MICA/B Antibody (159207) [Unconjugated]

Images

 
MICA/B was detected in immersion fixed paraffin-embedded sections of human pancreas using Mouse Anti-Human MICA/B Monoclonal Antibody (Catalog # MAB13001) at 15 µg/mL overnight at 4 °C. Before incubation with the ...read more
K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human MICA/B Monoclonal Antibody (Catalog # MAB13001, filled histogram) or isotype control antibody (Catalog # MAB003, open ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, B/N, CyTOF-ready
Clone
159207
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

MICA/B Antibody (159207) [Unconjugated] Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human MICA
Accession # Q29983
Specificity
Detects human MICA/B in direct ELISAs.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
MICA
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Blockade of Receptor-ligand Interaction
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publications using
MAB13001 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MICA/B Antibody (159207) [Unconjugated]

  • MHC class I chain-related protein A
  • MHC class I chain-related protein B
  • MIC
  • MICA
  • MICA/B
  • MICB
  • PERB11
  • PERB11.1
  • PERB11.2

Background

MICA and MICB are stress-induced type I transmembrane proteins that function as ligands for NKG2D. They are distantly related to MHC class I proteins and are expressed on epithelial tumors and in response to infections.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MICA/B Antibody (MAB13001)(8)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: Flow Cytometry, ICC, IHC, Immunoprecipitation, Western Blot.


Filter By Application
Flow Cytometry
(3)
ICC
(1)
IHC
(1)
Immunoprecipitation
(1)
Western Blot
(2)
All Applications
Filter By Species
Human
(8)
All Species
Showing Publications 1 - 8 of 8.
Publications using MAB13001 Applications Species
CF Huang, SC Wang, WT Chang, ML Yeh, CI Huang, ZY Lin, SC Chen, WL Chuang, JF Huang, CY Dai, YL Chen, ML Yu Lower protein expression levels of MHC class I chain-related gene A in hepatocellular carcinoma are at high risk of recurrence after surgical resection Sci Rep, 2018;8(1):15821. 2018 [PMID: 30361527] (IHC, Human) IHC Human
Cox S, Laza-Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, Madrigal J, Saudemont A Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol, 2015;45(8):2324-34. 2015 [PMID: 25991034] (Immunoprecipitation, Human) Immunoprecipitation Human
Kim H, Bose S, Meyer K, Ray R Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis. J Virol, 2014;88(5):2564-71. 2014 [PMID: 24352446] (Western Blot, Human) Western Blot Human
Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012;8(1):e1002486. 2012 [PMID: 22253598] (Flow Cytometry, Human) Flow Cytometry Human
Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva-Nilsson L Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells. PLoS ONE, 2011;6(2):e16899. 2011 [PMID: 21364924] (Western Blot, Human) Western Blot Human
Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma. Oncogene, 2011;30(23):2622-32. 2011 [PMID: 21258414] (Flow Cytometry, Human) Flow Cytometry Human
Roda-Navarro P, Vales-Gomez M, Chisholm SE, Reyburn HT Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc. Natl. Acad. Sci. U.S.A., 2006;103(30):11258-63. 2006 [PMID: 16849432] (ICC, Human) ICC Human
Skov S, Pedersen MT, Andresen L, Straten PT, Woetmann A, Odum N Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. Cancer Res., 2005;65(23):11136-45. 2005 [PMID: 16322264] (Flow Cytometry, Human) Flow Cytometry Human

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol MICA
Uniprot