Mouse CXCL12/SDF-1 alpha Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse CXCL12/SDF-1 alpha Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse SDF-1 alpha Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse SDF-1 alpha in cell culture supernates and mouse serum. It contains E. coli-expressed recombinant mouse SDF-1 alpha and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant mouse SDF-1 alpha. Results obtained using natural SDF-1 a...lpha showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of natural mouse SDF-1 alpha.
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• Specificity: Natural and recombinant mouse SDF-1 alpha
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl12

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CXCL12/SDF-1 alpha Quantikine ELISA Kit

• CXCL12 chemokine (C-X-C motif) ligand 12
• CXCL12/SDF-1 alpha
• IRH
• PBSF
• SCYB12
• SDF1 alpha
• SDF1
• SDF1a
• SDF1B
• TLSF
• TPAR1

Background

CXCL12/Stromal Cell-derived Factor 1 (SDF-1) is a member of the CXC chemokine ligand superfamily. Six alternatively spliced CXCL12/SDF-1 isoforms have been identified including, CXCL12/SDF-1 alpha, CXCL12/SDF-1 beta, and CXCL12/SDF-1 gamma. CXCL12/SDF-1 alpha is 89 amino acids (aa) in length with a predicted molecular weight of 10 kDa, CXCL12/SDF-1 beta is 93 aa in length with a predicted molecular weight of 10.6 kDa, and CXCL12/SDF-1 gamma is 119 aa in length with a predicted molecular weight of 13.7 kDa. The mouse CXCL12/SDF-1 orthologs share 99% aa sequence identity with the human protein. The alpha and beta isoforms are ubiquitously expressed while the gamma isoform is primarily expressed in the heart. CXCL12/SDF-1 isoforms are chemotactic for T lymphocytes and monocytes. It is cardio protective and has also been shown to hinder CXCR4-mediated HIV infection of T cells.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CXCL12/SDF-1 alpha (MCX120)(91)

Publications using MCX120

• Lee, D;Benvie, AM;Steiner, BM;Kolba, NJ;Ford, JG;McCabe, SM;Jiang, Y;Berry, DC; Smooth muscle cell-derived Cxcl12 directs macrophage accrual and sympathetic innervation to control thermogenic adipose tissue Cell reports 2024-04-27 [PMID: 38678562] (Mouse)
• Bekkat, F;Seradj, M;Lengagne, R;Fiore, F;Kato, M;Lucas, B;Castellano, F;Molinier-Frenkel, V;Richard, Y;Prévost-Blondel, A; Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties European journal of immunology 2024-02-24 [PMID: 38400692] (Mouse)
• Takeishi, S;Marchand, T;Koba, WR;Borger, DK;Xu, C;Guha, C;Bergman, A;Frenette, PS;Gritsman, K;Steidl, U; Haematopoietic stem cell numbers are not solely determined by niche availability bioRxiv : the preprint server for biology 2023-10-29 [PMID: 37961493] (Mouse, Transgenic Mouse)
• Pham, HTT;Magez, S;Choi, B;Baatar, B;Jung, J;Radwanska, M; Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis Nature communications 2023-09-05 [PMID: 37669943] (Mouse)
• SY Heazlewood, T Ahmad, B Cao, H Cao, M Domingues, X Sun, CK Heazlewood, S Li, B Williams, M Fulton, JF White, T Nebl, CM Nefzger, JM Polo, BT Kile, F Kraus, MT Ryan, YB Sun, PFM Choong, SL Ellis, ML Anko, SK Nilsson High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production Nature Communications, 2023-04-13;14(1):2099. 2023-04-13 [PMID: 37055407] (Mouse)
