Recombinant Human Wnt-3a Protein

Recombinant Human Wnt-3a (Catalog # 5036-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The ED50 is 1.7-fold better with more than twice the maximum response compared to the top competitor's Wnt-3a.

The lot-to-lot consistency of Recombinant Human Wnt-3a Protein (Catalog # 5036-WN) was assessed by testing the ability of three independent lots of the protein to induce alkaline phosphatase production in the MC3T3-E1 mouse preosteoblast cell line. Each trace on the graph represents data obtained from Recombinant Human Wnt-3a from a different manufacturing run. The ED50 for this effect is 5.00-25.0 ng/mL.

iPSC-derived human intestinal organoids were cultured using Cultrex™ UltiMatrix RGF Basement Membrane Extract (BME001-05) and intestinal organoid culture medium, which includes Recombinant Human Wnt-3a (Catalog # 5036-WN), Recombinant Human EGF (236-EG), Recombinant Human Noggin (6057-NG), and Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Human intestinal organoids were stained using a Rat Anti-Human/Mouse/Rat Vimentin Monoclonal Antibody (MAB2105; green) and a Goat Anti-Human/Mouse Desmin Antigen Affinity-purified Polyclonal Antibody (AF3844; red) to visualize myofibroblast cells and counterstained with DAPI (5748; blue). (B) Human intestinal organoids were stained using a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; green) and a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-44431; red) and counterstained with DAPI (5748; blue).

Adult stem cells isolated from human descending colon were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 30 days in intestinal organoid culture medium, which includes Recombinant Human Wnt-3a (Catalog # 5036-WN), Recombinant Human EGF (236-EG), Recombinant Human Noggin (6057-NG), and Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the intestinal organoid culture medium recipe in the human intestinal organoid culture protocol. (A) Organoids were fixed and stained with a Mouse Anti-Human MUC2 Monoclonal Antibody (Novus Biologicals; Catalog # NBP2-44431; green) to visualize intestinal goblet cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 10x magnification. (B) Organoids were fixed and stained with a Mouse Anti-Human Chromogranin A Monoclonal Antibody (MAB90981; green) to visualize enteroendocrine cells and counterstained with a Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (AF748; red) and DAPI (5748; blue). The image shown was taken at 20x magnification.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human Wnt-3a Protein Summary

• Details of Functionality: Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED₅₀ for this effect is 5.00-25.0 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED₅₀ for this effect is <500 ng/mL. Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
  Optimal concentrations should be determined by each laboratory for each application.
• Source: Chinese Hamster Ovary cell line, CHO-derived human Wnt-3a protein
  Ser19-Lys352
• Accession #: NP_149122
• N-terminal Sequence: Ser19
• Protein/Peptide Type: Recombinant Proteins
• Gene: WNT3A
• Purity: >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • Bioactivity2
• Theoretical MW: 37.4 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 40 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
• Purity: >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Wnt-3a Protein

• MGC119418
• MGC119419
• MGC119420
• protein Wnt-3a
• wingless-type MMTV integration site family, member 3A
• Wnt3a
• Wnt-3a

Background

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Human Wnt-3a shares 96% amino acid (aa) identity with mouse mouse, bovine and canine Wnt-3a, and 89%, 86% and 84% aa identity with chicken, Xenopus and zebrafish Wnt-3a, respectively. It also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13, 14).

1. Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864.
2. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880.
3. Korinek, V. et al. (1997) Science 275:1784.
4. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100.
5. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267.
6. Takada, R. et al. (2006) Dev. Cell 11:791.
7. Komekado, H. (2007) Genes Cells 12:521.
8. Dunty Jr. W. C. et al. (2008) Development 135:85.
9. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27.
10. Lee, S. M. et al. (2000) Development 127:457.
11. Takada, S. et al. (1994) Genes Dev. 8:174.
12. Willert, K. et al. (2003) Nature 423:6938.
13. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970.
14. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.

Publications for Wnt-3a (5036-WN)(334)

Publications using 5036-WN

• Ayad, NME;Lakins, JN;Ghagre, A;Ehrlicher, AJ;Weaver, VM; Tissue tension permits beta -catenin phosphorylation to drive mesoderm specification in human embryonic stem cells bioRxiv : the preprint server for biology 2023-07-15 [PMID: 37503095] (Bioassay, Human)
• Shabani, K;Pigeon, J;Benaissa Touil Zariouh, M;Liu, T;Saffarian, A;Komatsu, J;Liu, E;Danda, N;Becmeur-Lefebvre, M;Limame, R;Bohl, D;Parras, C;Hassan, BA; The temporal balance between self-renewal and differentiation of human neural stem cells requires the amyloid precursor protein Science advances 2023-06-16 [PMID: 37327344] (Bioassay, Human)
• Ding, J;Lee, SJ;Vlahos, L;Yuki, K;Rada, CC;van Unen, V;Vuppalapaty, M;Chen, H;Sura, A;McCormick, AK;Tomaske, M;Alwahabi, S;Nguyen, H;Nowatzke, W;Kim, L;Kelly, L;Vollrath, D;Califano, A;Yeh, WC;Li, Y;Kuo, CJ; Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice Nature communications 2023-06-02 [PMID: 37268690] (Bioassay, Human)
• Martinez-Curiel, R;Jansson, L;Tsupykov, O;Avaliani, N;Aretio-Medina, C;Hidalgo, I;Monni, E;Bengzon, J;Skibo, G;Lindvall, O;Kokaia, Z;Palma-Tortosa, S; Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons Stem cell reports 2023-05-10 [PMID: 37236198] (Bioassay, Human)
• Maylem, ERS;Spicer, LJ;Batalha, IM;Sch�tz, LF; Developmental and hormonal regulation of FBN1 and OR4M1 mRNA in bovine granulosa cells Domestic animal endocrinology 2023-04-25 [PMID: 37167929] (Bioassay, Bovine)
