MMR/CD206/Mannose Receptor Antibody [Unconjugated]

Western blot shows lysates of human immature dendritic cells. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2534) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for MMR/CD206 at approximately 185 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

MMR/CD206 was detected in immersion fixed paraffin-embedded sections of human liver using Goat Anti-Human MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2534) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to sinusoids. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western lane view shows lysates of human immature dendritic cells, loaded at 0.2 mg/mL. A specific band was detected for MMR/CD206 at approximately 201 kDa (as indicated) using 10 µg/mL of Goat Anti-Human MMR/CD206 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2534) . This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Osteopontin is overexpressed in human MPM patients. (A) Real Time PCR for the Spp1 gene (osteopontin, OPN) in surgical human MPM samples. Comparison between tumor and undiseased adjacent tissues. Data are shown as mean ± SEM (Unpaired t test with Welch’s correction). (B) ELISA quantification of hOPN on plasma samples from 99 MPM patients and 101 healthy subjects. (ROUT, identify outlier and Unpaired t test with Welch’s correction). (C) Kaplan-Meier curves of overall survival according to OPN levels categorized based on CART analysis cut-off (n=61 MPM patients). (D–F) Representative images of immunohistochemistry in MPM tumor tissues stained for OPN or CD206 (40x, insert 100x) and semi-quantitative analysis in 28 cases (0=negative, 1 = 1-25% positivity, 2 = 26-50% positivity, 3= >50% positivity). Data are shown as mean ± SEM. (Unpaired t test with Welch’s correction). (G, H) ELISA quantification of hOPN on plasma samples from 18 MPM patients treated with immunotherapy. Blood was collected at baseline and after revalutation at 4-6 months. Patients with progressive disease (PD): 6 patients; stable disease (SD): 6 patients; partial response (PR): 6 patients. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/37398648), licensed under a CC-BY license. Not internally tested by R&D Systems.

Cisplatin does not affect TAM viability and M2 phenotype. (A) IHC analysis of CD68, stabilin-1 and CD206 expression in human breast cancer tissue treated and not treated with cisplatin-based therapy. (B) Quantitative analysis of CD68, stabilin-1 and CD206 expression. Tumor tissue was obtained after surgery for all patients. (C) Schematic description of ex vivo TAM generation which were stimulated with MCF-7 supernatants and treated by cisplatin. (D) Immunofluorescent staining/confocal microscopy of CD206 and stabilin-1 expression in CD68+ ex vivo TAMs. Scale bars are equal to 11µM. (E) Viability assay for ex vivo TAMs treated with cisplatin. Viability was estimated on day 6 before cisplatin treatment and day 9 after cisplatin-treatment (n=6 independent experiments). Data information: In (B), the level of protein expression is presented as Me (Q1;Q3). In (E), OD means defined in the percentage of NS control are presented as mean ± SD. The Manna-Whitney test was applied to compare two independent groups. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/36960065), licensed under a CC-BY license. Not internally tested by R&D Systems.

Cisplatin does not affect TAM viability and M2 phenotype. (A) IHC analysis of CD68, stabilin-1 and CD206 expression in human breast cancer tissue treated and not treated with cisplatin-based therapy. (B) Quantitative analysis of CD68, stabilin-1 and CD206 expression. Tumor tissue was obtained after surgery for all patients. (C) Schematic description of ex vivo TAM generation which were stimulated with MCF-7 supernatants and treated by cisplatin. (D) Immunofluorescent staining/confocal microscopy of CD206 and stabilin-1 expression in CD68+ ex vivo TAMs. Scale bars are equal to 11µM. (E) Viability assay for ex vivo TAMs treated with cisplatin. Viability was estimated on day 6 before cisplatin treatment and day 9 after cisplatin-treatment (n=6 independent experiments). Data information: In (B), the level of protein expression is presented as Me (Q1;Q3). In (E), OD means defined in the percentage of NS control are presented as mean ± SD. The Manna-Whitney test was applied to compare two independent groups. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/36960065), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Hu
• Applications: WB, Simple Western, IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