• S Luo, C Liao, L Zhang, C Ling, X Zhang, P Xie, G Su, Z Chen, L Zhang, T Lai, J Tang METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling Cell Reports, 2023-03-14;42(3):112259. 2023-03-14 [PMID: 36920907] (Mouse)
• Y Omatsu, S Aiba, T Maeta, K Higaki, K Aoki, H Watanabe, G Kondoh, R Nishimura, S Takeda, UI Chung, T Nagasawa Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells Nature Communications, 2022-05-12;13(1):2654. 2022-05-12 [PMID: 35551452] (Mouse)
• P Wolinski, D Ksiazek-Wi, A Glabinski Cytokines and Neurodegeneration in Epileptogenesis Brain sciences, 2022-03-12;12(3):. 2022-03-12 [PMID: 35326336] (Mouse)
• N Zhang, Q Ma, Y You, X Xia, C Xie, Y Huang, Z Wang, F Ye, Z Yu, X Xie CXCR4-dependent macrophage-to-fibroblast signaling contributes to cardiac diastolic dysfunction in heart failure with preserved ejection fraction International journal of biological sciences, 2022-01-09;18(3):1271-1287. 2022-01-09 [PMID: 35173552] (Mouse)
• L Pouzol, A Sassi, N Baumlin, M Tunis, DS Strasser, F Lehembre, MM Martinic CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis Oncogene, 2021-11-05;12(0):748740. 2021-11-05 [PMID: 34803691] (Mouse)
• R Molina-Peñ, M Haji Manso, M Najberg, JM Thomassin, B Gueza, C Alvarez-Lo, E Garcion, C Jérôme, F Boury Nanoparticle-containing Electrospun Nanofibrous Scaffolds for Sustained Release of SDF-1alpha International journal of pharmaceutics, 2021-10-17;0(0):121205. 2021-10-17 [PMID: 34670119] (Mouse)
• A Gatsiou, K Sopova, A Tselepis, K Stellos Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State Cells, 2021-07-22;10(8):. 2021-07-22 [PMID: 34440624] (Human)
• W Guan, F Li, Z Zhao, Z Zhang, J Hu, Y Zhang Tumor-Associated Macrophage Promotes the Survival of Cancer Cells upon Docetaxel Chemotherapy via the CSF1/CSF1R-CXCL12/CXCR4 Axis in Castration-Resistant Prostate Cancer Genes, 2021-05-19;12(5):. 2021-05-19 [PMID: 34069563] (Mouse)
• S Gencer, Y Döring, Y Jansen, S Bayasgalan, O Schengel, M Müller, LJF Peters, C Weber, EPC van der Vo Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue Biomedicines, 2021-04-06;9(4):. 2021-04-06 [PMID: 33917642] (Mouse)
• AA Hastreiter, GG Dos Santos, EN Makiyama, EWC Santos, P Borelli, RA Fock Effects of protein malnutrition on haematopoietic regulatory activity of bone marrow mesenchymal stem cells The Journal of nutritional biochemistry, 2021-03-08;0(0):108626. 2021-03-08 [PMID: 33705953] (Mouse)
• Q Dai, X Fan, X Meng, S Sun, Y Su, X Ling, X Chen, K Wang, X Dai, C Zhang, S Da, G Zhang, C Gu, H Chen, J He, H Hu, L Yu, X Pan, Y Tan, X Yan FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+-dependent manner Journal of Cellular and Molecular Medicine, 2021-02-17;0(0):. 2021-02-17 [PMID: 33599110] (Mouse)
• RS Carpenter, JM Marbourg, FH Brennan, KA Mifflin, JCE Hall, RR Jiang, XM Mo, M Karunasiri, MH Burke, AM Dorrance, PG Popovich Spinal cord injury causes chronic bone marrow failure Nat Commun, 2020-07-24;11(1):3702. 2020-07-24 [PMID: 32710081] (Mouse)
• Y Zhu, T Hirata, F Mackay, F Murakami Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation Sci Rep, 2020-07-16;10(1):11830. 2020-07-16 [PMID: 32678266] (Mouse)