• G Cencelli, L Pacini, A De Luca, I Messia, A Gentile, Y Kang, V Nobile, E Tabolacci, P Jin, MG Farace, C Bagni Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals Cells, 2023-02-27;12(5):. 2023-02-27 [PMID: 36899894] (Bioassay, Human)
• YC Hsueh, RE Pratt, VJ Dzau, CP Hodgkinson Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2 Scientific Reports, 2023-03-09;13(1):3920. 2023-03-09 [PMID: 36894665] (Bioassay, Human)
• C Seidl, F Da Silva, K Zhang, K Wohlgemuth, H Omran, C Niehrs Mucociliary Wnt signaling promotes cilia biogenesis and beating Nature Communications, 2023-03-06;14(1):1259. 2023-03-06 [PMID: 36878953] (Bioassay, Frog)
• C Seidl, F Da Silva, K Zhang, K Wohlgemuth, H Omran, C Niehrs Mucociliary Wnt signaling promotes cilia biogenesis and beating Nature Communications, 2023;14(1):1259. 2023 [PMID: 36878953] (Bioassay, Frog)
• Y Shen, Y Chen, Y Lin, Y Li, P Liu, B Zhang, Y Wang, KC Chan, NK Mak, M Kahn, RZ Qi, H Yang CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma Cell Death & Disease, 2023-02-11;14(2):107. 2023-02-11 [PMID: 36774351] (Bioassay, Human)
• LH Cheng, CC Hsu, HW Tsai, WY Liao, PM Yang, TY Liao, HY Hsieh, TS Chan, KK Tsai ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression Cancer Research, 2023-03-15;0(0):. 2023-03-15 [PMID: 36638332] (Bioassay, Human)
• K Wang, F Ma, S Arai, Y Wang, A Varkaris, L Poluben, O Voznesensk, F Xie, X Zhang, X Yuan, SP Balk WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth Cancer Research, 2023-04-04;0(0):. 2023-04-04 [PMID: 36622276] (Bioassay, Human)
• K Stoletov, S Sanchez, I Gorroño, M Rabano, M Vivanco, R Kypta, JD Lewis Intravital imaging of Wnt/beta-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis Journal of Cell Science, 2023-02-10;0(0):. 2023-02-10 [PMID: 36621522] (Bioassay, Human)
• MG Lee, H Oh, JW Park, JS You, JW Han Nuclear S6K1 Enhances Oncogenic Wnt Signaling by Inducing Wnt/beta-Catenin Transcriptional Complex Formation International Journal of Molecular Sciences, 2022-12-18;23(24):. 2022-12-18 [PMID: 36555784] (Cell Culture, Human)
• D Song, J Shang, Y Long, M Zhong, L Li, J Chen, Y Xiang, H Tan, H Zhu, X Hong, FF Hou, H Fu, Y Liu Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating beta-catenin signaling JCI Insight, 2023-01-24;0(0):. 2023-01-24 [PMID: 36520532] (Cell Culture, Human)
• H Ngai, GA Barragán, G Tian, JC Balzeau, C Zhang, AN Courtney, L Guo, X Xu, MS Wood, JM Drabek, T Demberg, CM Sands, CN Chauvin-Fl, EJ Di Pierro, JM Rosen, LS Metelitsa LEF1 drives a central memory program and supports antitumor activity of natural killer T cells Cancer Immunology Research, 2023-02-03;0(0):. 2023-02-03 [PMID: 36484736] (Stimulation, Human)
• Y Shi, J Deng, X Sang, Y Wang, F He, X Chen, A Xu, F Wu Generation of Hepatocytes and Nonparenchymal Cell Codifferentiation System from Human-Induced Pluripotent Stem Cells Stem Cells International, 2022-11-22;2022(0):3222427. 2022-11-22 [PMID: 36467281] (Bioassay, Human)
• L Jiang, YJ Sun, XH Song, YY Sun, WY Yang, J Li, YJ Wu Ivermectin inhibits tumor metastasis by regulating the Wnt/beta-catenin/integrin beta1/FAK signaling pathway American journal of cancer research, 2022-10-15;12(10):4502-4519. 2022-10-15 [PMID: 36381328] (Bioassay, Human)
• K Nagano, K Yamana, H Saito, R Kiviranta, AC Pedroni, D Raval, C Niehrs, F Gori, R Baron R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton Elife, 2022-11-02;11(0):. 2022-11-02 [PMID: 36321691] (Bioassay, Mouse)
• WC Hwang, D Song, H Lee, C Oh, SH Lim, HJ Bae, ND Kim, G Han, DS Min Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer Experimental & Molecular Medicine, 2022-09-21;0(0):. 2022-09-21 [PMID: 36131027] (Bioassay, Human)
• Y Tian, W Wang, S Lautrup, H Zhao, X Li, PWN Law, ND Dinh, EF Fang, HH Cheung, WY Chan WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome Nature Communications, 2022-09-16;13(1):5456. 2022-09-16 [PMID: 36114168] (Bioassay, Human)
• A Fregnani, L Saggin, K Gianesin, L Quotti Tub, M Carraro, G Barilà, G Scapinello, G Bonetto, M Pesavento, T Berno, A Branca, C Gurrieri, R Zambello, G Semenzato, L Trentin, S Manni, F Piazza CK1alpha/RUNX2 Axis in the Bone Marrow Microenvironment: A Novel Therapeutic Target in Multiple Myeloma Cancers, 2022-08-29;14(17):. 2022-08-29 [PMID: 36077711] (Bioassay, Human)
• M Naumann, T Czempiel, AJ Lö beta ner, K Pape, E Beyreuther, S Löck, S Drukewitz, A Hennig, C von Neubec, B Klink, M Krause, D William, DE Stange, R Bütof, A Dietrich Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids Cancers, 2022-08-03;14(15):. 2022-08-03 [PMID: 35954444] (Cell Culture, Human)
• S Gupta, R Kawaguchi, E Heinrichs, S Gallardo, S Castellano, I Mandric, BG Novitch, SJ Butler In�vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion Oncogene, 2022-07-19;40(3):111119. 2022-07-19 [PMID: 35858555] (Bioassay, Human)
• R Moser, J Annis, O Nikolova, CJ Whatcott, KE Gurley, E Mendez, K Moran-Jone, C Dorrell, RC Sears, CJ Kuo, H Han, AV Biankin, C Grandori, DD Von Hoff, CJ Kemp Pharmacological targeting of TFIIH suppresses KRAS mutant pancreatic ductal adenocarcinoma and synergizes with TRAIL Cancer Research, 2022-09-16;0(0):. 2022-09-16 [PMID: 35819261] (Bioassay, Human)
• S Condello, M Prasad, R Atwani, D Matei Tissue transglutaminase activates integrin-linked kinase and beta-catenin in ovarian cancer The Journal of Biological Chemistry, 2022-07-08;0(0):102242. 2022-07-08 [PMID: 35810788] (Bioassay, Human)
• C Shen, A Nayak, LR Neitzel, F Yang, B Li, CH Williams, CC Hong, Y Ahmed, E Lee, DJ Robbins The Casein kinase 1alpha agonist pyrvinium attenuates Wnt-mediated CK1alpha degradation via interaction with the E3 ubiquitin ligase component Cereblon The Journal of Biological Chemistry, 2022-07-01;0(0):102227. 2022-07-01 [PMID: 35780831] (Bioassay, Human)
• V Lungova, K Wendt, SL Thibeault Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling Oncogene, 2022-08-23;0(0):. 2022-08-23 [PMID: 35770504] (Bioassay, Human)
