LRP-5 Products

Antibodies
LRP-5 Antibody
LRP-5 Antibody
NB100-1886
Species: Hu
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
LRP-5 Antibody
LRP-5 Antibody
AF6646
Species: Hu
Applications: WB
Host: Sheep Polyclonal
LRP-5 Antibody (747619)
LRP-5 Antibody (747619)
MAB6646
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Proteins
Recombinant Human LRP-5 Prote ...
Recombinant Human LRP-5 Protein
H00004041-Q01
Species: Hu
Applications: WB, ELISA, PA
LRP-5 Recombinant Protein Ant ...
LRP-5 Recombinant Protein Antigen
NBP2-37868PEP
Species: Hu
Applications: AC
RNAi
LRP-5 RNAi
LRP-5 RNAi
H00004041-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

LRP5 is involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Defects in LRP5 are a cause of autosomal dominant and autosomal recessive familial exudative vitreoretinopathy (FEVR). Autosomal dominant FEVR is also referred to as exudative vitreoretinopathy 1 (EVR1); also known as Criswick-Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100%, but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 4041
Alternate Names
  • low-density lipoprotein receptor-related protein 5
  • EVR4
  • low density lipoprotein receptor-related protein 7
  • LRP-5
  • EVR1
  • OPS
  • osteoporosis pseudoglioma syndrome
  • HBM
  • LRP7exudative vitreoretinopathy 1
  • LR3VBCH2
  • BMND1OPTA1
  • OPPG
  • low density lipoprotein receptor-related protein 5

Research Areas for LRP-5

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Phospho-Specific
Stem Cell Signaling Pathway
Vision
Wnt Signaling Pathway

Bioinformatics Tool for LRP-5

Discover related pathways, diseases and genes to LRP-5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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