• S Sinha, M Biswas, SS Chatterjee, S Kumar, A Sengupta Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-&beta Signaling Cell Rep, 2020-04-28;31(4):107570. 2020-04-28 [PMID: 32348751] (Mouse)
• Z Sun, Y Xie, RJ Lee, Y Chen, Q Jin, Q Lv, J Wang, Y Yang, Y Li, Y Cai, R Wang, Z Han, L Zhang, M Xie Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction Theranostics, 2020-04-06;10(11):4967-4982. 2020-04-06 [PMID: 32308762] (Rat)
• CC Hsiao, CC Lin, YS Hou, JY Ko, CJ Wang Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model Int J Mol Sci, 2019-10-05;20(19):. 2019-10-05 [PMID: 31590394] (Rat)
• YZ Zhou, Z Cheng, Y Wu, QY Wu, XB Liao, Y Zhao, JM Li, XM Zhou, XM Fu Mesenchymal stem cell-derived conditioned medium attenuate angiotensin II-induced aortic aneurysm growth by modulating macrophage polarization J. Cell. Mol. Med., 2019-10-04;0(0):. 2019-10-04 [PMID: 31583844] (Mouse)
• M Stenzinger, D Karpova, C Unterraine, S Harenkamp, E Wiercinska, K Hoerster, M Pfeffer, E Maronde, H Bonig Hematopoietic-Extrinsic Cues Dictate Circadian Redistribution of Mature and Immature Hematopoietic Cells in Blood and Spleen Cells, 2019-09-05;8(9):. 2019-09-05 [PMID: 31491915] (Mouse)
• Y Martín-Mar, L Fernández-, MH Sanchez-Re, N Marí-Buyé, FJ Rojo, J Pérez-Rigu, M Ramos, GV Guinea, F Panetsos, D González-N Evaluation of Neurosecretome from Mesenchymal Stem Cells Encapsulated in Silk Fibroin Hydrogels Sci Rep, 2019-06-19;9(1):8801. 2019-06-19 [PMID: 31217546] (Mouse)
• K Kurita, K Ishikawa, K Takeda, M Fujimoto, H Ono, J Kumagai, H Inoue, H Yokoh, K Yokote CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet Sci Rep, 2019-04-16;9(1):6165. 2019-04-16 [PMID: 30992469] (Mouse)
• A Girousse, M Gil-Ortega, V Bourlier, C Bergeaud, Q Sastourné-, C Moro, C Barreau, C Guissard, J Vion, E Arnaud, JP Pradère, N Juin, L Casteilla, C Sengenès The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition Cell Rep, 2019-04-09;27(2):323-333.e5. 2019-04-09 [PMID: 30970240] (Mouse)
• MJ Costa, J Kudaravall, JT Ma, WH Ho, K Delaria, C Holz, A Stauffer, AG Chunyk, Q Zong, E Blasi, B Buetow, TT Tran, K Lindquist, M Dorywalska, A Rajpal, DL Shelton, P Strop, SH Liu Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates Sci Rep, 2019-02-21;9(1):2443. 2019-02-21 [PMID: 30792442] (Mouse)
• RL Openshaw, J Kwon, A McColl, JM Penninger, J Cavanagh, JA Pratt, BJ Morris JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk J Neuroinflammation, 2019-01-28;16(1):18. 2019-01-28 [PMID: 30691477] (Mouse)
• MA Nishiguchi, CA Spencer, DH Leung, TH Leung Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration Cell Rep, 2018-09-25;24(13):3383-3392.e5. 2018-09-25 [PMID: 30257200] (Mouse)
• ME Alvarèz Fa, M Piccoli, C Franzin, A Sgrò, A Dedja, L Urbani, E Bertin, C Trevisan, P Gamba, AJ Burns, P De Coppi, M Pozzobon Decellularized Diaphragmatic Muscle Drives a Constructive Angiogenic Response In Vivo Int J Mol Sci, 2018-04-28;19(5):. 2018-04-28 [PMID: 29710813] (Mouse)
• RM Natoli, H Yu, MC Meislin, P Abbasnia, P Roper, A Vuchkovska, X Xiao, SR Stock, JJ Callaci Alcohol exposure decreases osteopontin expression during fracture healing and osteopontin-mediated mesenchymal stem cell migration in vitro J Orthop Surg Res, 2018-04-27;13(1):101. 2018-04-27 [PMID: 29699560] (Mouse)