• J Fu, L Jiang, B Yu, Y Liu, R Wei, Y Hu, WI Ho, B Yang, M Chu, HF Tse, J Yang Generation of a human iPSC line CIBi010-A with a reporter for ASGR1 using CRISPR/Cas9 Stem Cell Research, 2022-05-05;62(0):102800. 2022-05-05 [PMID: 35561459] (Bioassay, Human)
• J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids Biology, 2022-03-23;11(4):. 2022-03-23 [PMID: 35453693] (Bioassay, Human)
• CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 2022-02-21;11(0):. 2022-02-21 [PMID: 35188460] (Bioassay, Human)
• MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-02-15;38(7):110379. 2022-02-15 [PMID: 35172130] (Bioassay, Human)
• CW Wasson, B Caballero-, J Gillespie, E Derrett-Sm, J Mankouri, CP Denton, G Canettieri, NA Riobo-Del, F Del Galdo Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation Cells, 2022-02-03;11(3):. 2022-02-03 [PMID: 35159339] (Bioassay, Human)
• Z Li, Y Wu, ME Yates, N Tasdemir, A Bahreini, J Chen, KM Levine, NM Priedigkei, A Nasrazadan, S Ali, L Buluwela, S Arnesen, J Gertz, JK Richer, B Troness, D El-Ashry, Q Zhang, L Gerratana, Y Zhang, M Cristofani, MA Montanez, P Sundd, CT Wallace, SC Watkins, C Fumagalli, E Guerini-Ro, L Zhu, GC Tseng, N Wagle, JS Carroll, P Jank, C Denkert, MM Karsten, JU Blohmer, BH Park, PC Lucas, JM Atkinson, AV Lee, S Oesterreic Hotspot ESR1 mutations are multimodal and contextual modulators of breast cancer metastasis Cancer Research, 2022-04-01;0(0):. 2022-04-01 [PMID: 35078818] (Bioassay, Human)
• B Geleta, FS Tout, SC Lim, S Sahni, PJ Jansson, MV Apte, DR Richardson, Ž Kova?evi? Targeting Wnt/Tenascin C-Mediated Cross Talk between Pancreatic Cancer Cells and Stellate Cells via activation of the Metastasis Suppressor NDRG1 The Journal of Biological Chemistry, 2022-01-20;0(0):101608. 2022-01-20 [PMID: 35065073] (Bioassay, Human)
• Y Han, A Villarreal, G Gutierrez, Q Nguyen, P Sun, T Wu, B Sui, G Berx, T Brabletz, K Kessenbroc, YA Zeng, K Watanabe, X Dai Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1 Cell Reports, 2022-01-11;38(2):110240. 2022-01-11 [PMID: 35021086] (Bioassay, Mouse)
• M Romano, R Elgueta, D McCluskey, AM Ortega-Pri, E Stolarczyk, F Dazzi, B Lucendo-Vi, J Meseguer-R, J Williams, G Fanelli, DC Hay, FM Watt, G Lombardi Pluripotent Stem Cell-Derived Hepatocytes Inhibit T Cell Proliferation In Vitro through Tryptophan Starvation Cells, 2021-12-22;11(1):. 2021-12-22 [PMID: 35011586] (Bioassay, Human)
• V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 2021-12-14;37(11):110068. 2021-12-14 [PMID: 34910915] (Bioassay, Human)
• AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells Cell Stem Cell, 2021-12-01;0(0):. 2021-12-01 [PMID: 34856121] (Bioassay, Human)
• C Völkner, M Liedtke, R Untucht, A Hermann, MJ Frech Patient-Specific iPSC-Derived Neural Differentiated and Hepatocyte-like Cells, Carrying the Compound Heterozygous Mutation p.V1023Sfs*15/p.G992R, Present the &quot;Variant&quot; Biochemical Phenotype of Niemann-Pick Type C1 Disease International Journal of Molecular Sciences, 2021-11-10;22(22):. 2021-11-10 [PMID: 34830064] (Bioassay, Human)
• C Gil-Recio, S Montori, S Al Demour, MA Ababneh, E Ferrés-Pad, C Marti, E Ferrés-Ama, M Barajas, A Al Madhoun, M Atari Chemically Defined Conditions Mediate an Efficient Induction of Dental Pulp Pluripotent-Like Stem Cells into Hepatocyte-Like Cells Stem Cells International, 2021-11-08;2021(0):5212852. 2021-11-08 [PMID: 34795766] (Bioassay, Human)
• M Kowalski-J, H Schihada, A Turku, T Huber, TP Sakmar, G Schulte Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain Science Advances, 2021-11-10;7(46):eabj7917. 2021-11-10 [PMID: 34757789] (Bioassay, Human)
• SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human)
• S Hu, S Ren, Y Cai, J Liu, Y Han, Y Zhao, J Yang, X Zhou, X Wang Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-beta-catenin-STAT3 signaling Cell Death and Differentiation, 2021-11-06;0(0):. 2021-11-06 [PMID: 34743203] (Bioassay, Human)
• T Radaszkiew, M Nosková, K Gömöryová, O Vondálová, KA Radaszkiew, M Picková, R Víchová, T Gybe?, K Kaiser, L Demková, L Ku?erová, T Bárta, D Pot?šil, Z Zdráhal, K Sou?ek, V Bryja RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy Elife, 2021-10-27;10(0):. 2021-10-27 [PMID: 34702444] (Bioassay, Human)
• L Johnson Ch, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudás, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fi, A Zine Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs International Journal of Molecular Sciences, 2021-10-07;22(19):. 2021-10-07 [PMID: 34639189] (Bioassay, Human)
• L Chen, Z Xu, Q Li, Q Feng, C Zheng, Y Du, R Yuan, X Peng USP28 facilitates pancreatic cancer progression through activation of Wnt/beta-catenin pathway via stabilising FOXM1 Cell Death & Disease, 2021-09-28;12(10):887. 2021-09-28 [PMID: 34584067] (Bioassay, Human)
• C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling Nature Communications, 2021-09-06;12(1):5263. 2021-09-06 [PMID: 34489457] (Bioassay, Human)
• A Sagara, K Nakata, S Matsumoto, W Guan, T Shinkawa, C Iwamoto, N Ikenaga, K Ohuchida, M Nakamura Repositioning of duloxetine to target pancreatic stellate cells Oncology Letters, 2021-08-20;22(4):744. 2021-08-20 [PMID: 34466156] (Bioassay, Human)
• M Yang, YM Han, Q Han, XZ Rong, XF Liu, XY Ln KCTD11 inhibits progression of lung cancer by binding to beta-catenin to regulate the activity of the Wnt and Hippo pathways Journal of Cellular and Molecular Medicine, 2021-08-28;0(0):. 2021-08-28 [PMID: 34453479] (Bioassay, Human)
• Y Kang, Y Zhou, Y Li, Y Han, J Xu, W Niu, Z Li, S Liu, H Feng, W Huang, R Duan, T Xu, N Raj, F Zhang, J Dou, C Xu, H Wu, GJ Bassell, ST Warren, EG Allen, P Jin, Z Wen A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Nature Neuroscience, 2021-08-19;0(0):. 2021-08-19 [PMID: 34413513] (Bioassay, Human)
• AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (Bioassay, Human)
