Mouse Endocan DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Endocan DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Esm1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Endocan DuoSet ELISA, 15 Plate

• Endocan
• endothelial cell-specific molecule 1
• ESM1
• ESM-1
• IGFBP-rp6

Background

Endocan, also known as Endothelial Cell-specific Molecule-1 (ESM-1) and IGFBP-rp6, is a secreted cysteine-rich dermatan sulfate proteoglycan. It is primarily expressed by endothelial cells within the vascular network of the kidney and in the alveolar walls of the lung. Endocan expression is upregulated by TNF-alpha, IL-1 beta and LPS, and downregulated by IFN-gamma. Endocan binds LFA-1 on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA-1-mediated leukocyte activation. Elevated circulating Endocan levels have been reported in patients with lung cancer and severe sepsis.

Publications for Endocan/ESM-1 (DY1999)(3)

Publications using DY1999

• Kurtz, SL;Baker, RE;Boehm, FJ;Lehman, CC;Mittereder, LR;Khan, H;Rossi, AP;Gatti, DM;Beamer, G;Sassetti, CM;Elkins, KL; Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in genetically diverse mice PLoS pathogens 2024-03-01 [PMID: 38452145] (Mouse)
• X Xie, D Chen, X Yang, Y Cao, Y Guo, W Cheng Combination of Maternal Serum ESM-1 and PLGF with Uterine Artery Doppler PI for Predicting Preeclampsia Journal of Clinical Medicine, 2023-01-06;12(2):. 2023-01-06 [PMID: 36675388] (Human)
• Czaikoski P, Mota J, Nascimento D, Sonego F, Castanheira F, Melo P, Scortegagna G, Silva R, Barroso-Sousa R, Souto F, Pazin-Filho A, Figueiredo F, Alves-Filho J, Cunha F Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS ONE, 2016-02-05;11(2):e0148142. 2016-02-05 [PMID: 26849138] (Mouse)

Bioinformatics

• Gene Symbol: Esm1