-67. 2005-02-01 [PMID: 15650773] (Human)
• Maeda K, Hirano T, Ichimiya I, Kurono Y, Suzuki M, Mogi G Cytokine expression in experimental chronic otitis media with effusion in mice. Laryngoscope, 2004-11-01;114(11):1967-72. 2004-11-01 [PMID: 15510024] (Mouse)
• Yu G, Luo H, Wu Y, Wu J EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J. Biol. Chem., 2004-10-22;279(53):55531-9. 2004-10-22 [PMID: 15502157] (Mouse)
• Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp. Immunol. Microbiol. Infect. Dis., 2004-11-01;27(6):393-411. 2004-11-01 [PMID: 15325513] (Mouse)
• Johnson TR, Varga SM, Braciale TJ, Graham BS Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV. J. Virol., 2004-08-01;78(16):8753-60. 2004-08-01 [PMID: 15280483] (Mouse)
• Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J. Immunol., 2004-06-15;172(12):7408-16. 2004-06-15 [PMID: 15187118] (Mouse)
• Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C Control of Leishmania major in the absence of Tyk2 kinase. Eur. J. Immunol., 2004-02-01;34(2):519-29. 2004-02-01 [PMID: 14768057] (Mouse)
• Harandi AM, Eriksson K, Holmgren J A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J. Virol., 2003-01-01;77(2):953-62. 2003-01-01 [PMID: 12502811] (Mouse)
• Huaux F, 107322, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-09-01;169(5):2653-61. 2002-09-01 [PMID: 12193738] (Mouse)
• Oka H, Emori Y, Sasaki H, Shiraishi Y, Yoshinaga K, Kurimoto T Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis. Microbiol. Immunol., 2002-01-01;46(5):343-51. 2002-01-01 [PMID: 12139394] (Mouse)
• Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes, 2002-05-01;51(5):1356-61. 2002-05-01 [PMID: 11978630] (Mouse)

Bioinformatics

• Gene Symbol: Il4