• M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695634] (Mouse)
• ME Ogle, JR Krieger, LE Tellier, J McFaline-F, JS Temenoff, EA Botchwey Dual Affinity Heparin-Based Hydrogels Achieve Pro-Regenerative Immunomodulation and Microvascular Remodeling ACS Biomater Sci Eng, 2017-02-20;4(4):1241-1250. 2017-02-20 [PMID: 29682605] (Mouse)
• J Shin, A Fukuhara, T Onodera, S Kita, C Yokoyama, M Otsuki, I Shimomura SDF-1 is an Autocrine Insulin-Desensitizing Factor in Adipocytes Diabetes, 2018-03-26;0(0):. 2018-03-26 [PMID: 29581126] (ELISA Capture, Mouse)
• MJ Costa, J Kudaravall, WH Liu, J Stock, S Kong, SH Liu A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics PLoS ONE, 2018-03-19;13(3):e0194688. 2018-03-19 [PMID: 29554149] (Mouse)
• L Notario, E Alari-Pahi, A Albentosa, M Leiva, G Sabio, P Lauzurica Anti-CD69 therapy induces rapid mobilization and high proliferation of HSPCs through S1P and mTOR Leukemia, 2018-02-27;0(0):. 2018-02-27 [PMID: 29483712] (Mouse)
• P Chang, B Zhang, L Shao, W Song, W Shi, L Wang, T Xu, D Li, X Gao, Y Qu, L Dong, J Wang Mesenchymal stem cells over-expressing cxcl12 enhance the radioresistance of the small intestine Cell Death Dis, 2018-02-05;9(2):154. 2018-02-05 [PMID: 29402989] (Mouse)
• K Fujiwara, T Inoue, Y Henmi, Y Hirata, Y Naka, A Hara, K Kakimoto, S Nouda, T Okada, K Kawakami, T Takeuchi, K Higuchi Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in Apc(Min/+) mice fed a high-fat diet Oncol Lett, 2017-08-01;14(4):4355-4360. 2017-08-01 [PMID: 28943949] (Mouse)
• S Swami, J Johnson, LA Bettinson, T Kimura, H Zhu, MA Albertelli, RW Johnson, JY Wu Prevention of breast cancer skeletal metastases with parathyroid hormone JCI Insight, 2017-09-07;2(17):. 2017-09-07 [PMID: 28878134] (Mouse)
• S Seemann, F Zohles, A Lupp Comprehensive comparison of three different animal models for systemic inflammation J. Biomed. Sci., 2017-08-24;24(1):60. 2017-08-24 [PMID: 28836970] (Mouse)
• X Dai, J Zeng, X Yan, Q Lin, K Wang, J Chen, F Shen, X Gu, Y Wang, J Chen, K Pan, L Cai, KA Wintergers, Y Tan Sitagliptin-mediated preservation of endothelial progenitor cell function via augmenting autophagy enhances ischaemic angiogenesis in diabetes J. Cell. Mol. Med., 2017-08-10;0(0):. 2017-08-10 [PMID: 28799229] (Mouse)
• C Freitas, M Wittner, J Nguyen, V Rondeau, V Biajoux, ML Aknin, F Gaudin, S Beaussant-, Y Bertrand, C Bellanné-C, J Donadieu, F Bachelerie, M Espéli, A Dalloul, F Louache, K Balabanian Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization J. Exp. Med., 2017-05-26;0(0):. 2017-05-26 [PMID: 28550161] (Mouse)
• J Chen, M Zhang, F Zhou, J Wang, B Niu, W Zhang Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model Oncol Lett, 2017-02-13;13(4):2323-2329. 2017-02-13 [PMID: 28454398] (Mouse)
• N Sanadgol, F Golab, Z Tashakkor, N Taki, S Moradi Kou, A Mostafaie, M Mehdizadeh, M Abdollahi, G Taghizadeh, M Sharifzade Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis Pharm Biol, 2017-12-01;55(1):1679-1687. 2017-12-01 [PMID: 28447514] (Mouse)
