MICA/B Products


Description

The MIC gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate beta2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN- alpha-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/ beta T cells and gamma/ delta T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases.

Bioinformatics

Entrez Human
Human
Human
Uniprot Human
Human
Product By Gene ID 100507436
Alternate Names
  • MHC class I chain-related protein A
  • PERB11.2
  • PERB11.1
  • PERB11
  • MICB
  • MICA
  • MIC
  • MHC class I chain-related protein B

Diseases related to MICA/B

Discover more about diseases related to MICA/B.

Pica Disease
Anemia
Hemochromatosis
Hypoxia
Microcytic Anemia
Cerebrovascular Disorders

Pathways for MICA/B

View related products by pathway and learn more about each of the pathways below.

Transport
Proteolysis
Secretion

Bioinformatics Tool for MICA/B

Discover related pathways, diseases and genes to MICA/B. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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