• KM Mackinlay, BA Weatherbee, V Souza Rosa, CE Handford, G Hudson, T Coorens, LV Pereira, S Behjati, L Vallier, MN Shahbazi, M Zernicka-G An in vitro stem cell model of human epiblast and yolk sac interaction Elife, 2021-08-17;10(0):. 2021-08-17 [PMID: 34403333] (Bioassay, Human)
• S Hellman Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics Veterinary research, 2021-08-14;52(1):108. 2021-08-14 [PMID: 34391473] (Bioassay, Equine)
• I Fischer, J Küchler, C Schaar, T Fisch, J Cernoch, K Fischer, V Fernández, P Kühnen, H Stachelsch Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome Stem Cell Research, 2021-06-10;54(0):102417. 2021-06-10 [PMID: 34119956] (Cell Culture, Human)
• P Paclíková, TW Radaszkiew, D Pot?šil, J Harnoš, Z Zdráhal, V Bryja Roles of individual human Dishevelled paralogs in the Wnt signalling pathways Cellular Signalling, 2021-05-31;85(0):110058. 2021-05-31 [PMID: 34082011] (Cell Culture, Human)
• O Kwon, KB Jung, KR Lee, YS Son, H Lee, JJ Kim, K Kim, S Lee, YK Song, J Jung, K Park, DS Kim, MJ Son, MO Lee, TS Han, HS Cho, SJ Oh, H Chung, SH Kim, KS Chung, J Kim, CR Jung, MY Son The development of a functional human small intestinal epithelium model for drug absorption Science Advances, 2021-06-02;7(23):. 2021-06-02 [PMID: 34078609] (Bioassay, Human)
• TW Fowler, TL Mitchell, CY Janda, L Xie, S Tu, H Chen, H Zhang, J Ye, B Ouyang, TZ Yuan, SJ Lee, M Newman, N Tripuranen, ES Rego, D Mutha, A Dilip, M Vuppalapat, H Baribault, WC Yeh, Y Li Development of selective bispecific Wnt mimetics for bone loss and repair Nature Communications, 2021-05-31;12(1):3247. 2021-05-31 [PMID: 34059688] (Bioassay, Human)
• T Ebisudani, S Sugimoto, K Haga, A Mitsuishi, R Takai-Toda, M Fujii, K Toshimitsu, J Hamamoto, K Sugihara, T Hishida, H Asamura, K Fukunaga, H Yasuda, K Katayama, T Sato Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening Cell Reports, 2021-05-19;0(0):109218. 2021-05-19 [PMID: 34038715] (Bioassay, Human)
• W Liu, Z Zhan, M Zhang, B Sun, Q Shi, F Luo, M Zhang, W Zhang, Y Hou, X Xiao, Y Li, H Feng KAT6A, a novel regulator of &amp;beta-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1 Theranostics, 2021-04-15;11(13):6278-6292. 2021-04-15 [PMID: 33995658] (Bioassay, Human)
• X Yang, F Shao, D Guo, W Wang, J Wang, R Zhu, Y Gao, J He, Z Lu WNT/&amp;beta-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis Cell Death & Disease, 2021-05-08;12(5):462. 2021-05-08 [PMID: 33966037] (Bioassay, Human)
• JN Kuehner, J Chen, EC Bruggeman, F Wang, Y Li, C Xu, ZT McEachin, Z Li, L Chen, CM Hales, Z Wen, J Yang, B Yao 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer&#039;s disease Cell Reports, 2021-04-27;35(4):109042. 2021-04-27 [PMID: 33910000] (Bioassay, Human)
• QD Deng, XP Lei, YH Zhong, MS Chen, YY Ke, Z Li, J Chen, LJ Huang, Y Zhang, L Liang, ZX Lin, Q Liu, SP Li, XY Yu Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting &amp;beta-catenin-mediated epithelial-mesenchymal transition Acta pharmacologica Sinica, 2021-04-23;0(0):. 2021-04-23 [PMID: 33893396] (Bioassay, Human)
• N Raj, ZT McEachin, W Harousseau, Y Zhou, F Zhang, ME Merritt-Ga, JM Taliaferro, M Kalinowska, SG Marro, CM Hales, E Berry-Krav, MW Wolf-Ochoa, V Martinez-C, M Wernig, L Chen, E Klann, ST Warren, P Jin, Z Wen, GJ Bassell Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis Cell Reports, 2021-04-13;35(2):108991. 2021-04-13 [PMID: 33852833] (Bioassay, Human)
• YH Cui, S Yang, J Wei, CR Shea, W Zhong, F Wang, P Shah, MG Kibriya, X Cui, H Ahsan, C He, YY He Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis Nature Communications, 2021-04-12;12(1):2183. 2021-04-12 [PMID: 33846348] (Western Blot, Human)
• S Akbari, ? Kunter, Y Azbazdar, G Ozhan, N Atabey, ZF Karagonlar, E Erdal LGR5/R-Spo1/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines Cellular Signalling, 2021-03-06;0(0):109972. 2021-03-06 [PMID: 33684507] (Bioassay, Human)
• J Quandt, S Arnovitz, L Haghi, J Woehlk, A Mohsin, M Okoreeh, PS Mathur, AO Emmanuel, A Osman, M Krishnan, SB Morin, AT Pearson, RF Sweis, J Pekow, CR Weber, K Khazaie, F Gounari Wnt-&amp;beta-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression Nature Immunology, 2021-03-04;0(0):. 2021-03-04 [PMID: 33664518] (Bioassay, Human)
• D Baek, KH Park, KM Lee, S Jung, S Joung, J Kim, JW Lee Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells Cell Death & Disease, 2021-03-04;12(3):238. 2021-03-04 [PMID: 33664230] (Bioassay, Human)
• J Du, H Liu, X Mao, Y Qin, C Fan ATF4 promotes lung cancer cell proliferation and invasion partially through regulating Wnt/&amp;beta-catenin signaling International Journal of Medical Sciences, 2021-01-29;18(6):1442-1448. 2021-01-29 [PMID: 33628101] (Bioassay, Human)
• A Sinha, VB Fan, AB Ramakrishn, N Engelhardt, J Kennell, KM Cadigan Repression of Wnt/&amp;beta-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2 Science Advances, 2021-02-17;7(8):. 2021-02-17 [PMID: 33597243] (Bioassay, Human)
• PL Ramanujam, S Mehrotra, RP Kumar, S Verma, G Deshpande, RK Mishra, S Galande Global chromatin organizer SATB1 acts as a context-dependent regulator of the Wnt/Wg target genes Scientific Reports, 2021-02-09;11(1):3385. 2021-02-09 [PMID: 33564000] (Bioassay, Human)
• Q Yan, Y Zhang, X Fang, B Liu, TL Wong, L Gong, S Liu, D Yu, M Liu, L Jiang, X Wang, T Wei, Y Jia, L Li, L Sun, Y Tang, N Zhou, YF Yuan, Y Li, S Ma, XY Guan PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors Cell Death and Differentiation, 2021-01-26;0(0):. 2021-01-26 [PMID: 33500560] (Bioassay, Human)
• K Husain, D Coppola, CS Yang, MP Malafa Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis Scientific Reports, 2021-01-26;11(1):2185. 2021-01-26 [PMID: 33500430] (Bioassay, Human)
• M Tajan, M Hennequart, EC Cheung, F Zani, AK Hock, N Legrave, ODK Maddocks, RA Ridgway, D Athineos, A Suárez-Bon, RL Ludwig, L Novellasde, N Angelis, VSW Li, G Vlachogian, N Valeri, N Mainolfi, V Suri, A Friedman, M Manfredi, K Blyth, OJ Sansom, KH Vousden Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy Nature Communications, 2021-01-14;12(1):366. 2021-01-14 [PMID: 33446657] (Bioassay, Human)
