Mouse CXCL13/BLC/BCA-1 Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse CXCL13/BLC/BCA-1 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse BLC/BCA-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse BLC/BCA-1 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse BLC/BCA-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mou...se BLC/BCA-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse BLC/BCA-1.
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• Specificity: Natural and recombinant mouse BLC/BCA-1
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl13

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CXCL13/BLC/BCA-1 Quantikine ELISA Kit

• ANGIE
• ANGIE2
• B cell-attracting chemokine 1
• B lymphocyte chemoattractant
• BCA1
• BCA-1
• BCA1B-cell chemoattractant
• BCA-1CXC chemokine BLC
• B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
• BLC
• BLCSmall-inducible cytokine B13
• BLR1L
• B-lymphocyte chemoattractant
• chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
• chemokine (C-X-C motif) ligand 13
• C-X-C motif chemokine 13
• CXCL13
• SCYB13
• SCYB13B-cell-attracting chemokine 1
• small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

Background

CXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It can form homodimers or heterodimers with FGF basic, and it signals through CXCR3 or CXCR5. CXCL13 induces the migration of naïve B cells and a subset of memory T cells to lymphoid tissue. It also promotes B1 cell migration into the omentum and peritoneum. In the fetus, CXCL13 attracts CD4+ CD3- IL-7 R alpha+ hematopoietic cells to sites of future Peyer’s patch development.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CXCL13/BLC/BCA-1 (MCX130)(17)

Publications using MCX130

• Jin, Q;Zhang, C;Chen, R;Jiang, L;Li, H;Wu, P;Li, L; Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic Journal of translational medicine 2024-04-15 [PMID: 38622667] (Transgenic Mouse)
• Bekkat, F;Seradj, M;Lengagne, R;Fiore, F;Kato, M;Lucas, B;Castellano, F;Molinier-Frenkel, V;Richard, Y;Prévost-Blondel, A; Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties European journal of immunology 2024-02-24 [PMID: 38400692] (Mouse)
• EY Faraoni, BJ O'Brien, LN Strickland, BK Osborn, V Mota, J Chaney, CL Atkins, P Cen, J Rowe, J Cardenas, KL Poulsen, CJ Wray, NC Thosani, JM Bailey-Lun Radiofrequency Ablation Remodels the Tumor Microenvironment and Promotes Neutrophil-Mediated Abscopal Immunomodulation in Pancreatic Cancer Cancer Immunology Research, 2023-01-03;11(1):4-12. 2023-01-03 [PMID: 36367967] (Mouse)
• DG Franchina, H Kurniawan, M Grusdat, C Binsfeld, L Guerra, L Bonetti, L Soriano-Ba, A Ewen, T Kobayashi, S Farinelle, AR Minafra, N Vandamme, A Carpentier, FK Borgmann, C Jäger, Y Chen, M Kleinewiet, V Vasiliou, M Mittelbron, K Hiller, PA Lang, D Brenner Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells Nature Communications, 2022-04-04;13(1):1789. 2022-04-04 [PMID: 35379825] (Mouse)
• LD Owlett, B Karaahmet, L Le, EK Belcher, D Dionisio-S, JA Olschowka, MR Elliott, MK O'Banion Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease Journal of Neuroinflammation, 2022-02-07;19(1):38. 2022-02-07 [PMID: 35130912] (Mouse)
• Z Wang, J Hazen, X Jia, E Org, Y Zhao, LJ Osborn, N Nimer, J Buffa, MK Culley, D Krajcik, BH van den Bo, K Zwinderman, BS Levison, M Nieuwdorp, AJ Lusis, JA DiDonato, SL Hazen The Nutritional Supplement L-Alpha Glycerylphosphorylcholine Promotes Atherosclerosis International Journal of Molecular Sciences, 2021-12-15;22(24):. 2021-12-15 [PMID: 34948275] (Mouse)
• Y Itatani, T Yamamoto, C Zhong, AA Molinolo, J Ruppel, P Hegde, MM Taketo, N Ferrara Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer Proc. Natl. Acad. Sci. U.S.A., 2020-08-19;0(0):. 2020-08-19 [PMID: 32817421] (Mouse)
• Y Huang, Y Chen, S Zhou, L Chen, J Wang, Y Pei, M Xu, J Feng, T Jiang, K Liang, S Liu, Q Song, G Jiang, X Gu, Q Zhang, X Gao, J Chen Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors Nat Commun, 2020-01-30;11(1):622. 2020-01-30 [PMID: 32001695] (Mouse)
• PC Duncker, JS Stoolman, AK Huber, BM Segal GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction J. Immunol., 2017-12-29;0(0):. 2017-12-29 [PMID: 29288202] (Mouse)
• Brain inflammation is accompanied by peripheral inflammation in Cstb (-/-) mice, a model for progressive myoclonus epilepsy J Neuroinflammation, 2016-11-28;13(1):298. 2016-11-28 [PMID: 27894304] (Mouse)
• Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Cancer Discov, 2015-12-29;6(3):256-69. 2015-12-29 [PMID: 26715642] (Mouse)
• Carroll J, Striebel J, Race B, Phillips K, Chesebro B Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction. J Virol, 2014-12-10;89(4):2388-404. 2014-12-10 [PMID: 25505076] (Mouse)
• Monson N, Ortega S, Ireland S, Meeuwissen A, Chen D, Plautz E, Shubel E, Kong X, Li M, Freriks L, Stowe A Repetitive hypoxic preconditioning induces an immunosuppressed B cell phenotype during endogenous protection from stroke. J Neuroinflammation, 2014-01-31;11(0):22. 2014-01-31 [PMID: 24485041] (Mouse)
• Grabner R, Lotzer K, Dopping S, Hildner M, Radke D, Beer M, Spanbroek R, Lippert B, Reardon CA, Getz GS, Fu YX, Hehlgans T, Mebius RE, van der Wall M, Kruspe D, Englert C, Lovas A, Hu D, Randolph GJ, Weih F, Habenicht AJ Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J. Exp. Med., 2009-01-12;206(1):233-48. 2009-01-12 [PMID: 19139167] (Mouse)
• Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J. Immunol., 2008-10-15;181(8):5360-7. 2008-10-15 [PMID: 18832692] (Mouse)
• Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am. J. Pathol., 2007-04-01;170(4):1152-64. 2007-04-01 [PMID: 17392156] (Mouse)
• Martin AP, Canasto-Chibuque C, Shang L, Rollins BJ, Lira SA The chemokine decoy receptor M3 blocks CC chemokine ligand 2 and CXC chemokine ligand 13 function in vivo. J. Immunol., 2006-11-15;177(10):7296-302. 2006-11-15 [PMID: 17082648] (Mouse)

Bioinformatics

• Gene Symbol: Cxcl13