Based on sequence similarity this antibody is expected to react with Sheep, Pig, and Horse. Mouse reactivity reported in a scientific publication (PMID: 23570453). Rat reactivity reported in a scientific publication (PMID: 23800500).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.09% Sodium Azide
Protein A or G purified
Alternate Names for Angiotensin II/III Antibody (Ang II E7 (BGN/KA/4L))
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Angiotensin is a polypeptide vasopressor hormone formed by the catalytic action of renin, which is released mainly by the kidneys in response to low blood volume or low sodium content in the body. The juxtaglomerular cells release renin when juxtaglomerular apparatus decreases in the kidneys. Renin (called angiotensinogenase) is an enzyme of the hydrolase class that catalyzes cleavage of the leucine leucine bond in angiotensinogen (a serum globulin) to generate angiotensin I in the liver. Angiotensin I acts mainly as a precursor to angiotensin II, which is a vasopressor and stimulator of aldosterone secretion by the adrenal cortex, and functions also as a neurotransmitter. Angiotensin II is formed by catalytic action of the hydrolase called peptidyl dipeptidase A on C terminal oligopeptide (angiotensin I). In case of the cleavage of angiotensin I to the activated angiotensin II, it is called angiotensin converting enzyme (ACE); in case of the cleavage and inactivation of kinins, it is called kininase II (also called dipeptidyl carboxypeptidase I). The renin-angiotensin system plays an important role in the regulation of blood volume and blood pressure, stimulates antidiuretic hormone and aldosterone production, and the hypothalamus to activate the thirst reflex, but is crucial in the pathogenesis of hypertension patients due to blood vessels constrict, retention of fluid and raising blood pressure.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Angiotensin II/III Antibody (NB100-62346). (Showing 1 - 1 of 1 FAQs).
According to the product datasheet, NB100-62346 indicates Angiotensin II/III antibody. However, the Angiotensin II protein (http://www.novusbio.com/Serpin-A8-Angiotensinogen-Protein_NBP1-99199.html.) which you recommand to use to do the preabsorption test is Serpin A8/Angiotensinogen partial recombinant protein (38 kDa). Which one was used to produce Angiotensin II/III antibody (NB100-62346), angiotensin II or angiotensinogen partial recombinant protein ?
Product NB100-62346 was made to the angiotensin II protein (aa34-41), which is a partial recombinant protein of the angiotensinogen full length protein (aa 1-485). You can use protein NBP1-99199 to perform a pre-absorption test since it is the same amino acids as the antigen used to make NB100-62346.
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