MAVS Antibody (981240) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: IHC
• Clone: 981240
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

MAVS Antibody (981240) [Alexa Fluor® 750] Summary

• Immunogen: E.coli-derived recombinant human MAVS
  Arg37-Pro513
  Accession # Q7Z434
• Specificity: Detects human MAVS in direct ELISAs.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MAVS Antibody (981240) [Alexa Fluor® 750]

• CARD adapter inducing interferon beta
• CARD adapter inducing interferon-beta
• CARD adaptor inducing IFN-beta
• Cardif
• DKFZp547C224
• DKFZp666M015
• FLJ27482
• IFN-B promoter stimulator 1
• Interferon beta promoter stimulator protein 1
• interferon-beta promoter stimulator protein 1
• IPS-1
• IPS-1FLJ41962
• IPS1MGC3260
• KIAA1271FLJ35386
• MAVS
• mitochondrial antiviral signaling protein
• mitochondrial antiviral-signaling protein
• mitochondrial viral signaling protein
• Putative NF-kappa-B-activating protein 031N
• virus-induced signaling adapter variant 1b
• virus-induced signaling adaptor variant 1a
• Virus-induced-signaling adapter
• VISA
• VISAFLJ38051

Background

Mitochondrial antviral signaling protein (MAVS, also known as IPS-1, VISA, and CARDIF) is a ubiquitous, tail-anchored membrane protein inserted in the outer mitochondrial membrane (OMM), and is also found in the peroxisomal membrane and the mitochondrial associated membrane of the endoplasmic reticulum. Peroxisomal MAVS has been implicated in type II IFN-dependent antiviral response, while mitochondrial MAVS mediates longer lasting type I IFN dependent antiviral response. Mitochondrial reactive oxygen species (mROS) induce oligomerization of MAVS in the outer membrane plane of mitochondria to induce innate immunity to viral infection. MAVS undergoes RIG-I-like receptors (RLR)-induced formation of higher order structures ranging from dimers to prion-like aggregates that lead to the recruitment and activation of signaling proteins culminating in the activation of the transcription factors IRF-3 and NF-kappa B and transcription of IFNs

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for MAVS Antibody (FAB9694S). (Showing 1 - 1 of 1 FAQ).

1. Molecular weight of MAVS?
   • MAVS is a 540 aa protein with a predicted size of 56 kDa.

Bioinformatics

• Uniprot:
  • Q7Z434()