• CL Wu, A Dicks, N Steward, R Tang, DB Katz, YR Choi, F Guilak Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis Nature Communications, 2021-01-13;12(1):362. 2021-01-13 [PMID: 33441552] (Bioassay, Human)
• R Santos, SB Linker, S Stern, APD Mendes, MN Shokhirev, G Erikson, L Randolph-M, V Racha, Y Kim, JR Kelsoe, AG Bang, M Alda, MC Marchetto, FH Gage Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients Molecular Psychiatry, 2021-01-04;0(0):. 2021-01-04 [PMID: 33398088] (Bioassay, Human)
• A Moiseenko, AI Vazquez-Ar, V Kheirollah, X Chu, A Tata, S Rivetti, S Günther, K Lebrigand, S Herold, T Braun, B Mari, S De Langhe, G Kwapiszews, A Günther, C Chen, W Seeger, PR Tata, JS Zhang, S Bellusci, E El Agha Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration Cell Reports, 2020-12-22;33(12):108549. 2020-12-22 [PMID: 33357434] (Bioassay, Human)
• MP Srikanth, RA Feldman Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease Biomolecules, 2020-12-03;10(12):. 2020-12-03 [PMID: 33287247] (Bioassay, Human)
• F Michielin, GG Giobbe, C Luni, Q Hu, I Maroni, MR Orford, A Manfredi, L Di Filippo, AL David, D Cacchiarel, P De Coppi, S Eaton, N Elvassore The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs Cell Rep, 2020-12-01;33(9):108453. 2020-12-01 [PMID: 33264615] (Bioassay, Human)
• AJ Bilotta, C Ma, W Yang, Y Yu, Y Yu, X Zhao, Z Zhou, S Yao, SM Dann, Y Cong Propionate Enhances Cell Speed and Persistence to Promote Intestinal Epithelial Turnover and Repair Cell Mol Gastroenterol Hepatol, 2020-11-22;0(0):. 2020-11-22 [PMID: 33238220] (Cell Culture, Mouse)
• J Wang, L Gong, W Zhang, W Chen, H Pan, Y Zeng, X Liang, J Ma, G Zhang, H Wang Wnt/&amp;beta-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-&amp;kappaB-dependent innate immune response Veterinary Microbiology, 2020-10-23;251(0):108904. 2020-10-23 [PMID: 33181435] (Cell Culture, Primate (Chlorocebus aethiops))
• S Wu, H Wei, M Chu, Z Weng Generation of a human iPSC line CIBi008-A from amniotic fluid-derived cells of a fetus with &amp;beta-thalassemia carrying variants of -28A�&gt;�G and IVS-II-654C�&gt;�T in HBB Stem Cell Res, 2020-10-29;49(0):102074. 2020-10-29 [PMID: 33157391] (Cell Culture, Human)
• L Wei, P Li, Y Luo, M Zhang, T Yan, Y Yang, Y Han, S Liu, E Wang PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin Onco Targets Ther, 2020-10-08;13(0):10025-10037. 2020-10-08 [PMID: 33116587] (Bioassay, Human)
• S Pagliari, V Vinarsky, F Martino, AR Perestrelo, J Oliver De, G Caluori, J Vrbsky, P Mozetic, A Pompeiano, A Zancla, SG Ranjani, P Skladal, D Kytyr, Z Zdráhal, G Grassi, M Sampaolesi, A Rainer, G Forte YAP-TEAD1 control of cytoskeleton dynamics and intracellular tension guides human pluripotent stem cell mesoderm specification Cell Death Differ, 2020-10-28;0(0):. 2020-10-28 [PMID: 33116297] (Bioassay, Human)
• S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia PLoS ONE, 2020-10-13;15(10):e0240120. 2020-10-13 [PMID: 33048949] (Cell Culture, Human)
• K Dunbar, A Valanciute, A Lima, PF Vinuela, T Jamieson, V Rajasekara, J Blackmur, AM Ochocka-Fo, A Guazzelli, P Cammareri, MJ Arends, OJ Sansom, KB Myant, SM Farrington, MG Dunlop, FVN Din Aspirin Rescues Wnt-Driven Stem-like Phenotype in Human Intestinal Organoids and Increases the Wnt Antagonist Dickkopf-1 Cell Mol Gastroenterol Hepatol, 2020-09-22;0(0):. 2020-09-22 [PMID: 32971322] (Cell Culture, Human)
• JC Lim, SH Bae, G Lee, CJ Ryu, YJ Jang Activation of &amp;beta-catenin by TGF-&amp;beta1 promotes ligament-fibroblastic differentiation and inhibits cementoblastic differentiation of human periodontal ligament cells Stem Cells, 2020-09-15;0(0):. 2020-09-15 [PMID: 32930424] (Cell Culture, Human)
• M Zhu, T Iwano, S Takeda Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro-Stem Cell of Fallopian Epithelium Biomolecules, 2020-09-03;10(9):. 2020-09-03 [PMID: 32899226] (Bioassay, Porcine)
• Y Gong, S Yuan, J Sun, Y Wang, S Liu, R Guo, W Dong, R Li R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/beta-Catenin Signaling Front Physiol, 2020-08-07;11(0):918. 2020-08-07 [PMID: 32848860] (Bioassay, Cell Culture, Human)
• W Chong, H Zhang, Z Guo, L Yang, Y Shao, X Liu, Y Zhao, Z Wang, M Zhang, C Guo, L Fu, Y Ma, F Gu Aquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting &amp;beta-catenin degradation to enhance TopoII&amp;alpha activity Cell Death Differ., 2020-08-19;0(0):. 2020-08-19 [PMID: 32814878] (Bioassay, Human)
• L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 2020-08-11;0(0):. 2020-08-11 [PMID: 32783886] (Bioassay, Human)
• T Sawada, TE Chater, Y Sasagawa, M Yoshimura, N Fujimori-T, K Tanaka, KJM Benjamin, ACM Paquola, JA Erwin, Y Goda, I Nikaido, T Kato Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids Mol. Psychiatry, 2020-08-07;0(0):. 2020-08-07 [PMID: 32764691] (Bioassay, Human)
• S Grosswendt, H Kretzmer, ZD Smith, AS Kumar, S Hetzel, L Wittler, S Klages, B Timmermann, S Mukherji, A Meissner Epigenetic regulator function through mouse gastrulation Nature, 2020-07-29;584(7819):102-108. 2020-07-29 [PMID: 32728215] (Bioassay, Mouse)
• Y Wu, M Sarkissyan, O Ogah, J Kim, JV Vadgama Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers Cancers (Basel), 2020-07-16;12(7):. 2020-07-16 [PMID: 32708561] (Cell Culture, Human)
• Z Dantes, HY Yen, N Pfarr, C Winter, K Steiger, A Muckenhube, A Hennig, S Lange, T Engleitner, R Öllinger, R Maresch, F Orben, I Heid, G Kaissis, K Shi, G Topping, F Stögbauer, M Wirth, K Peschke, A Papargyrio, M Rezaee-Ogh, K Feldmann, AP Schäfer, R Ranjan, C Lubeseder-, DE Stange, T Welsch, M Martignoni, GO Ceyhan, H Friess, A Herner, L Liotta, M Treiber, G von Figura, M Abdelhafez, P Klare, C Schlag, H Algül, J Siveke, R Braren, G Weirich, W Weichert, D Saur, R Rad, RM Schmid, G Schneider, M Reichert Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology JCI Insight, 2020-08-06;5(15):. 2020-08-06 [PMID: 32614802] (Bioassay, Cell Culture, Human)
• X Shi, W Lin, X Gao, W Xie, JA Golden, T Tao Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein Biosci. Rep., 2020-07-31;40(7):. 2020-07-31 [PMID: 32608477] (Bioassay, Human)