• R Cinar, BR Gochuico, MR Iyer, T Jourdan, T Yokoyama, JK Park, NJ Coffey, H Pri-Chen, G Szanda, Z Liu, K Mackie, WA Gahl, G Kunos Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis JCI Insight, 2017-04-20;2(8):. 2017-04-20 [PMID: 28422760] (Mouse)
• S Colié, S Sarroca, R Palenzuela, I Garcia, A Matheu, R Corpas, CG Dotti, JA Esteban, C Sanfeliu, AR Nebreda Neuronal p38? mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling ?-amyloid production Sci Rep, 2017-03-31;7(0):45306. 2017-03-31 [PMID: 28361984] (Mouse)
• Sphingosine-1-phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence within the Bone Marrow Niche Stem Cells, 2017-01-19;0(0):. 2017-01-19 [PMID: 28026131] (Mouse)
• The DPP4 Inhibitor Linagliptin Protects from Experimental Diabetic Retinopathy PLoS ONE, 2016-12-12;11(12):e0167853. 2016-12-12 [PMID: 27942008] (Mouse, Rat)
• Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration J Leukoc Biol, 2016-08-16;0(0):. 2016-08-16 [PMID: 27531927] (Mouse)
• Chang T, Wu T, Huang P, Lin C, Chen J, Lin L, Lin S, Chen J Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism. PLoS ONE, 2015-08-25;10(8):e0136627. 2015-08-25 [PMID: 26305217] (Mouse)
• Toyoshima A, Yasuhara T, Kameda M, Morimoto J, Takeuchi H, Wang F, Sasaki T, Sasada S, Shinko A, Wakamori T, Okazaki M, Kondo A, Agari T, Borlongan C, Date I Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms. PLoS ONE, 2015-06-15;10(6):e0127302. 2015-06-15 [PMID: 26075717] (Rat)
• Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu V, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden D, Stanley P, Lowe J, Huang A, Siebel C, Zhou L Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem Cells, 2015-05-13;33(7):2280-93. 2015-05-13 [PMID: 25851125] (Mouse)
• Iinuma S, Aikawa E, Tamai K, Fujita R, Kikuchi Y, Chino T, Kikuta J, McGrath J, Uitto J, Ishii M, Iizuka H, Kaneda Y Transplanted bone marrow-derived circulating PDGFRalpha+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft. J Immunol, 2015-01-19;194(4):1996-2003. 2015-01-19 [PMID: 25601922] (Mouse)
• Iyer S, Brooks R, Gumbleton M, Kerr W SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging. Stem Cells Dev, 2015-02-05;24(9):1073-81. 2015-02-05 [PMID: 25525673] (Mouse)
• Shen K, Luk S, Hicks D, Elman J, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush M, Toner M, Sgroi D, Parekkadan B Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun, 2014-12-09;5(0):5662. 2014-12-09 [PMID: 25489927] (Mouse)
• Watson H, Holley R, Langford-Smith K, Wilkinson F, van Kuppevelt T, Wynn R, Wraith J, Merry C, Bigger B Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I. J Biol Chem, 2014-10-30;289(52):36194-203. 2014-10-30 [PMID: 25359774] (Mouse)
• Wei F, Leung K, Li G, Qin J, Chow S, Huang S, Sun M, Qin L, Cheung W Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. PLoS ONE, 2014-09-02;9(9):e106722. 2014-09-02 [PMID: 25181476] (Rat)
• Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment. Sci Rep, 2014-08-28;4(0):6222. 2014-08-28 [PMID: 25164363] (Mouse)
• Malliaras K, Ibrahim A, Tseliou E, Liu W, Sun B, Middleton R, Seinfeld J, Wang L, Sharifi B, Marban E Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol Med, 2014-04-06;6(6):760-77. 2014-04-06 [PMID: 24797668] (Mouse)
