MMR/CD206/Mannose Receptor Products

Antibodies
MMR/CD206/Mannose Receptor An ...
MMR/CD206/Mannose Receptor Antibod...
AF2535
Species: Mu
Applications: WB, Flow, IHC
Host: Goat Polyclonal
MMR/CD206/Mannose Receptor An ...
MMR/CD206/Mannose Receptor Antibod...
H00004360-M02
Species: Hu, Fu
Applications: WB, ELISA, IHC, IHC-P
Host: Mouse Monoclonal
MMR/CD206/Mannose Receptor An ...
MMR/CD206/Mannose Receptor Antibod...
AF2534
Species: Hu
Applications: WB, ICC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Proteins
MMR/CD206/Mannose Receptor Pa ...
MMR/CD206/Mannose Receptor Partial...
H00004360-Q01
Species: Hu
Applications: WB, ELISA, PA
MMR/CD206/Mannose Receptor Re ...
MMR/CD206/Mannose Receptor Recombi...
NBP2-52927PEP
Species: Hu
Applications: AC
MMR/CD206/Mannose Receptor Re ...
MMR/CD206/Mannose Receptor Recombi...
NBP1-90020PEP
Species: Hu
Applications: AC
RNAi
MMR/CD206/Mannose Receptor RN ...
MMR/CD206/Mannose Receptor RNAi
H00414308-R02
Species: Hu
Applications: RNAi, RNAi SP
MMR/CD206/Mannose Receptor RN ...
MMR/CD206/Mannose Receptor RNAi
H00004360-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.

Bioinformatics

Entrez Human
Human
Uniprot Human
Human
Product By Gene ID 4360
Alternate Names
  • CD206
  • MMRCD206 antigen
  • CLEC13Dmacrophage mannose receptor 1
  • C-type lectin domain family 13 member D
  • mannose receptor, C type 1

Research Areas for MMR/CD206/Mannose Receptor

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Signal Transduction

PTMs for MMR/CD206/Mannose Receptor

Learn more about PTMs related to MMR/CD206/Mannose Receptor.

Phosphorylation
Acetylation
Sumoylation
Reduction
Deacetylation
Ubiquitination

Bioinformatics Tool for MMR/CD206/Mannose Receptor

Discover related pathways, diseases and genes to MMR/CD206/Mannose Receptor. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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