LRP-5 Antibody (747619) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB
• Clone: 747619
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

LRP-5 Antibody (747619) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human LRP-5 Intracellular Domain
  Phe1422-Ser1615
  Accession # O75197
• Specificity: Detects human LRP-5 Intracellular Domain in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with the intracellular domain of recombinant human LRP-6 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LRP-5 Antibody (747619) [Alexa Fluor® 750]

• BMND1
• BMND1OPTA1
• EVR1
• EVR4
• HBM
• low density lipoprotein receptor-related protein 5
• low density lipoprotein receptor-related protein 7
• low-density lipoprotein receptor-related protein 5
• LR3VBCH2
• LRP5
• LRP-5
• LRP7
• LRP7exudative vitreoretinopathy 1
• OPPG
• OPS
• OPTA1
• osteoporosis pseudoglioma syndrome
• VBCH2

Background

LRP-5 (low-density lipoprotein receptor-related protein 5) is a 1615 amino acid (aa), ~180‑200 kDa type I transmembrane glycoprotein. The 1353 aa extracellular domain (ECD) contains 20 class B LDLR, 4 EGF‑like, and 3 class A LDLR repeats. Human LRP-5 aa 745-1097 encompasses class B LDLR repeats #12-17 and EGF‑like repeat #3. It shares 94% aa identity with mouse and rat LRP-5, and 70% aa identity with human LRP-6 within corresponding regions. LRP-5 and LRP-6 mediate DKK effects on Wnt signaling. LRP-5 polymorphisms correlate with susceptibility and resistance to osteoporosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.