• Fleige H, Ravens S, Moschovakis G, Bolter J, Willenzon S, Sutter G, Haussler S, Kalinke U, Prinz I, Forster R IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med, 2014-03-24;211(4):643-51. 2014-03-24 [PMID: 24663215] (Mouse)
• Fu S, Pang H, Xu J, Wu X C/EBPbeta mediates osteoclast recruitment by regulating endothelial progenitor cell expression of SDF-1alpha. PLoS ONE, 2014-03-11;9(3):e91217. 2014-03-11 [PMID: 24618682] (Mouse)
• Mocco J, Afzal A, Ansari S, Wolfe A, Caldwell K, Connolly E, Scott E SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia. PLoS ONE, 2014-01-20;9(1):e85615. 2014-01-20 [PMID: 24465621] (Mouse)
• Vadakke Madathil S, Coe L, Casu C, Sitara D Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis. Am J Pathol, 2014-01-08;184(3):827-41. 2014-01-08 [PMID: 24412515] (Mouse)
• Cao , Zhiqiang, Zhang , Geng, Wang , Fuli, Liu , Hongbao, Liu , Long, Han , Yaling, Zhang , Jian, Yuan , Jianlin Protective effects of mesenchymal stem cells with CXCR4 up-regulation in a rat renal transplantation model. PLoS ONE, 2013-12-30;8(12):e82949. 2013-12-30 [PMID: 24386129] (Mouse)
• Hoellenriegel J, Zboralski D, Maasch C, Rosin N, Wierda W, Keating M, Kruschinski A, Burger J The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. Blood, 2013-11-25;123(7):1032-9. 2013-11-25 [PMID: 24277076] (Mouse)
• Shu , Hui-Kuo, Yoon , Younghyo, Hong , Samuel, Xu , Kaiming, Gao , Huiying, Hao , Chunhai, Torres-Gonzalez , Edilson, Nayra , Cardenes, Rojas , Mauricio, Shim , Hyunsuk Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis. PLoS ONE, 2013-11-07;8(11):e79768. 2013-11-07 [PMID: 24244561] (Mouse)
• Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaor-Kondo A, Maekawa T CCAAT/enhancer-binding protein beta expressed by bone marrow mesenchymal stromal cells regulates early B-cell lymphopoiesis. Stem Cells, 2014-03-01;32(3):730-40. 2014-03-01 [PMID: 24115241] (Mouse)
• Stuelten C, Cervoni-Curet F, Busch J, Sutton E, Webster J, Kavalukas S, Wakefield L, Barbul A, Niederhuber J SDF-1alpha mediates wound-promoted tumor growth in a syngeneic orthotopic mouse model of breast cancer. PLoS ONE, 2013-04-11;8(4):e60919. 2013-04-11 [PMID: 23593347] (Mouse)
• Lin H, Chen Y, Chiang M, Huang P, Chau L Activator protein-2alpha mediates carbon monoxide-induced stromal cell-derived factor-1alpha expression and vascularization in ischemic heart. Arterioscler Thromb Vasc Biol, 2013-02-07;33(4):785-94. 2013-02-07 [PMID: 23393395] (Mouse)
• Fukuda H, Mochizuki S, Abe H, Okano HJ, Hara-Miyauchi C, Okano H, Yamaguchi N, Nakayama M, D'Armiento J, Okada Y Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production. Br. J. Cancer, 2011-10-20;105(10):1615-24. 2011-10-20 [PMID: 22015555] (Mouse)
• Arcangeli ML, Frontera V, Bardin F, Obrados E, Adams S, Chabannon C, Schiff C, Mancini SJ, Adams RH, Aurrand-Lions M JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood, 2011-08-25;118(17):4609-19. 2011-08-25 [PMID: 21868569] (Mouse)
• Oladipupo SS, Hu S, Santeford AC, Yao J, Kovalski JR, Shohet RV, Maslov K, Wang LV, Arbeit JM Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. Blood, 2011-02-09;117(15):4142-53. 2011-02-09 [PMID: 21307392] (Human, Mouse)
