Melanocortin-4 R Antibody

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Melanocortin-4 R Antibody Summary

• Immunogen: Peptide with sequence NSTHRGMHTSLH-C corresponding to N-Terminus according to NP_005903.2.
• Specificity: The immunizing peptide represents extracellular part of the protein
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MC4R
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
  • Western Blot 1:100 - 1:2000
• Application Notes: WB: Preliminary experiments in human brain, colon, duodenum, Ileum and placenta lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Melanocortin-4 R Antibody

• Fatboy
• Glu3
• MC4R
• MC4-R
• melanocortin 4 receptor
• melanocortin receptor 4
• Melanocortin-4 R
• Melanocortin4R
• Melanocortin-4R
• MGC126851
• MGC138197

Background

Melanocortin 4 receptor (MC4R), a Melanocortin Receptor, has been shown to affect food intake and energy balance. Recently MC4R has been shown to modulate erectile function and sexual behavior (Van Der Ploeg et al. 2002).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Melanocortin-4 R Antibody (NBP2-26210)(1)

Publication using NBP2-26210

• McDaniel FK, Molden BM, Mohammad S et al. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to a-melanocyte-stimulating hormone (a-MSH). J Biol Chem 2012-06-01 [PMID: 22544740]

Bioinformatics

• Gene Symbol: MC4R
• Entrez:
  • 4160(Human)
• Uniprot:
  • NP_005903.2(Human)