Mouse CXCL13/BLC/BCA-1 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse CXCL13/BLC/BCA-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl13

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CXCL13/BLC/BCA-1 DuoSet ELISA, 15 Plate

• ANGIE
• ANGIE2
• B cell-attracting chemokine 1
• B lymphocyte chemoattractant
• BCA1
• BCA-1
• BCA1B-cell chemoattractant
• BCA-1CXC chemokine BLC
• B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
• BLC
• BLCSmall-inducible cytokine B13
• BLR1L
• B-lymphocyte chemoattractant
• chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
• chemokine (C-X-C motif) ligand 13
• C-X-C motif chemokine 13
• CXCL13
• SCYB13
• SCYB13B-cell-attracting chemokine 1
• small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

Background

CXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It can form homodimers or heterodimers with FGF basic, and it signals through CXCR3 or CXCR5. CXCL13 induces the migration of naïve B cells and a subset of memory T cells to lymphoid tissue. It also promotes B1 cell migration into the omentum and peritoneum. In the fetus, CXCL13 attracts CD4+ CD3- IL-7 R alpha+ hematopoietic cells to sites of future Peyer’s patch development.

Publications for CXCL13/BLC/BCA-1 (DY470)(17)

Publications using DY470

• Morgaenko, K;Arneja, A;Ball, AG;Putelo, AM;Munson, JM;Rutkowski, MR;Pompano, RR; Ex vivo model of breast cancer cell invasion in live lymph node tissue bioRxiv : the preprint server for biology 2024-07-22 [PMID: 39091774] (Mouse)
• Armstrong, D;Chang, CY;Hong, MJ;Green, L;Hudson, W;Shen, Y;Song, LZ;Jammi, S;Casal, B;Creighton, CJ;Carisey, A;Zhang, XH;McKenna, NJ;Kang, SW;Lee, HS;Corry, DB;Kheradmand, F; MAGE-A4-Responsive Plasma Cells Promote Non-Small Cell Lung Cancer bioRxiv : the preprint server for biology 2024-07-16 [PMID: 39071307] (Mouse)
• Osorio, JC;Knorr, DA;Weitzenfeld, P;Yao, N;Baez, M;DiLillo, M;Rahman, J;Bromberg, J;Postow, MA;Ariyan, C;Robson, ME;Ravetch, JV; Intratumoral Fc-optimized agonistic CD40 antibody induces tumor rejection and systemic antitumor immunity in patients with metastatic cancer Research square 2024-06-03 [PMID: 38883779] (Transgenic Mouse)
• Hopkin, SJ;Pezhman, L;Begum, J;Kavanagh, D;McGettrick, HM;Iqbal, AJ;Chimen, M; Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner Journal of leukocyte biology 2023-06-13 [PMID: 37309034] (Mouse)
• L Ji, T Wang, L Tian, H Song, M Gao Roxatidine inhibits fibrosis by inhibiting NF?kappaB and MAPK signaling in macrophages sensing breast implant surface materials Mol Med Rep, 2019-11-12;0(0):. 2019-11-12 [PMID: 31746427] (Mouse)
• S Carvalho, M Ferrini, L Herritt, A Holian, Z Jaffar, K Roberts Multi-Walled Carbon Nanotubes Augment Allergic Airway Eosinophilic Inflammation by Promoting Cysteinyl Leukotriene Production Front Pharmacol, 2018-06-05;9(0):585. 2018-06-05 [PMID: 29922162] (Mouse)
• K Bröker, J Figge, AF Magnusen, RA Manz, J Köhl, CM Karsten A Novel Role for C5a in B-1 Cell Homeostasis Front Immunol, 2018-02-19;9(0):258. 2018-02-19 [PMID: 29520270] (Mouse)
• W Alturaiki, AJ McFarlane, K Rose, R Corkhill, PS McNamara, J Schwarze, BF Flanagan Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of Respiratory Syncytial Virus infection Cytokine, 2018-02-01;0(0):. 2018-02-01 [PMID: 29396045] (Mouse)
• A Gutjahr, L Papagno, F Nicoli, A Lamoureux, F Vernejoul, T Lioux, E Gostick, DA Price, G Tiraby, E Perouzel, V Appay, B Verrier, S Paul Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses J. Immunol., 2017-04-21;0(0):. 2017-04-21 [PMID: 28432147] (Mouse)
• CXCL13 is a plasma biomarker of germinal center activity Proc. Natl. Acad. Sci. U.S.A., 2016-02-23;113(10):2702-7. 2016-02-23 [PMID: 26908875] (Mouse)
• Neill , Daniel R, Saint , Gemma L, Bricio-Moreno , Laura, Fothergill , Joanne L, Southern , Kevin W, Winstanley , Craig, Christmas , Stephen, Slupsky , Joseph R, McNamara , Paul S, Kadioglu , Aras, Flanagan , Brian F The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa. PLoS ONE, 2014-05-21;9(5):e95892. 2014-05-21 [PMID: 24847941] (Mouse)
• Paradis M, Mindt B, Duerr C, Rojas O, Ng D, Boulianne B, McCarthy D, Yu M, Summers deLuca L, Ward L, Waldron J, Philpott D, Gommerman J, Fritz J A TNF-alpha-CCL20-CCR6 axis regulates Nod1-induced B cell responses. J Immunol, 2014-02-17;192(6):2787-99. 2014-02-17 [PMID: 24534531] (Mouse)
• Slight S, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko B, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart T, Randall T, Khader S CXCR5(+) T helper cells mediate protective immunity against tuberculosis. J Clin Invest, 2013-01-02;123(2):712-26. 2013-01-02 [PMID: 23281399] (Mouse)
• Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson JA, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host. PLoS Pathog., 2011-03-17;7(3):e1001321. 2011-03-17 [PMID: 21445235] (Mouse)
• Suto H, Katakai T, Sugai M, Kinashi T, Shimizu A CXCL13 production by an established lymph node stromal cell line via lymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways. Int. Immunol., 2009-02-27;21(4):467-76. 2009-02-27 [PMID: 19251935] (Mouse)
• Demoor T, Bracke KR, Maes T, Vandooren B, Elewaut D, Pilette C, Joos GF, Brusselle GG Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis. Eur. Respir. J., 2009-01-22;34(2):405-16. 2009-01-22 [PMID: 19164352] (Mouse)
• Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J. Immunol., 2008-11-01;181(9):6189-200. 2008-11-01 [PMID: 18941209] (Mouse)

Bioinformatics

• Gene Symbol: Cxcl13