Mouse IL-33 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-33 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il33

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-33 DuoSet ELISA, 15 Plate

• C9orf26
• C9orf26chromosome 9 open reading frame 26 (NF-HEV)
• DKFZp586H0523
• DVS27
• DVS27-related protein
• IL1F11
• IL-1F11
• IL33
• IL-33
• interleukin 33
• Interleukin-1 family member 11
• interleukin-33
• NFHEV
• NF-HEV
• NF-HEVNFEHEV
• Nuclear factor from high endothelial venules
• RP11-575C20.2

Background

IL-33 (Interleukin-33) is released from physically damaged or necrotic cells. It triggers Th2-biased immune cell activation at sites of inflammation as well as regulatory T cell and M2 macrophage expansion. It additionally induces angiogenesis, promotes tumor cell migration and invasion, limits cardiac myocyte hypertrophy, and limits the development of atherosclerotic plaques. IL-33 signals through a receptor complex composed of ST2 and IL-1 RAcP. IL-1 RAcP also associates with IL-1 RI, IL-1 RII, IL-1 R6, and SCF R/c-kit. Soluble isoforms of ST2 and IL-1 RAcP function as decoy receptors that regulate IL-33 bioactivity.

Publications for IL-33 (DY3626)(58)

Publications using DY3626

• Cook, PC;Brown, SL;Houlder, EL;Furlong-Silva, J;Conn, DP;Colombo, SAP;Baker, S;Svedberg, FR;Howell, G;Bertuzzi, M;Boon, L;Konkel, JE;Thornton, CR;Allen, JE;MacDonald, AS; Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice Nature communications 2025-01-22 [PMID: 39843887] (Mouse)
• Schumacher, MA;Thai, MH;Hsieh, JJ;Gramajo, A;Liu, CY;Frey, MR; Wnt/?-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis Mucosal immunology 2024-11-24 [PMID: 39592069] (Mouse)
• Agner, K;McQuade, VL;Womble, J;Guttenberg, MA;Phatak, S;Ingram, JL; Withaferin A reduces pulmonary eosinophilia and IL-25 production in a mouse model of allergic airways disease bioRxiv : the preprint server for biology 2024-08-26 [PMID: 39253456] (Mouse)
• Hussain, S;Majumder, N;Mazumder, MHH;Lewis, SE;Olapeju, O;Velayutham, M;Amin, MS;Brundage, K;Kelley, EE;Vanoirbeek, J; Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype Redox biology 2024-10-01 [PMID: 39244793] (Mouse)
• Mattar, P;Reginato, A;Lavados, C;Das, D;Kalyani, M;Martinez-Lopez, N;Sharma, M;Skovbjerg, G;Skytte, JL;Roostalu, U;Subbarayan, R;Picarda, E;Zang, X;Zhang, J;Guha, C;Schwartz, G;Rajbhandari, P;Singh, R; Insulin and leptin oscillations license food-entrained browning and metabolic flexibility Cell reports 2024-06-19 [PMID: 38900636] (Mouse, Transgenic Mouse)
• Jiao, M;Wang, C;Tang, X;Dai, C;Zhang, N;Fan, A;Qian, Z;Liu, S;Zhang, F;Li, B;Xu, Y;Tan, Z;Gong, F;Lu, Y;Zheng, F; Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis Brain, behavior, and immunity 2024-04-24 [PMID: 38663774] (Mouse, Transgenic Mouse)
• Ajendra, J;Papotto, PH;Parkinson, JE;Dodd, RJ;Bombeiro, AL;Pearson, S;Chan, BHK;Ribot, JC;McSorley, HJ;Sutherland, TE;Allen, JE; The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration Mucosal immunology 2023-09-30 [PMID: 37783278] (Mouse, Transgenic Mouse)
• Hollifield, IE;Motyka, NI;Fernando, KA;Bitoun, JP; Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli Microorganisms 2023-08-21 [PMID: 37630681] (Mouse)
• Takimoto-Sato, M;Suzuki, M;Kimura, H;Ge, H;Matsumoto, M;Makita, H;Arai, S;Miyazaki, T;Nishimura, M;Konno, S; Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD Respiratory research 2023-08-17 [PMID: 37592330] (Mouse)
• Maggi, L;Camelo, GMA;Rocha, IC;Pereira Alves, W;Moreira, JMP;Almeida Pereira, T;Tafuri, WL;Rabelo, ÉML;Correa, A;Ecco, R;Negrão-Corrêa, DA; Role of the IL-33/ST2 Activation Pathway in the Development of the Hepatic Fibrosis Induced by Schistosoma mansoni Granulomas in Mice International journal of molecular sciences 2023-06-16 [PMID: 37373379] (Mouse)