MMR/CD206/Mannose Receptor Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human MMR/CD206
  Leu19-Lys1383 (Thr399Ala) & (Leu407Phe)
  Accession # P22897
• Specificity: Detects human MMR/CD206 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse MMR is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MRC1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry 5-15 ug/mL
  • Immunohistochemistry 3-15 ug/mL
  • Simple Western 10 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MMR/CD206/Mannose Receptor Antibody [Unconjugated]

• CD206
• CLEC13D
• CLEC13Dmacrophage mannose receptor 1
• C-type lectin domain family 13 member D
• mannose receptor, C type 1
• MMR
• MMRCD206 antigen
• MRC1

Background

The human Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 190 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells (1). It belongs to a family of receptors sharing similar protein structure that also includes DEC205, phospholipase A2 receptor, and Endo180 (2, 3). The human MMR protein is synthesized as a 1456 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1371 aa extracellular region, a 21 aa transmembrane segment and a 46 aa cytoplasmic domain (4). Its extracellular region is composed of an N-terminal cysteine-rich domain, followed by a single fibronectin type II repeat, and eight C-type lectin carbohydrate recognition domains (CRD) (3, 4). Human to mouse, the extracellular region is 82% aa identical. The cysteine-rich domain mediates recognition of sulfated N-acetylgalactosamine, which occurs on some extracellular matrix proteins and is the terminal sugar of the unusual oligosaccharides present on pituitary hormones such as lutropin and thyrotropin (5). Several of the CRDs participate in the Ca2 + -dependent recognition of carbohydrates showing a preference for branched sugars with terminal mannose, fucose or N-acetylglucosamine (6). The cytoplasmic domain of MMR includes a tyrosine-based motif for internalization in clathrin-coated vesicles. Once internalized, ligands are released following acidification of phagosomes or endosomes, and the receptor is recycled to the cell surface (3, 7). MMR mediates phagocytosis upon binding to target structures that occur on a variety of pathogenic microorganisms including Gram-negative and Gram-positive bacteria, yeasts, parasites, and mycobacteria. MMR also functions to maintain homeostasis through the endocytosis of potentially harmful glycoproteins associated with inflammation (2, 3).

1. East, L. and C. Isake (2002) Biochim. Biophys. Acta 1572:364. 
2. Chieppa, M. et al. (2003) J. Immunol. 171:4552. 
3. Figdor, C. et al. (2002) Nat. Rev. Immunol. 2:77.
4. Taylor, M. et al. (1990) J. Biol. Chem. 265:12156.
5. Leteux, C. et al. (2000) J. Exp. Med. 191:1117.
6. Martinez-Pomares, L. et al. (2001) Immunobiology 204:527.
7. Feinberg, H. et al. (2000) J. Biol. Chem. 275:21539.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MMR/CD206/Mannose Receptor Antibody (AF2534)(43)

Publications using AF2534

• Belgiovine, C;Digifico, E;Erreni, M;Putignano, AR;Mannarino, L;Valentino, S;Grizzi, F;Pasqualini, F;Recordati, C;Bertola, L;Zucali, P;Pistillo, D;Paleari, V;Mantovani, A;D'Incalci, M;Marchesi, F;Allavena, P; Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB Journal of translational medicine 2025-04-18 [PMID: 40251684] (Immunohistochemistry, Human)
• Dos Santos, JC;Moreno, M;Teufel, LU;Chilibroste, S;Keating, ST;Groh, L;Domínguez-Andrés, J;Williams, DL;Ma, Z;Lowman, DW;Ensley, HE;Novakovic, B;Ribeiro-Dias, F;Netea, MG;Chabalgoity, JA;Joosten, LAB; Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity Cell reports 2024-03-07 [PMID: 38457336] (Functional Assay, Human)
• Ma, Q;Chang, Y;Liu, J;Jiang, Y;Ma, A;Yeo, YY;Guo, Q;McNutt, M;Krull, J;Rodig, S;Barouch, D;Nolan, G;Xu, D;Jiang, S;Li, Z;Liu, B; Graph Fourier transform for spatial omics representation and analyses of complex organs Research square 2024-02-15 [PMID: 38410424] (Flow Cytometry, Human)
• Antwi, MB;Dumitriu, G;Simón-Santamaria, J;Romano, JS;Li, R;Smedsrød, B;Vik, A;Eskild, W;Sørensen, KK; Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmpgt/gt mouse model of slowly progressing liver fibrosis PloS one 2023-11-01 [PMID: 37910485] (IHC, Western Blot, Transgenic Mouse, Mouse)
• Elisabeth Digifico, Marco Erreni, Laura Mannarino, Sergio Marchini, Aldo Ummarino, Clément Anfray et al. Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma Frontiers in Immunology 2023-06-16 [PMID: 37398648] (Immunohistochemistry, Human)
• Elisabeth Digifico, Marco Erreni, Laura Mannarino, Sergio Marchini, Aldo Ummarino, Clément Anfray et al. Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma Frontiers in Immunology 6/16/2023 [PMID: 37398648]
• KW Southerlan, Y Xu, DT Peters, X Wei, X Lin, Y Xiang, K Fei, LA Olivere, JM Morowitz, J Otto, Q Dai, CD Kontos, Y Diao Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066299] (IHC, Human)
• Larionova I, Kiselev A, Kazakova E et al. Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF Frontiers in immunology 3/7/2023 [PMID: 36960065]
  
