MMP-15/MT2-MMP Antibody (MM0028-5D11)

Images

 
Immunohistochemistry-Paraffin: MMP15 Antibody (MM0028-5D11) [NB110-60994] - Human placenta (formalin fixed and paraffin embedded) section is subjected to IHC.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
MM0028-5D11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

MMP-15/MT2-MMP Antibody (MM0028-5D11) Summary

Immunogen
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified recombinant human matrix metalloproteinase-15.
Specificity
MMP15 (MM0028-5D11)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
MMP15
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:400-1:1000
  • Immunohistochemistry 1:50-200
  • Immunohistochemistry-Paraffin 1:50-200
Application Notes
This antibody recognizes human MMP-15 in western blot without cross reactivity with human MMP-14/16.
Control
MMP-15/MT2-MMP Overexpression Lysate

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Lyophilized from 0.2 um filtered PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein G purified
Reconstitution Instructions
Reconstitute with sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for MMP-15/MT2-MMP Antibody (MM0028-5D11)

  • EC 3.4.24
  • EC 3.4.24.-
  • EC 3.4.24.80
  • matrix metallopeptidase 15 (membrane-inserted)
  • matrix metalloproteinase 15 (membrane-inserted)
  • Membrane-type matrix metalloproteinase 2
  • Membrane-type-2 matrix metalloproteinase
  • MMP15
  • MMP-15
  • MT2-MMP
  • MT2-MMPMT2MMP
  • MTMMP2MT-MMP 2
  • SMCP-2matrix metalloproteinase-15

Background

The mammalian matrix metalloproteinases (MMPs) degrade extracellular matrix in physiological and pathological processes. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT MMPs exist as integral membrane proteins. MMP15, first described as MTMMP2, is a metalloproteinase with a type I transmembrane domain. Initially reported in lung tissue, MMP15 message was also seen in testis, intestines, colon, heart, liver, kidney, pancreas and muscle. Western blots showed bands at 72 kD, 48 kD and 44 kD. Subsequent publications have focused on message, and found MMP15 in a wide range of tumor cell lines, as well as the synovial membrane from patients with rheumatoid arthritis. MMP15 is usually found in much lower levels than the more ubiquitous MMP14 (MT1MMP). MMP15 may be shed into the culture media when activated, but it is unclear if the shed form is proteolytically active. Cell lysates are the best source for Western blotting of MMP15.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for MMP-15/MT2-MMP Antibody (NB110-60994) (0)

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NB110-60994AF350
Alexa Fluor 405 NB110-60994AF405
Alexa Fluor 488 NB110-60994AF488
Alexa Fluor 532 NB110-60994AF532
Alexa Fluor 594 NB110-60994AF594
Alexa Fluor 647 NB110-60994AF647
Alexa Fluor 700 NB110-60994AF700
Alexa Fluor 750 NB110-60994AF750
Biotin NB110-60994B
DyLight 350 NB110-60994UV
DyLight 405 NB110-60994V
DyLight 488 NB110-60994G
DyLight 550 NB110-60994R
DyLight 594 NB110-60994DL594
DyLight 650 NB110-60994C
DyLight 680 NB110-60994FR
DyLight 755 NB110-60994IR
FITC NB110-60994F
HRP NB110-60994H
Janelia Fluor 549 NB110-60994JF549
Janelia Fluor 646 NB110-60994JF646

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Bioinformatics Tool for MMP-15/MT2-MMP Antibody (NB110-60994)

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Diseases for MMP-15/MT2-MMP Antibody (NB110-60994)

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Research Areas for MMP-15/MT2-MMP Antibody (NB110-60994)

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Contact Information

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Bioinformatics

Gene Symbol MMP15
Entrez