• Jeon, YJ;Gil, CH;Won, J;Jo, A;Kim, HJ; Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis BMC microbiology 2023-05-26 [PMID: 37237381] (Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Mouse)
• W Chen, S Chen, C Yan, Y Zhang, R Zhang, M Chen, S Zhong, W Fan, S Zhu, D Zhang, X Lu, J Zhang, Y Huang, L Zhu, X Li, D Lv, Y Fu, H Iv, Z Ling, L Ma, H Jiang, G Long, J Zhu, D Wu, B Wu, B Sun Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion Nature Immunology, 2022-07-06;23(7):1021-1030. 2022-07-06 [PMID: 35794369] (Mouse)
• CR Morris, A Habibovic, CM Dustin, C Schiffers, MC Lin, JL Ather, YMW Janssen-He, ME Poynter, O Utermohlen, M Krönke, A van der Vl Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease Mucosal Immunology, 2022-06-02;0(0):. 2022-06-02 [PMID: 35654836] (Mouse)
• Lauren M. Buelow, Akihiko Hoji, Kiet Tat, Lindsay M. Schroeder-Carter, Daniela J. Carroll, Joan M. Cook-Mills Mechanisms for Alternaria alternata Function in the Skin During Induction of Peanut Allergy in Neonatal Mice With Skin Barrier Mutations Frontiers in Allergy 2021-09-06 [PMID: 35387035] (Mouse)
• CA Malinczak, CF Schuler, AJ Duran, AJ Rasky, MM Mire, G Núñez, NW Lukacs, W Fonseca NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development Viruses, 2021-04-16;13(4):. 2021-04-16 [PMID: 33923693] (Mouse)
• E Katz-Kiria, DF Steinberg, CE Kluender, OA Osorio, C Newsom-Ste, A Baronia, DE Byers, MJ Holtzman, D Katafiasz, KL Bailey, SL Brody, MJ Miller, J Alexander- Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease JCI Insight, 2021-02-22;0(0):. 2021-02-22 [PMID: 33507882] (Mouse)
• JPK Mukendi, R Nakamura, S Uematsu, S Hamano Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice Parasites & vectors, 2021-01-22;14(1):70. 2021-01-22 [PMID: 33482904] (Mouse)
• R Corrêa, I de Oliveir, HA Braz-de-Me, LP de Sant'An, R das Neves, G Pasquarell, PS Prado, GP Kobinger, CF Maurice, KG Magalhães Gut microbiota modulation induced by Zika virus infection in immunocompetent mice Scientific Reports, 2021-01-14;11(1):1421. 2021-01-14 [PMID: 33446825] (Mouse)
• O Dusek, A Fajstova, A Klimova, P Svozilkova, T Hrncir, M Kverka, S Coufal, J Slemin, H Tlaskalova, JV Forrester, J Heissigero Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917 Cells, 2020-12-25;10(1):. 2020-12-25 [PMID: 33375578] (Mouse)
• B Gutierrez, I Gallardo, L Ruiz, Y Alvarez, V Cachofeiro, A Margolles, M Hernandez, ML Nieto Oleanolic acid ameliorates intestinal alterations associated with EAE J Neuroinflammation, 2020-11-27;17(1):363. 2020-11-27 [PMID: 33246492] (Mouse)
• YJ Jeon, CH Gil, J Won, A Jo, HJ Kim Symbiotic microbiome Staphylococcus aureus from human nasal mucus modulates IL-33-mediated type 2 immune responses in allergic nasal mucosa BMC Microbiol, 2020-10-07;20(1):301. 2020-10-07 [PMID: 33028252] (Mouse)
• AJ Knights, EJ Vohralik, PJ Houweling, ES Stout, LJ Norton, SJ Alexopoulo, JJ Yik, H Mat Jusoh, EM Olzomer, KS Bell-Ander, KN North, KL Hoehn, M Crossley, KGR Quinlan Eosinophil function in adipose tissue is regulated by Kr�ppel-like factor 3 (KLF3) Nat Commun, 2020-06-10;11(1):2922. 2020-06-10 [PMID: 32523103] (Mouse)
• R Santos, PC Campos, M Rungue, V Rocha, D Santos, V Mendes, FV Marinho, F Martins, MF Ricci, DCD Reis, GD Cassali, JC Alves-Filh, AT Vieira, SC Oliveira The Role of ST2 Receptor in the Regulation of Brucella abortus Oral Infection Pathogens, 2020-04-28;9(5):. 2020-04-28 [PMID: 32353980] (Mouse)
• W Fonseca, CA Malinczak, CF Schuler, SKK Best, AJ Rasky, SB Morris, TX Cui, AP Popova, NW Lukacs Uric acid pathway activation during respiratory virus infection promotes Th2 immune response via innate cytokine production and ILC2 accumulation Mucosal Immunol, 2020-02-11;0(0):. 2020-02-11 [PMID: 32047272] (Mouse)
