MICA/B Products

Description

The MIC gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate beta2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN- alpha-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/ beta T cells and gamma/ delta T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases.

Bioinformatics

Entrez	100507436 Human 4276 Human 4277 Human
Uniprot	Q29980 Human Q29983 Human
Product By Gene ID	100507436
Alternate Names	MHC class I chain-related protein A MHC class I chain-related protein B MIC MICA MICB PERB11 PERB11.1 PERB11.2