• W Kawarazaki, R Mizuno, M Nishimoto, N Ayuzawa, D Hirohama, K Ueda, F Kawakami-M, S Oba, T Marumo, T Fujita Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency J. Clin. Invest., 2020-08-03;0(0):. 2020-08-03 [PMID: 32597829] (Cell Culture, Human)
• S Xu, RWS Chan, T Li, EHY Ng, WSB Yeung Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation Stem Cell Res Ther, 2020-06-17;11(1):239. 2020-06-17 [PMID: 32552749] (Bioassay, Human)
• K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner Notch signalling drives synovial fibroblast identity and arthritis pathology Nature, 2020-04-22;582(7811):259-264. 2020-04-22 [PMID: 32499639] (Bioassay, Human)
• NY Loh, JEN Minchin, KE Pinnick, M Verma, M Todor?evi?, N Denton, JE Moustafa, JP Kemp, CL Gregson, DM Evans, MJ Neville, KS Small, MI McCarthy, A Mahajan, JF Rawls, F Karpe, C Christodou RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro Nat Commun, 2020-06-03;11(1):2797. 2020-06-03 [PMID: 32493999] (Bioassay, Human)
• FH Brasil da, MS Lewis, A Truong, DD Carson, MC Farach-Car SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models PLoS ONE, 2020-05-15;15(5):e0230354. 2020-05-15 [PMID: 32413029] (Cell Culture, Human)
• M Bowers, T Liang, D Gonzalez-B, S Zocher, BN Jaeger, WJ Kovacs, C Röhrl, KML Cramb, J Winterer, M Kruse, S Dimitrieva, RW Overall, T Wegleiter, H Najmabadi, CF Semenkovic, G Kempermann, C Földy, S Jessberger FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits Cell Stem Cell, 2020-05-07;0(0):. 2020-05-07 [PMID: 32386572] (Bioassay, Human)
• A Fleischer, S Vallejo-Dí, JM Martín-Fer, A Sánchez-Gi, M Castresana, A Del Pozo, A Esquisabel, S Ávila, JL Castrillo, E Gaínza, JL Pedraz, M Viñas, D Bachiller iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation Mol Ther Methods Clin Dev, 2020-04-18;17(0):858-870. 2020-04-18 [PMID: 32373648] (Cell Culture, Human)
• F He, N Li, HB Huang, JB Wang, XF Yang, HD Wang, W Huang, FR Li LSD1 inhibition yields functional insulin-producing cells from human embryonic stem cells Stem Cell Res Ther, 2020-04-28;11(1):163. 2020-04-28 [PMID: 32345350] (Bioassay, Human)
• E Flores-Her, DM Velázquez, MC Castañeda-, G Fuentes-Ga, G Fonseca-Ca, JK Yamamoto-F, MT Romero-Avi, JA García-Sái, M Robles-Flo Canonical and non-canonical Wnt signaling are simultaneously activated by Wnts in colon cancer cells Cell. Signal., 2020-04-10;72(0):109636. 2020-04-10 [PMID: 32283254] (Bioassay, Human)
• Q Li, Y Sun, GK Jarugumill, S Liu, K Dang, JL Cotton, J Xiol, PY Chan, M DeRan, L Ma, R Li, LJ Zhu, JH Li, AB Leiter, YT Ip, FD Camargo, X Luo, RL Johnson, X Wu, J Mao Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription Cell Stem Cell, 2020-04-06;26(5):675-692.e8. 2020-04-06 [PMID: 32259481] (Cell Culture, Human)
• S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi Generation of intestinal organoids derived from human pluripotent stem cells for drug testing Sci Rep, 2020-04-06;10(1):5989. 2020-04-06 [PMID: 32249832] (Bioassay, Human)
• A El-Sehemy, HJ Selvadurai, A Ortin-Mart, NT Pokrajac, Y Mamatjan, N Tachibana, KJ Rowland, L Lee, NI Park, KD Aldape, P Dirks, VA Wallace Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest., 2020-06-01;0(0):. 2020-06-01 [PMID: 32182224] (Cell Culture, Human)
• R Griffiths, S Woods, A Cheng, P Wang, S Griffiths-, M Ronshaugen, SJ Kimber The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis Sci Rep, 2020-03-16;10(1):4744. 2020-03-16 [PMID: 32179818] (Bioassay, Human)
• WY Liao, CC Hsu, TS Chan, CJ Yen, WY Chen, HW Pan, KK Tsai Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma Stem Cell Reports, 2020-03-10;14(3):462-477. 2020-03-10 [PMID: 32160521] (Bioassay, Human)
• V Uribe-Etxe, P García-Gal, M Pérez-Garr, M Casado-And, I Irastorza, F Unda, G Ibarretxe, N Subirán Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells Cells, 2020-03-07;9(3):. 2020-03-07 [PMID: 32156036] (Cell Culture, Mouse)
• R Castro-Viñ, C Sanjurjo-R, M Piñeiro-Ra, T Hermida-Gó, S Rodríguez-, N Oreiro, J de Toro, I Fuentes, FJ Blanco, S Díaz-Prado Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts Sci Rep, 2020-03-06;10(1):4272. 2020-03-06 [PMID: 32144293] (Cell Culture, Human)
• S Komura, T Satake, A Goto, H Aoki, H Shibata, K Ito, A Hirakawa, Y Yamada, H Akiyama Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice Sci Rep, 2020-03-04;10(1):3992. 2020-03-04 [PMID: 32132649] (Bioassay, Human)
• M Liu, Q Yan, Y Sun, Y Nam, L Hu, JH Loong, Q Ouyang, Y Zhang, HL Li, FE Kong, L Li, Y Li, MM Li, W Cheng, LX Jiang, S Fang, XD Yang, JQ Mo, YF Gong, YQ Tang, Y Li, YF Yuan, NF Ma, G Lin, S Ma, JG Wang, XY Guan A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets Proc. Natl. Acad. Sci. U.S.A., 2020-03-02;0(0):. 2020-03-02 [PMID: 32123069] (Cell Culture, Human)
• JP Gleeson, HQ Estrada, M Yamashita, CN Svendsen, SR Targan, RJ Barrett Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD Int J Mol Sci, 2020-02-20;21(4):. 2020-02-20 [PMID: 32093254] (Cell Culture, Human)
• M Díaz-Corán, CM Lin, S Liebner, DA Antonetti Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability J. Biol. Chem., 2020-02-21;0(0):. 2020-02-21 [PMID: 32086377] (Bioassay, Bovine)
• PN Kluz, R Kolb, Q Xie, N Borcherdin, Q Liu, Y Luo, MC Kim, L Wang, Y Zhang, W Li, C Stipp, KN Gibson-Cor, C Zhao, HH Qi, A Bellizzi, AW Tao, S Sugg, RJ Weigel, D Zhou, X Shen, W Zhang Cancer cell-intrinsic function of CD177 in attenuating beta-catenin signaling Oncogene, 2020-02-10;39(14):2877-2889. 2020-02-10 [PMID: 32042113] (Bioassay, Human)
• L Omer, L Hindi, G Militello, KB Stivers, KC Tien, NL Boyd Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment Dis Model Mech, 2020-04-06;0(0):. 2020-04-06 [PMID: 32005714] (Cell Culture, Human)
• O McGinn, AV Ward, LM Fettig, D Riley, J Ivie, KV Paul, P Kabos, J Finlay-Sch, CA Sartorius Cytokeratin 5 alters beta-catenin dynamics in breast cancer cells Oncogene, 2020-01-27;39(12):2478-2492. 2020-01-27 [PMID: 31988452] (Bioassay, Human)
