Mouse CCL20/MIP-3 alpha Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse CCL20/MIP-3 alpha Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse MIP-3 alpha Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse MIP-3 alpha in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant mouse MIP-3 alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natur...al mouse MIP-3 alpha showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse MIP-3 alpha.
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• Specificity: Natural and recombinant mouse MIP-3 alpha
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ccl20

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL20/MIP-3 alpha Quantikine ELISA Kit

• beta chemokine exodus-1
• Beta-chemokine exodus-1
• CC chemokine LARC
• C-C motif chemokine 20
• CCL20
• chemokine (C-C motif) ligand 20
• CKb4
• exodus-1
• LARC
• LARCLiver and activation-regulated chemokine
• MIP3 alpha
• MIP-3 alpha
• MIP-3a
• MIP-3-alpha
• MIP3AMacrophage inflammatory protein 3 alpha
• SCYA20Small-inducible cytokine A20
• small inducible cytokine subfamily A (Cys-Cys), member 20
• ST38

Background

CCL20, also known as MIP-3 alpha, is a chemokine that plays an important role in dendritic cell trafficking and recruitment and activation of T cells. It is upregulated in monocytes, T cells, endothelial cells, epithelial cells, and fibroblasts following inflammatory stimulation. CCL20 signals through CCR6 which is expressed on memory T cells, B cells and bone marrow-derived dendritic cells.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL20/MIP-3 alpha (MCC200)(18)

Publications using MCC200

• Z Fan, X Zhang, Y Shang, M Zou, M Zhou, Q E, S Fei, W Chen, J Li, X Zhang, X Liu Intestinal Flora Changes Induced by a High-Fat Diet Promote Activation of Primordial Follicles through Macrophage Infiltration and Inflammatory Factor Secretion in Mouse Ovaries International Journal of Molecular Sciences, 2022;23(9):. 2022 [PMID: 35563189] (Mouse)
• K Baker, C O'Donnell, M Bendix, S Keogh, J Byrne, M O'Riordain, P Neary, A Houston, E Brint IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist Oncogene, 2022;0(0):. 2022 [PMID: 35365751] (Mouse)
• M Das, X Tang, JY Han, K Mayilsamy, E Foran, MR Biswal, R Tzekov, SS Mohapatra, S Mohapatra CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies J Neuroinflammation, 2019;16(1):115. 2019 [PMID: 31151410] (Mouse)
• BS Hong, HS Ryu, N Kim, J Kim, E Lee, H Moon, KH Kim, MS Jin, NH Kwon, S Kim, D Kim, DH Chung, K Jeong, K Kim, KY Kim, HB Lee, W Han, J Yun, JI Kim, DY Noh, HG Moon Tumor suppressor microRNA-204-5p regulates growth, metastasis, and immune microenvironment remodeling in breast cancer Cancer Res., 2019;0(0):. 2019 [PMID: 30737233] (Mouse)
• CM Wunderlich, PJ Ackermann, AL Ostermann, P Adams-Quac, MC Vogt, ML Tran, A Nikolajev, A Waisman, C Garbers, S Theurich, J Mauer, N Hövelmeyer, FT Wunderlich Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment Nat Commun, 2018;9(1):1646. 2018 [PMID: 29695802] (Mouse)
• N Hernández-, DL Wiesner, JS Fites, AJ McDermott, T Warner, M Wüthrich, BS Klein Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection Cell Host Microbe, 2018;0(0):. 2018 [PMID: 29576482] (Mouse)
• Carroll J, Striebel J, Race B, Phillips K, Chesebro B Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction. J Virol, 2015;89(4):2388-404. 2015 [PMID: 25505076] (Mouse)
• Klein M, Brouwer M, Angele B, Geldhoff M, Marquez G, Varona R, Hacker G, Schmetzer H, Hacker H, Hammerschmidt S, van der Ende A, Pfister H, van de Beek D, Koedel U Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis. PLoS ONE, 2014;9(4):e93057. 2014 [PMID: 24699535] (Mouse)
• Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert R, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee J, Fujihashi K Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS ONE, 2013;8(4):e60453. 2013 [PMID: 23565250] (Mouse)
• Provoost S, Maes T, Joos GF, Tournoy KG Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent. J. Allergy Clin. Immunol., 2012;129(2):483-91. 2012 [PMID: 21906792] (Mouse)
• Li Z, Burns AR, Miller SB, Smith CW CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing. FASEB J., 2011;25(8):2659-68. 2011 [PMID: 21518851] (Mouse)
• Demoor T, Bracke KR, Dupont LL The Role of ChemR23 in the Induction and Resolution of Cigarette Smoke-Induced Inflammation. J. Immunol., 2011;186(9):5457-67. 2011 [PMID: 21430224] (Mouse)
• Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J. Clin. Invest., 2010;120(5):1645-62. 2010 [PMID: 20389019] (Mouse)
• Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis. J. Invest. Dermatol., 2009;129(0):2175. 2009 [PMID: 19295614] (Mouse)
• Cho YS, Oh SY, Zhu Z Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation. Am. J. Respir. Cell Mol. Biol., 2008;39(4):412-9. 2008 [PMID: 18441283] (Mouse)
• Bartlett NW, Walton RP, Edwards MR, Aniscenko J, Caramori G, Zhu J, Glanville N, Choy KJ, Jourdan P, Burnet J, Tuthill TJ, Pedrick MS, Hurle MJ, Plumpton C, Sharp NA, Bussell JN, Swallow DM, Schwarze J, Guy B, Almond JW, Jeffery PK, Lloyd CM, Papi A, Killington RA, Rowlands DJ, Blair ED, Clarke NJ, Johnston SL Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat. Med., 2008;14(2):199-204. 2008 [PMID: 18246079] (Mouse)
• Robays LJ, Maes T, Lebecque S, Lira SA, Kuziel WA, Brusselle GG, Joos GF, Vermaelen KV Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation. J. Immunol., 2007;178(8):5305-11. 2007 [PMID: 17404315] (Mouse)
• Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med., 2006;203(12):2763-77. 2006 [PMID: 17116732] (Mouse)

Bioinformatics

• Gene Symbol: Ccl20