Mineralocorticoid R/NR3C2 Antibody (H3122) [Unconjugated]

• Reactivity: Hu
• Applications: WB, IHC, IP, ELISA
• Clone: H3122
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Suitable Sample Type: 23015

Mineralocorticoid R/NR3C2 Antibody (H3122) [Unconjugated] Summary

• Immunogen: Recombinant human Mineralocorticoid R/NR3C2
  aa 2-99
• Specificity: This antibody specifically recognizes human MR and cross-reacts with mouse and rat MR. Not yet tested in other species.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: NR3C2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
  • Direct ELISA

Packaging, Storage & Formulations

• Storage: This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
• Buffer: A liquid formulation in physiologic saline with 0.1% NaN₃.
• Preservative: 0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mineralocorticoid R/NR3C2 Antibody (H3122) [Unconjugated]

• FLJ41052
• MGC133092
• Mineralocorticoid R
• mineralocorticoid receptor 1
• mineralocorticoid receptor delta
• MineralocorticoidR
• MLR
• MLRmineralocorticoid receptor
• MRMCRaldosterone receptor
• NR3C2
• NR3C2VIT
• Nuclear receptor subfamily 3 group C member 2
• nuclear receptor subfamily 3, group C, member 2

Background

Mineralcorticoid Receptor (MR; NR3C2) is a member of the Steroid Receptor superfamily (AR,ER,GR,PR). Aldosterone binds to MR with a high affinity. MR is expressed in the kidney, gut, brain, pituitary, hypothalamus and heart. MR plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system. The protein is expressed as a 107 kDa nuclear form. MR and GR can cooperatively form heterodimers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NR3C2