• P Kozielewic, A Turku, CF Bowin, J Petersen, J Valnohova, MCA Cañizal, Y Ono, A Inoue, C Hoffmann, G Schulte Structural insight into small molecule action on Frizzleds Nat Commun, 2020-01-21;11(1):414. 2020-01-21 [PMID: 31964872] (Cell Culture, Human)
• KH Grinnemo, M Löfling, L Nathanson, R Baumgartne, DFJ Ketelhuth, V Beljanski, LC Davies, C Österholm Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells Stem Cell Res Ther, 2019-12-04;10(1):371. 2019-12-04 [PMID: 31801632] (Bioassay, Human)
• AP Singh, YH Hung, MT Shanahan, M Kanke, A Bonfini, MK Dame, M Biraud, BCE Peck, OO Oyesola, JM Freund, RL Cubitt, EG Curry, LM Gonzalez, GA Bewick, ED Tait-Wojno, NA Kurpios, S Ding, JR Spence, CM Dekaney, N Buchon, P Sethupathy Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner Cell Mol Gastroenterol Hepatol, 2019-11-19;0(0):. 2019-11-19 [PMID: 31756561] (Tissue Culture, Porcine)
• Z Ye, S Mittag, M Schmidt, A Simm, R Horstkorte, O Huber Wnt Glycation Inhibits Canonical Signaling Cells, 2019-10-25;8(11):. 2019-10-25 [PMID: 31731544] (Cell Culture, Human)
• R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Nat Commun, 2019-11-01;10(1):5016. 2019-11-01 [PMID: 31676788] (Cell Culture, Human)
• RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, HW Lim, KH Kaestner, JD Rabinowitz, P Seale PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism Cell Stem Cell, 2019-09-26;0(0):. 2019-09-26 [PMID: 31564549] (Bioassay, Mouse)
• V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 2019-09-24;10(1):4161. 2019-09-24 [PMID: 31551422] (Bioassay, Human)
• F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore In vitro metabolic zonation through oxygen gradient on a chip Sci Rep, 2019-09-19;9(1):13557. 2019-09-19 [PMID: 31537830] (Bioassay, Human)
• CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor PLoS ONE, 2019-09-19;14(9):e0222779. 2019-09-19 [PMID: 31536596] (Bioassay, Human)
• S Akbari, GG Sevinç, N Ersoy, O Basak, K Kaplan, K Sevinç, E Ozel, B Sengun, E Enustun, B Ozcimen, A Bagriyanik, N Arslan, TT Önder, E Erdal Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling Stem Cell Reports, 2019-09-12;13(4):627-641. 2019-09-12 [PMID: 31522975] (Cell Culture, Human)
• AG Hawkins, CM Julian, S Konzen, S Treichel, ER Lawlor, KM Bailey Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma Neoplasia, 2019-09-13;21(10):1063-1072. 2019-09-13 [PMID: 31521948] (Bioassay, Human)
• Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu Controlled modelling of human epiblast and amnion development using stem cells Nature, 2019-09-11;573(7774):421-425. 2019-09-11 [PMID: 31511693] (Bioassay, Human)
• C Praça, SC Rosa, E Sevin, R Cecchelli, MP Dehouck, LS Ferreira Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells Stem Cell Reports, 2019-09-05;13(4):599-611. 2019-09-05 [PMID: 31495714] (Bioassay, Human)
• CP Nielsen, KK Jernigan, NL Diggins, DJ Webb, JA MacGurn USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification Cell Rep, 2019-07-23;28(4):1074-1089.e5. 2019-07-23 [PMID: 31340145] (Cell Culture, Human)
• T Wang, P Nimkingrat, CA Smith, A Cheng, TE Hardingham, SJ Kimber Enhanced chondrogenesis from human embryonic stem cells Stem Cell Res, 2019-07-09;39(0):101497. 2019-07-09 [PMID: 31326745] (Bioassay, Human)
• Y Wen, H Yang, J Wu, A Wang, X Chen, S Hu, Y Zhang, D Bai, Z Jin COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells Theranostics, 2019-05-31;9(15):4265-4286. 2019-05-31 [PMID: 31285761] (Cell Culture, Human)
• KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 2019-07-04;8(7):. 2019-07-04 [PMID: 31277507] (Bioassay, Human)
• K Aripaka, SK Gudey, G Zang, A Schmidt, SS Åhrling, L Österman, A Bergh, J von Hofste, M Landström TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer EBioMedicine, 2019-06-28;0(0):. 2019-06-28 [PMID: 31262711] (Bioassay, Human)
• H Zhao, C Zhao, H Li, D Zhang, G Liu E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway J. Exp. Clin. Cancer Res., 2019-06-24;38(1):276. 2019-06-24 [PMID: 31234887] (Bioassay, Human)
• M Huang, J Tailor, Q Zhen, AH Gillmor, ML Miller, H Weishaupt, J Chen, T Zheng, EK Nash, LK McHenry, Z An, F Ye, Y Takashima, J Clarke, H Ayetey, FMG Cavalli, B Luu, BS Moriarity, S Ilkhanizad, L Chavez, C Yu, KM Kurian, T Magnaldo, N Sevenet, P Koch, SM Pollard, P Dirks, MP Snyder, DA Largaespad, YJ Cho, JJ Phillips, FJ Swartling, AS Morrissy, M Kool, SM Pfister, MD Taylor, A Smith, WA Weiss Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis Cell Stem Cell, 2019-06-13;0(0):. 2019-06-13 [PMID: 31204176] (Bioassay, Human)
• G Ferrer-May, N Niell, R Cantero, JM González-S, L Del Peso, A Muñoz, MJ Larriba Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts Sci Rep, 2019-05-30;9(1):8085. 2019-05-30 [PMID: 31147591] (Bioassay, Human)
• Z Yan, K Ohuchida, S Fei, B Zheng, W Guan, H Feng, S Kibe, Y Ando, K Koikawa, T Abe, C Iwamoto, K Shindo, T Moriyama, K Nakata, Y Miyasaka, T Ohtsuka, K Mizumoto, M Hashizume, M Nakamura Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis J. Exp. Clin. Cancer Res., 2019-05-27;38(1):221. 2019-05-27 [PMID: 31133044] (Bioassay, Human)
• K Abe, A Shimada, S Tayama, H Nishikawa, T Kaneko, S Tsuda, A Karaiwa, T Matsui, T Ishitani, H Takeda Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite Cell Rep, 2019-04-16;27(3):928-939.e4. 2019-04-16 [PMID: 30995487] (Bioassay, In Vivo)
• K Kaiser, D Gyllborg, J Procházka, A Salašová, P Kompaníkov, FL Molina, R Laguna-Goy, T Radaszkiew, J Harnoš, M Procházkov, D Pot?šil, RA Barker, ÁG Casado, Z Zdráhal, R Sedlá?ek, E Arenas, JC Villaescus, V Bryja WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis Nat Commun, 2019-04-02;10(1):1498. 2019-04-02 [PMID: 30940800] (Bioassay, Mouse)
• X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert Point mutations in the PDX1 transactivation domain impair human ?-cell development and function Mol Metab, 2019-03-20;0(0):. 2019-03-20 [PMID: 30930126] (Human)