  Details:
  Dilution used in IHC-P 1:100
• Y Heng, X Zhu, H Lin, M Jingyu, X Ding, L Tao, L Lu CD206+ tumor-associated macrophages interact with CD4+ tumor-infiltrating lymphocytes and predict adverse patient outcome in human laryngeal squamous cell carcinoma Journal of Translational Medicine, 2023-03-03;21(1):167. 2023-03-03 [PMID: 36864443] (IHC, Human)
• Mustafa Yilmaz, Esra Demir, Yigit Firatli, Erhan Firatli, Ulvi Kahraman Gürsoy Tissue Levels of CD80, CD163 and CD206 and Their Ratios in Periodontal and Peri-Implant Health and Disease Current Issues in Molecular Biology 10/10/2022 [PMID: 36286036]
• Satoshi Horiba, Ryota Kami, Taiki Tsutsui, Junichi Hosoi IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin JID Innovations 5/1/2022 [PMID: 35521044]
• Gang Li, Xin Li, Li Yang, Shuyue Wang, Yulin Dai, Baharan Fekry et al. Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice Life Science Alliance 8/1/2022 [PMID: 35459739]
• P Madden, Y Thomas, R Blair, S Samer, M Doyle, C Midkiff, L Doyle-Meye, M Becker, S Arif, M McRaven, L Simons, A Carias, E Martinelli, R Lorenzo-Re, J Hultquist, F Villinger, R Veazey, T Hope An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques Research square, 2022-04-08;0(0):. 2022-04-08 [PMID: 35411346] (Immunohistochemistry, Primate - Macaca mulatta (Rhesus Macaque))
• Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral et al. PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells Journal for ImmunoTherapy of Cancer 1/24/2022 [PMID: 35078921]
• Anett Kristin Larsen, Jaione Simón-Santamaría, Kjetil Elvevold, Bo Göran Ericzon, Kim Erlend Mortensen, Peter McCourt et al. Autofluorescence in freshly isolated adult human liver sinusoidal cells European Journal of Histochemistry 12/13/2021 [PMID: 34897295]
• BS Finlin, H Memetimin, AL Confides, B Zhu, PM Westgate, EE Dupont-Ver, PA Kern Macrophages expressing uncoupling protein 1 increase in adipose tissue in response to cold in humans Scientific Reports, 2021-12-08;11(1):23598. 2021-12-08 [PMID: 34880313] (IHC, Human)
• M Dymowska, A Aksamit, K Zielniok, M Kniotek, B Kaleta, A Roszczyk, M Zych, F Dabrowski, L Paczek, A Burdzinska Interaction between Macrophages and Human Mesenchymal Stromal Cells Derived from Bone Marrow and Wharton's Jelly-A Comparative Study Pharmaceutics, 2021-11-01;13(11):. 2021-11-01 [PMID: 34834238] (ICC, Human)
• Z Gao, A Lu, AC Daquinag, Y Yu, M Huard, C Tseng, X Gao, J Huard, MG Kolonin Partial Ablation of Non-Myogenic Progenitor Cells as a Therapeutic Approach to Duchenne Muscular Dystrophy Biomolecules, 2021-10-15;11(10):. 2021-10-15 [PMID: 34680151] (IHC, Mouse)
• Fang Y, Jiang Q, Li S et al. Opposing functions of ?-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3 Cell Death & Differentiation 6/1/2021 [PMID: 33686256]
• Fang Y, Jiang Q, Li S et al. Opposing functions of ?-arrestin 1 and 2 in Parkinson's disease via microglia inflammation and Nprl3 Cell Death & Differentiation 2021-06-01 [PMID: 33686256]
• Bhandari, S, Li, R Et al. Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages. BMC Mol Cell Biol 11/27/2020 [PMID: 33246411]
