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MEKK3 is a Ser/Thr protein kinase belonging to the MAP/ERK kinase kinase family (1). Closely related to MEKK2, MEKK3 is expressed in a multitude of tissues. MEKK3 directly regulates SAPKs and ERKs pathway via SEK and MEK1, respectively but not the p38 pathway (2) and is also involved in the NF-kB pathway (3). MEKK3 as well as MEKK2 bind, phosphorylate and activate MEK5 through their PB1 domain (4). hKSR-2 (human kinase suppressor of ras-2) has been shown to regulate the activity of MEKK3 (5).
![Western Blot MEKK3 Antibody (576240) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MEKK3_MAB6095_Western_Blot_9447.jpg)
![Knockout Validated MEKK3 Antibody (576240) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MEKK3_MAB6095_Knockout_Validated_21958.jpg)
![Western Blot MEKK3 Antibody (576240) [Unconjugated]](http://images.novusbio.com/fullsize/mab6095_human-mekk3-mab-clone-576240-western-blot-121220257455221.jpg)
