Flow, IHC, Block, CyTOF-readyHost:
The MIC gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate beta2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN- alpha-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/ beta T cells and gamma/ delta T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases.
|Product By Gene ID
- MHC class I chain-related protein A
- MHC class I chain-related protein B
Bioinformatics Tool for MICA/B
Discover related pathways, diseases and genes to MICA/B. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.