• S Taylor, M Whitfield, J Barratt, A Didangelos The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix J. Immunol., 2020-09-11;0(0):. 2020-09-11 [PMID: 32917786] (IHC, Human)
• K Kosmac, M Gonzalez-F, MM McDermott, SH White, RG Walton, RL Sufit, L Tian, L Li, MR Kibbe, MH Criqui, JM Guralnik, T S Polonsky, C Leeuwenbur, L Ferrucci, CA Peterson Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease J Am Heart Assoc, 2020-05-09;9(10):e015929. 2020-05-09 [PMID: 32390569] (IHC, Human)
• Michael J. Podolsky, Christopher D. Yang, Carlos Lizama Valenzuela, Ritwik Datta, Steven K. Huang, Stephen L. Nishimura et al. Age-dependent regulation of cell-mediated collagen turnover JCI Insight 5/21/2020 [PMID: 32315288]
• Kasper Yde Jensen, Mikkel Jacobsen, Henrik Daa Schrøder, Per Aagaard, Jakob Lindberg Nielsen, Anders Nørkær Jørgensen et al. The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training Arthritis Research & Therapy 12/18/2019 [PMID: 31852482]
• CY Cui, RK Driscoll, Y Piao, CW Chia, M Gorospe, L Ferrucci Skewed macrophage polarization in aging skeletal muscle Aging Cell, 2019-09-02;0(0):e13032. 2019-09-02 [PMID: 31478346] (IHC-Fr, Human)
• Greet De Vlieger, Ilse Vanhorebeek, Pieter J. Wouters, Inge Derese, Michael P. Casaer, Yves Debaveye et al. The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT Critical Care 12/1/2019 [PMID: 31375142]
• B Liu, AT Hutchison, CH Thompson, K Lange, LK Heilbronn Markers of adipose tissue inflammation are transiently elevated during intermittent fasting in women who are overweight or obese Obes Res Clin Pract, 2019-07-11;0(0):. 2019-07-11 [PMID: 31302012] (IHC-P, Human)
• MC Nielsen, MN Andersen, N Rittig, S Rødgaard-H, H Grønbaek, SK Moestrup, HJ Møller, A Etzerodt The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms J. Leukoc. Biol., 2019-06-26;0(0):. 2019-06-26 [PMID: 31242338] (ELISA Capture, Human)
• Carlos Garaicoa‐Pazmino, Tobias Fretwurst, Cristiane H. Squarize, Tord Berglundh, William V. Giannobile, Lena Larsson et al. Characterization of macrophage polarization in periodontal disease Journal of Clinical Periodontology 8/1/2019 [PMID: 31152604]
• T Zhang, L Liu, W Lai, Y Zeng, H Xu, Q Lan, P Su, Z Chu Interaction with tumor?associated macrophages promotes PRL?3?induced invasion of colorectal cancer cells via MAPK pathway?induced EMT and NF??B signaling?induced angiogenesis Oncol. Rep., 2019-03-07;0(0):. 2019-03-07 [PMID: 30864736] (Flow Cytometry, Human)
• Matthew K. Abramowitz, William Paredes, Kehao Zhang, Camille R. Brightwell, Julia N. Newsom, Hyok-Joon Kwon et al. Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease American Journal of Physiology-Renal Physiology 12/1/2018 [PMID: 30280599]
• Matthew K. Abramowitz, William Paredes, Kehao Zhang, Camille R. Brightwell, Julia N. Newsom, Hyok-Joon Kwon et al. Skeletal muscle fibrosis is associated with decreased muscle inflammation and weakness in patients with chronic kidney disease American Journal of Physiology-Renal Physiology 2018-12-01 [PMID: 30280599] (Immunohistochemistry, Human)
