Mouse Chitinase 3-like 1/YKL-40 Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse Chitinase 3-like 1/YKL-40 Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse CHI3L1 immunoassay is a 4.5 hour solid-phase ELISA designed to measure CHI3L1 in cell culture supernates, mouse serum, and plasma. It contains NS0-expressed recombinant mouse CHI3L1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse CHI3L1. Results obtained using natural mouse CHI3L1 showed... dose response curves that were parallel to the standard curves obtained using the Quantikine mouse kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse CHI3L1.
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• Specificity: Natural and recombinant mouse CHI3L1
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Chil1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Chitinase 3-like 1/YKL-40 Quantikine ELISA Kit

• AW208766
• Brp39
• CHI3L1
• Chitinase 3 like 1
• Chitinase 3-like 1
• gp39
• HCgp39
• YKL-40

Background

Chitinase 3-like 1 (CHI3L1), also called BRP39 in mouse or YKL-40 in humans, is a 39 kDa glycoprotein member of the glycosyl hydrolase 18 family although it does not show chitotriosidase activity. CHI3L1 is expressed by articular chondrocytes, synovial cells, activated monocyte-derived macrophages, neutrophils, endothelial cells, vascular smooth muscle cells, and some cancer cells. CHI3L1 binds to chitin and heparins, and it enhances cell adhesion, proliferation and tumor angiogenesis. Circulating CHI3L1 is elevated during inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. It is frequently upregulated in glioblastoma, myxoid chondrosarcoma, melanoma and carcinomas of the breast, thyroid, colon, lung, kidney, and ovary.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Chitinase 3-like 1/YKL-40 (MC3L10)(8)

Publications using MC3L10

• AZ Johansen, M Carretta, ML Thorseth, S Khan, KY Fjæstad, CB Brøchner, H Linder, C Ankjærgaar, M Donia, I Chen, DL Nielsen, CP Behrens, DH Madsen Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer Oncogene, 2022-05-12;14(5):. 2022-05-12 [PMID: 35631632] (Mouse)
• J Steenbrugg, K Breyne, K Demeyere, O De Wever, NN Sanders, W Van Den Br, C Colpaert, P Vermeulen, S Van Laere, E Meyer Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer J. Exp. Clin. Cancer Res., 2018-08-15;37(1):191. 2018-08-15 [PMID: 30111338] (Mouse)
• Tanaka Y, Matsumoto I, Inoue A, Umeda N, Takai C, Sumida T Antigen-specific over-expression of human cartilage glycoprotein 39 on CD4+ CD25+ forkhead box protein 3+ regulatory T cells in the generation of glucose-6-phosphate isomerase-induced arthritis. Clin Exp Immunol, 2014-08-01;177(2):419-27. 2014-08-01 [PMID: 24730590] (Mouse)
• Yan , Cong, Ding , Xinchun, Wu , Lingyan, Yu , Menggang, Qu , Peng, Du , Hong Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans. PLoS ONE, 2013-04-22;8(4):e61984. 2013-04-22 [PMID: 23613996] (Mouse)
• Xu Q, Chai S, Qian Y, Zhang M, Wang K Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma. Acta Pharmacol Sin, 2012-11-26;33(12):1525-32. 2012-11-26 [PMID: 23178461] (Mouse)
• Louten J, Mattson JD, Malinao MC, Li Y, Emson C, Vega F, Wardle RL, Van Scott MR, Fick RB, McClanahan TK, de Waal Malefyt R, Beaumont M Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma. Biomark Insights, 2012-07-10;7(0):87-104. 2012-07-10 [PMID: 22837640] (Mouse)
• Hector A, Kormann MS, Mack I, Latzin P, Casaulta C, Kieninger E, Zhou Z, Yildirim AÖ, Bohla A, Rieber N, Kappler M, Koller B, Eber E, Eickmeier O, Zielen S, Eickelberg O, Griese M, Mall MA, Hartl D The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease. PLoS ONE, 2011-09-20;6(9):e24399. 2011-09-20 [PMID: 21949714] (Mouse)
• Sakazaki Y, Hoshino T, Takei S Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD. PLoS ONE, 2011-09-07;6(9):e24177. 2011-09-07 [PMID: 21915293] (Mouse)

Bioinformatics

• Gene Symbol: Chil1