• AL Frisbee, MM Saleh, MK Young, JL Leslie, ME Simpson, MM Abhyankar, CA Cowardin, JZ Ma, P Pramoonjag, SD Turner, AP Liou, EL Buonomo, WA Petri IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection Nat Commun, 2019-06-20;10(1):2712. 2019-06-20 [PMID: 31221971] (Mouse)
• JD Burleson, D Siniard, VK Yadagiri, X Chen, MT Weirauch, BP Ruff, EB Brandt, GKK Hershey, H Ji TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells Sci Rep, 2019-05-14;9(1):7361. 2019-05-14 [PMID: 31089182] (Mouse)
• N Schaunaman, A Sanchez, KG Dimasuay, N Pavelka, M Numata, R Alam, RJ Martin, HW Chu Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation Infect. Immun., 2019-06-20;87(7):. 2019-06-20 [PMID: 31061143] (Mouse)
• EM Nakada, NR Bhakta, BR Korwin-Mih, A Kumar, N Chamberlai, SR Bruno, DG Chapman, SM Hoffman, N Daphtary, M Aliyeva, CG Irvin, AE Dixon, PG Woodruff, S Amin, ME Poynter, DH Desai, V Anathy Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers JCI Insight, 2019-05-02;4(9):. 2019-05-02 [PMID: 31045581] (Mouse)
• C Donovan, MR Starkey, RY Kim, BMJ Rana, JL Barlow, B Jones, TJ Haw, P Mono Nair, K Budden, GJM Cameron, JC Horvat, PA Wark, PS Foster, ANJ McKenzie, PM Hansbro Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease J. Leukoc. Biol., 2018-09-27;0(0):. 2018-09-27 [PMID: 30260499] (Mouse)
• HR Kim, Y Mun, KS Lee, YJ Park, JS Park, JH Park, BN Jeon, CH Kim, Y Jun, YM Hyun, M Kim, SM Lee, CS Park, SH Im, CD Jun T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells Nat Commun, 2018-09-07;9(1):3630. 2018-09-07 [PMID: 30194420] (Mouse)
• WY Chen, JL Yang, YH Wu, LC Li, RF Li, YT Chang, LH Dai, WC Wang, YJ Chang IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive renal injury Exp. Mol. Med., 2018-04-20;50(4):36. 2018-04-20 [PMID: 29674622] (Mouse)
• Y Ito, N Schaefer, A Sanchez, D Francisco, R Alam, RJ Martin, JG Ledford, C Stevenson, D Jiang, L Li, M Kraft, HW Chu Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice J Innate Immun, 2018-01-27;0(0):. 2018-01-27 [PMID: 29393212] (Mouse)
• E Dohi, EY Choi, IVL Rose, AS Murata, S Chow, M Niwa, SI Kano Behavioral Changes in Mice Lacking Interleukin-33 eNeuro, 2017-12-26;4(6):. 2017-12-26 [PMID: 29379874] (Mouse)
• MT Stier, K Goleniewsk, JY Cephus, DC Newcomb, TP Sherrill, KL Boyd, MH Bloodworth, ML Moore, K Chen, JK Kolls, RS Peebles STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection J. Immunol., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576981] (Mouse)
• C Li, I Maillet, C Mackowiak, C Viala, F Di Padova, M Li, D Togbe, V Quesniaux, Y Lai, B Ryffel Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells Cell Death Dis, 2017-04-06;8(4):e2735. 2017-04-06 [PMID: 28383552] (Mouse)
• Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis PLoS ONE, 2016-12-19;11(12):e0168080. 2016-12-19 [PMID: 27992569] (Mouse)
• Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9 PLoS ONE, 2016-12-15;11(12):e0167693. 2016-12-15 [PMID: 27977701] (Mouse)
• Ismé M de Kleer Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung Immunity, 2016-12-06;45(6):1285-1298. 2016-12-06 [PMID: 27939673] (Mouse)
• DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma JCI Insight, 2016-11-03;1(18):e88811. 2016-11-03 [PMID: 27812543] (Mouse)
• S Löser, LG Gregory, Y Zhang, K Schaefer, SA Walker, J Buckley, L Denney, CH Dean, WOC Cookson, MF Moffatt, CM Lloyd Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease J. Allergy Clin. Immunol., 2016-09-10;139(5):1496-1507.e3. 2016-09-10 [PMID: 27623174] (Mouse)
• Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation Nat Commun, 2016-09-01;7(0):12651. 2016-09-01 [PMID: 27582256] (Rat)