• Kate Kosmac, Bailey D. Peck, R. Grace Walton, Jyothi Mula, Philip A. Kern, Marcas M. Bamman et al. Immunohistochemical Identification of Human Skeletal Muscle Macrophages BIO-PROTOCOL 6/20/2018 [PMID: 30148186]
• R Yang, M Wu, S Lin, RP Nargund, X Li, T Kelly, L Yan, G Dai, Y Qian, Q Dallas-Yan, PA Fischer, Y Cui, X Shen, P Huo, DD Feng, MD Erion, DE Kelley, J Mu A glucose-responsive insulin therapy protects animals against hypoglycemia JCI Insight, 2018-01-11;3(1):. 2018-01-11 [PMID: 29321379] (Bioassay)
• YF Malada-Ede, N Hadad, R Levy Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia J Neuroinflammation, 2017-02-10;14(1):33. 2017-02-10 [PMID: 28187742] (IHC, Mouse)
• FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides PLoS ONE, 2016-08-05;11(8):e0160602. 2016-08-05 [PMID: 27494406] (IHC, Human, Mouse)
• Millar N, Gilchrist D, Akbar M, Reilly J, Kerr S, Campbell A, Murrell G, Liew F, Kurowska-Stolarska M, McInnes I MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nat Commun, 2015-04-10;6(0):6774. 2015-04-10 [PMID: 25857925] (IHC, Human, Mouse)
• Jaione Simon-Santamaria, Christine Hanssen Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, Kjetil Elvevold et al. Efficient Uptake of Blood-Borne BK and JC Polyomavirus-Like Particles in Endothelial Cells of Liver Sinusoids and Renal Vasa Recta PLoS ONE 11/6/2014 [PMID: 25375646]
• Jaione Simon-Santamaria, Christine Hanssen Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, Kjetil Elvevold et al. Efficient Uptake of Blood-Borne BK and JC Polyomavirus-Like Particles in Endothelial Cells of Liver Sinusoids and Renal Vasa Recta PLoS ONE 2014-11-06 [PMID: 25375646] (Immunohistochemistry, Mouse)
• Spencer M, Yang L, Adu A, Finlin B, Zhu B, Shipp L, Rasouli N, Peterson C, Kern P Pioglitazone treatment reduces adipose tissue inflammation through reduction of mast cell and macrophage number and by improving vascularity. PLoS ONE, 2014-07-10;9(7):e102190. 2014-07-10 [PMID: 25010722] (IHC-P, Human)
• Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L, De Palma M Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell, 2011-04-12;19(4):512-26. 2011-04-12 [PMID: 21481792] (IHC, Mouse)
• Kuo HS, Tsai MJ, Huang MC Acid fibroblast growth factor and peripheral nerve grafts regulate Th2 cytokine expression, macrophage activation, polyamine synthesis, and neurotrophin expression in transected rat spinal cords. J. Neurosci., 2011-03-16;31(11):4137-47. 2011-03-16 [PMID: 21411654] (IHC, Rat)

Reviews for MMR/CD206/Mannose Receptor Antibody (AF2534) (3)

Average Rating: 4

(Based on 3 reviews)

We have 3 reviews tested in 1 species: Human.

reviewed by: Verified Customer Immunofluorescence - paraffin Human 04/12/2019

Summary

• Application: Other
• Sample Tested: Human spleen, FFPE
• Species: Human
• Lot: I don't have it any more

Comments

• Comments: pH9 antigen retrieval

reviewed by: Verified Customer IF Human 01/07/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 22516068
• Species: Human

reviewed by: Verified Customer IF Human 01/07/2015

Summary

• Application: Immunofluorescence
• Sample Tested: See PMID 22500753
• Species: Human

Bioinformatics

• Gene Symbol: MRC1
• Uniprot:
  • P22897()