Melanocortin-2 R/MC2R Antibody

Western Blot: MC2 Receptor Antibody [NB100-93419] - (1ug/ml) staining of Human Skin lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu, Fi
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Melanocortin-2 R/MC2R Antibody Summary

• Description: Novus Biologicals Goat Melanocortin-2 R/MC2R Antibody (NB100-93419) is a polyclonal antibody validated for use in IHC, WB and ELISA. Anti-Melanocortin-2 R/MC2R Antibody: Cited in 3 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence ENINNTARNNSDC corresponding to N-Terminus according to NP_000520.1.
• Epitope: ENINNTARNNSDC
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MC2R
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Approx. 40 kDa band observed in human skin lysates is reported in scientific literature (PMID: 16497811). Use in Immunohistochemistry-paraffin reported in scientific literature (PMID: 28837788).

Reactivity Notes

Fish reactivity reported in scientific literature (PMID: 28837788).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Melanocortin-2 R/MC2R Antibody

• ACTH receptor
• ACTHR
• ACTH-R
• ACTHRcorticotropin receptor
• adrenocorticotropic hormone receptor
• Adrenocorticotropin receptor
• MC2 receptor
• MC2R
• MC2-R
• melanocortin 2 receptor (adrenocorticotropic hormone)
• Melanocortin receptor 2
• Melanocortin-2 R
• Melanocortin2R
• Melanocortin-2R
• MGC125798

Background

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Melanocortin-2 R/MC2R Antibody (NB100-93419)(3)

Publications using NB100-93419

• Wang Y, Guo B, Guo Y, Qi N et Al. A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads Front Endocrinol (Lausanne) 2022-12-05 [PMID: 36465633]
• Kiilerich P, Servili A, Peron S et al. Regulation of the corticosteroid signalling system in rainbow trout HPI axis during confinement stress Gen. Comp. Endocrinol. 2017-08-21 [PMID: 28837788] (IHC-P, Fish)
• Kilianova Z, Basora N, Kilian P et al. Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization. Endocrinology 2006-05-01 [PMID: 16497811]

Bioinformatics

• Gene Symbol: MC2R
• Entrez:
  • 4158(Human)
• Uniprot:
  • NP_000520.1(Human)