• Jovicic N, Jeftic I, Jovanovic I, Radosavljevic G, Arsenijevic N, Lukic M, Pejnovic N Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding. PLoS ONE, 2015-07-28;10(7):e0134089. 2015-07-28 [PMID: 26218873] (Mouse)
• Douglas T, Champagne C, Morizot A, Lapointe J, Saleh M The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice. J Immunol, 2015-07-27;195(5):2365-73. 2015-07-27 [PMID: 26216893] (Mouse)
• Verheijden K, Willemsen L, Braber S, Leusink-Muis T, Delsing D, Garssen J, Kraneveld A, Folkerts G Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model. Respir Res, 2015-02-07;16(0):17. 2015-02-07 [PMID: 25849971] (Mouse)
• Palomo J, Reverchon F, Piotet J, Besnard A, Couturier-Maillard A, Maillet I, Tefit M, Erard F, Mazier D, Ryffel B, Quesniaux V Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Eur J Immunol, 2015-03-20;45(5):1354-65. 2015-03-20 [PMID: 25682948] (Mouse)
• Verma , A, Kroetz , D N, Tweedle , J L, Deepe , G S Jr Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal Immunol, 2014-08-13;8(2):380-9. 2014-08-13 [PMID: 25118166] (Mouse)
• Spann K, Loh Z, Lynch J, Ullah A, Zhang V, Baturcam E, Werder R, Khajornjiraphan N, Rudd P, Loo Y, Suhrbier A, Gale M, Upham J, Phipps S IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. Am J Pathol, 2014-04-13;184(6):1795-806. 2014-04-13 [PMID: 24726644] (Mouse)
• Hams , Emily, Armstrong , Michelle, Barlow , Jillian, Saunders , Sean P, Schwartz , Christia, Cooke , Gordon, Fahy , Ruairi J, Crotty , Thomas B, Hirani , Nikhil, Flynn , Robin J, Voehringer , David, McKenzie , Andrew N, Donnelly , Seamas C, Fallon , Padraic IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A, 2013-12-16;111(1):367-72. 2013-12-16 [PMID: 24344271] (Mouse)
• Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagalv A, Schlenner S, Feyerabend T, Rodewald H, Kjellen L, Hellman L, Abrink M Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem, 2013-11-20;289(1):237-50. 2013-11-20 [PMID: 24257755] (Mouse)
• McHedlidze T, Waldner M, Zopf S, Walker J, Rankin A, Schuchmann M, Voehringer D, McKenzie A, Neurath M, Pflanz S, Wirtz S Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity, 2013-08-15;39(2):357-71. 2013-08-15 [PMID: 23954132] (Mouse)
• Kiwamoto T, Brummet M, Wu F, Motari M, Smith D, Schnaar R, Zhu Z, Bochner B Mice deficient in the St3gal3 gene product alpha2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. J Allergy Clin Immunol, 2013-07-02;133(1):240-7.e1-3. 2013-07-02 [PMID: 23830412] (Mouse)
• Kempuraj D, Twait E, Williard D, Yuan Z, Meyerholz D, Samuel I The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice. PLoS ONE, 2013-02-13;8(2):e56866. 2013-02-13 [PMID: 23418608] (Mouse, Rat)
• Wilson , Rhonda H, Maruoka , Shuichir, Whitehead , Gregory, Foley , Julie F, Flake , Gordon P, Sever , Michelle, Zeldin , Darryl C, Kraft , Monica, Garantziotis , Stavros, Nakano , Hideki, Cook , Donald N The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens. Nat Med, 2012-10-14;18(11):1705-10. 2012-10-14 [PMID: 23064463] (Mouse)
• Paulissen G, El Hour M, Rocks N, Gueders M, Bureau F, Foidart J, Lopez-Otin C, Noel A, Cataldo D Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12. J Immunol, 2012-09-07;189(8):4135-43. 2012-09-07 [PMID: 22962682] (Mouse)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Mouse)
• Enoksson M, Lyberg K, Moller-Westerberg C, Fallon PG, Nilsson G, Lunderius-Andersson C Mast cells as sensors of cell injury through IL-33 recognition. J. Immunol., 2011-01-14;186(4):2523-8. 2011-01-14 [PMID: 21239713] (Mouse)
• Kearley J, Buckland KF, Mathie SA, Lloyd CM Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am. J. Respir. Crit. Care Med., 2009-01-29;179(9):772-81. 2009-01-29 [PMID: 19179489] (Mouse)

FAQs for IL-33 (DY3626). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Il33