• Restivo TE, Mace KA, Harken AH, Young DM Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model. J Trauma, 2010-08-01;69(2):392-8. 2010-08-01 [PMID: 20699749] (Mouse)
• Ratajczak MZ, Lee H, Wysoczynski M, Wan W, Marlicz W, Laughlin MJ, Kucia M, Janowska-Wieczorek A, Ratajczak J Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. Leukemia, 2010-04-01;24(5):976-85. 2010-04-01 [PMID: 20357827] (Mouse)
• Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Int. J. Cancer, 2010-03-15;126(6):1302-15. 2010-03-15 [PMID: 19821487] (Mouse)
• Sayyed SG, Hagele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia, 2009-08-26;52(11):2445-54. 2009-08-26 [PMID: 19707743] (Mouse)
• Suh HC, Ji M, Gooya J, Lee M, Klarmann KD, Keller JR Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche. Blood, 2009-05-28;114(6):1186-95. 2009-05-28 [PMID: 19478045] (Mouse)
• Li N, Lu X, Zhao X, Xiang FL, Xenocostas A, Karmazyn M, Feng Q Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha. Stem Cells, 2009-04-01;27(4):961-70. 2009-04-01 [PMID: 19353524] (Mouse)
• Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R, Fischer R, Krieg L, Hirsch E, Huber B, Nathan P, Israel L, Imhof A, Herbach N, Assmann G, Wanke R, Mueller-Hoecker J, Steinbeck G, Franz WM Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell, 2009-04-03;4(4):313-23. 2009-04-03 [PMID: 19341621] (Mouse)
• Schroeter MR, Humboldt T, Schafer K, Konstantinides S Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice. Atherosclerosis, 2008-11-25;205(1):63-73. 2008-11-25 [PMID: 19111832] (Mouse)
• Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J. Cell Biol., 2008-12-15;183(6):1145-57. 2008-12-15 [PMID: 19075116] (Mouse)
• Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell, 2008-09-09;14(3):263-73. 2008-09-09 [PMID: 18772115] (Mouse)
• Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur. J. Pharmacol., 2008-06-16;590(1):400-8. 2008-06-16 [PMID: 18598692] (Mouse)
• Lin HH, Chen YH, Chang PF, Lee YT, Yet SF, Chau LY Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1. J. Mol. Cell. Cardiol., 2008-05-02;45(1):44-55. 2008-05-02 [PMID: 18534615] (Mouse)
• Migliaccio AR, Martelli F, Verrucci M, Migliaccio G, Vannucchi AM, Ni H, Xu M, Jiang Y, Nakamoto B, Papayannopoulou T, Hoffman R Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease. Exp. Hematol., 2008-02-01;36(2):158-71. 2008-02-01 [PMID: 18206727] (Mouse)
• Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74. 2007-10-17 [PMID: 17942672] (Mouse)
• Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J. Immunol., 2007-06-15;178(12):8148-57. 2007-06-15 [PMID: 17548653] (Mouse)
• Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2. Am. J. Physiol. Lung Cell Mol. Physiol., 2006-08-04;291(6):L1159-68. 2006-08-04 [PMID: 16891392] (Mouse, Rat)
• Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. J. Mol. Cell. Cardiol., 2006-05-05;41(1):34-43. 2006-05-05 [PMID: 16678199] (Mouse)
• Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood, 2004-09-28;105(3):931-9. 2004-09-28 [PMID: 15454484] (Mouse)
• Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 2002-05-31;109(5):625-37. 2002-05-31 [PMID: 12062105] (Mouse)

Bioinformatics

• Gene Symbol: Cxcl12