MEKK3 Antibody (2H11) - BSA Free

• Reactivity: Hu
• Applications: ELISA
• Clone: 2H11
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

MEKK3 Antibody (2H11) - BSA Free Summary

• Description: Novus Biologicals Rabbit MEKK3 Antibody (2H11) - BSA Free (NBP3-26151) is a recombinant monoclonal antibody validated for use in ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant monoclonal antibody expressed in HEK293F cells
• Immunogen: A synthesized peptide derived from Human MEKK3 [UniProt Q99759]
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MAP3K3
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, and 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for MEKK3 Antibody (2H11) - BSA Free

• EC 2.7.11.25
• MAP/ERK kinase kinase 3
• MAP3K3
• MAPK/ERK kinase kinase 3
• MAPKKK3
• MAPKKK3MEKK 3
• MEK kinase 3
• MEKK3
• mitogen-activated protein kinase kinase kinase 3

Background

MEKK3 is a Ser/Thr protein kinase belonging to the MAP/ERK kinase kinase family (1). Closely related to MEKK2, MEKK3 is expressed in a multitude of tissues. MEKK3 directly regulates SAPKs and ERKs pathway via SEK and MEK1, respectively but not the p38 pathway (2) and is also involved in the NF-kB pathway (3). MEKK3 as well as MEKK2 bind, phosphorylate and activate MEK5 through their PB1 domain (4). hKSR-2 (human kinase suppressor of ras-2) has been shown to regulate the activity of MEKK3 (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAP3K3