LXR beta/NR1H2 Antibody - BSA Free

Western Blot: LXR beta/NR1H2 Antibody [NBP1-76256] - Human lung tissue lysate with LXR-B antibody at (A) 1 and (B) 2 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

LXR beta/NR1H2 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human LXR-B. The immunogen is located within the first 50 amino acids of LXR-B. Amino Acid Squence: SPTVKEEGPEPWPG
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NR1H2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1-2 ug/ml
• Control Peptide:

  LXR beta/NR1H2 Peptide (NBP1-76256PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for LXR beta/NR1H2 Antibody - BSA Free

• Liver X receptor beta
• LXR beta
• LXR-b
• NER-I
• NERliver X receptor-beta
• NR1H2
• nuclear orphan receptor LXR-beta
• Nuclear receptor NER
• Nuclear receptor subfamily 1 group H member 2
• nuclear receptor subfamily 1, group H, member 2
• oxysterols receptor LXR-beta
• RIP15
• steroid hormone-nuclear receptor NER
• Ubiquitously-expressed nuclear receptorLXRB
• UNR
• UNRLX receptor beta

Background

LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NR1H2
• Entrez:
  • 7376(Human)
• Uniprot:
  • P55055(Human)