Axin-1 Antibody


Western blot shows lysates of Raji human Burkitt's lymphoma cell line, Balb/3T3 mouse embryonic fibroblast cell line, and PC‑12 rat adrenal pheochromocytoma cell line. PVDF membrane was probed with 0.5 µg/mL of more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB

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Axin-1 Antibody Summary

E. coli-derived recombinant human Axin-1
Accession # O15169
Detects human, mouse and rat Axin-1 in Western blots.
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 0.5 ug/mL
Read Publications using
AF3287 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Axin-1 Antibody

  • axin 1
  • Axin1
  • Axin-1
  • AXINaxis inhibitor 1
  • Axis inhibition protein 1
  • fused, mouse, homolog of
  • hAxin
  • MGC52315


Axin-1 is a negative regulator of the Wnt signaling pathway, which is involved in regulation of embryonic axis formation in vertebrates. Axin-1 binds to beta -catenin and glycogen synthase kinase-3 (GSK-3) to promote beta -catenin phosphorylation and subsequent degradation. Axin-1 also binds to the adenomatous polyposis coli (APC) gene, a known tumor suppressor that also regulates beta -catenin.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Ch, Av-Du, Hu, Mu, Pm, Rt
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Species: Hu, Mu, Pm, Rt
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Applications: ICC/IF, IHC, IHC-Fr, IHC-P, WB
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Applications: CyTOF-ready, Flow, WB
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Publications for Axin-1 Antibody (AF3287)(9)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Immunoprecipitation, Western Blot.

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Western Blot
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Showing Publications 1 - 9 of 9.
Publications using AF3287 Applications Species
W Wang, P Liu, M Lavrijsen, S Li, R Zhang, S Li, WS van de Gee, HJG van de Wer, MP Peppelenbo, R Smits Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines Scientific Reports, 2021;11(1):7470. 2021 [PMID: 33811251] (Western Blot, Human) Western Blot Human
TW Parker, KL Neufeld APC controls Wnt-induced beta-catenin destruction complex recruitment in human colonocytes Sci Rep, 2020;10(1):2957. 2020 [PMID: 32076059] (Western Blot, Human) Western Blot Human
C Dittfeld, G Reimann, A Mieting, P Büttner, A Jannasch, K Plötze, G Steiner, SM Tugtekin, K Matschke Treatment with XAV-939 prevents in vitro calcification of human valvular interstitial cells PLoS ONE, 2018;13(12):e0208774. 2018 [PMID: 30532256] (Western Blot, Human) Western Blot Human
K Saito-Diaz, H Benchabane, A Tiwari, A Tian, B Li, JJ Thompson, AS Hyde, LM Sawyer, JN Jodoin, E Santos, LA Lee, RJ Coffey, RD Beauchamp, CS Williams, AK Kenworthy, DJ Robbins, Y Ahmed, E Lee APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway Dev. Cell, 2018;44(5):566-581.e8. 2018 [PMID: 29533772] (Western Blot, Mouse) Western Blot Mouse
Lebensohn A, Dubey R, Neitzel L, Tacchelly-Benites O, Yang E, Marceau C, Davis E, Patel B, Bahrami-Nejad Z, Travaglini K, Ahmed Y, Lee E, Carette J, Rohatgi R Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Elife, 0;5(0):. 0 [PMID: 27996937] (Western Blot, Mouse) Western Blot Mouse
Yu N, Kakunda M, Pham V, Lill J, Du P, Wongchenko M, Yan Y, Firestein R, Huang X HSP105 recruits protein phosphatase 2A to dephosphorylate beta-catenin. Mol Cell Biol, 2015;35(8):1390-400. 2015 [PMID: 25645927] (Immunoprecipitation, Human) Immunoprecipitation Human
Bao R, Christova T, Song S, Angers S, Yan X, Attisano L Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PLoS ONE, 2012;7(11):e48670. 2012 [PMID: 23144924] (Western Blot, Human) Western Blot Human
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. EMBO J., 2012;31(16):3384-97. 2012 [PMID: 22773187] (Western Blot, Human) Western Blot Human
Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB Canonical Wnt signaling negatively regulates platelet function. Proc. Natl. Acad. Sci. U.S.A., 2009;106(47):19836-41. 2009 [PMID: 19901330] (Western Blot, Human) Western Blot Human

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Gene Symbol AXIN1