• O Lyros, AK Lamprecht, L Nie, R Thieme, K Götzel, M Gasparri, G Haasler, P Rafiee, R Shaker, I Gockel Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett&#039;s associated esophageal adenocarcinoma Am J Cancer Res, 2019-02-01;9(2):330-346. 2019-02-01 [PMID: 30906632] (Bioassay, Human)
• P Shooshtari, A Helness, C Vadnais, N Brouwer, H Beauchemin, R Chen, H Bagci, FJT Staal, JF Coté, T Möröy Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes Nat Commun, 2019-03-20;10(1):1270. 2019-03-20 [PMID: 30894540] (Bioassay, Human)
• K Götzel, O Chemnitzer, L Maurer, A Dietrich, U Eichfeld, O Lyros, Y Moulla, S Niebisch, M Mehdorn, B Jansen-Win, M Vieth, A Hoffmeiste, I Gockel, R Thieme In-depth characterization of the Wnt-signaling/?-catenin pathway in an in vitro model of Barrett&#039;s sequence BMC Gastroenterol, 2019-03-06;19(1):38. 2019-03-06 [PMID: 30841855] (Bioassay, Human)
• T Colunga, M Hayworth, S Kre beta , DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 2019-03-05;26(10):2566-2579.e10. 2019-03-05 [PMID: 30840882] (Bioassay, Human)
• H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 2019-01-29;13(0):243-252. 2019-01-29 [PMID: 30828587] (Bioassay, Human)
• V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed Excess growth hormone suppresses DNA damage repair in epithelial cells JCI Insight, 2019-02-07;4(3):. 2019-02-07 [PMID: 30728323] (Bioassay, Human)
• X Yu, M Wang, J Wu, Q Han, X Zhang ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway J. Exp. Clin. Cancer Res., 2019-01-28;38(1):40. 2019-01-28 [PMID: 30691485] (Bioassay, Human)
• L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 2019-01-21;10(1):364. 2019-01-21 [PMID: 30664750] (Bioassay, Human)
• KE Worley, AS Chin, LQ Wan Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation Stem Cells Int, 2018-12-02;2018(0):1848605. 2018-12-02 [PMID: 30627170] (Bioassay, Human)
• C Bonamy, E Sechet, A Amiot, A Alam, M Mourez, L Fraisse, PJ Sansonetti, B Sperandio Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells Sci Rep, 2018-12-21;8(1):18043. 2018-12-21 [PMID: 30575780] (Bioassay, Human)
• A Ogorodniko, M Levin, S Tattikota, S Tokalov, M Hoque, D Scherzinge, F Marini, A Poetsch, H Binder, S Macher-Göp, HC Probst, B Tian, M Schaefer, KJ Lackner, F Westermann, S Danckwardt Transcriptome 3&#039;end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma Nat Commun, 2018-12-14;9(1):5331. 2018-12-14 [PMID: 30552333] (Bioassay, Human)
• BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 2018-12-12;0(0):e12844. 2018-12-12 [PMID: 30548452] (Bioassay, Mouse)
• J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family PLoS ONE, 2018-12-12;13(12):e0208110. 2018-12-12 [PMID: 30540809] (Bioassay, Human)
• T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells Cell Mol Gastroenterol Hepatol, 2018-09-14;7(1):73-91. 2018-09-14 [PMID: 30510992] (Bioassay, Human)
• R Diacou, Y Zhao, D Zheng, A Cvekl, W Liu Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation Cell Rep, 2018-11-27;25(9):2510-2523.e4. 2018-11-27 [PMID: 30485816] (Bioassay, Mouse)
• Q Peng, L Chen, W Wu, J Wang, X Zheng, Z Chen, Q Jiang, J Han, L Wei, L Wang, J Huang, J Ma EPH receptor A2 governs a feedback loop that activates Wnt/?-catenin signaling in gastric cancer Cell Death Dis, 2018-11-19;9(12):1146. 2018-11-19 [PMID: 30451837] (Bioassay, Human)
• K Jeon, D Kumar, AE Conway, K Park, R Jothi, AM Jetten GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors Stem Cells, 2018-12-02;0(0):. 2018-12-02 [PMID: 30376208] (ELISA (Standard), Human)
• H Ida, T Akiyama, K Ishiguro, SK Goparaju, Y Nakatake, N Chikazawa-, S Sato, H Kimura, Y Yokoyama, M Nagino, MSH Ko, SBH Ko Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors Stem Cell Res Ther, 2018-10-25;9(1):277. 2018-10-25 [PMID: 30359326] (Bioassay, Human)
• B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling Cell Rep, 2018-10-16;25(3):571-584.e5. 2018-10-16 [PMID: 30332639] (Bioassay, Human)
• E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3 Proc. Natl. Acad. Sci. U.S.A., 2018-10-01;0(0):. 2018-10-01 [PMID: 30275324] (Bioassay, Human)
• S Yamada, Y Kubo, D Yamazaki, Y Sekino, Y Nomura, S Yoshida, Y Kanda Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells Sci Rep, 2018-08-14;8(1):12155. 2018-08-14 [PMID: 30108368] (Bioassay, Human)
• E Magro-Lope, C Palmer, J Manso, I Liste, A Zambrano Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids Stem Cell Res Ther, 2018-07-11;9(1):186. 2018-07-11 [PMID: 29996941] (Bioassay, Human)
• Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X. 2017-12-29 [PMID: 29930984] (Bioassay, Human)
• Y Zhao, C Wang, C Wang, X Hong, J Miao, Y Liao, L Zhou, Y Liu An essential role for Wnt/?-catenin signaling in mediating hypertensive heart disease Sci Rep, 2018-06-12;8(1):8996. 2018-06-12 [PMID: 29895976] (Bioassay, Rat)
• M Russo, S Lamba, A Lorenzato, A Sogari, G Corti, G Rospo, B Mussolin, M Montone, L Lazzari, S Arena, D Oddo, M Linnebache, A Sartore-Bi, F Pietranton, S Siena, F Di Nicolan, A Bardelli Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies Nat Commun, 2018-06-12;9(1):2287. 2018-06-12 [PMID: 29895949] (Bioassay, Human)
• J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018-06-13;0(0):9636897187803. 2018-06-13 [PMID: 29895168] (Bioassay, Human)
• D Garnier, R Li, F Delbos, A Fourrier, C Collet, C Guguen-Gui, C Chesné, TH Nguyen Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system Sci Rep, 2018-05-29;8(1):8222. 2018-05-29 [PMID: 29844473] (Bioassay, Human)
• A Sarkar, A Mei, ACM Paquola, S Stern, C Bardy, JR Klug, S Kim, N Neshat, HJ Kim, M Ku, MN Shokhirev, DH Adamowicz, MC Marchetto, R Jappelli, JA Erwin, K Padmanabha, M Shtrahman, X Jin, FH Gage Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In�Vitro Cell Stem Cell, 2018-05-03;22(5):684-697.e9. 2018-05-03 [PMID: 29727680] (Bioassay, Human)
• BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao A20 regulates canonical wnt-signaling through an interaction with RIPK4 PLoS ONE, 2018-05-02;13(5):e0195893. 2018-05-02 [PMID: 29718933] (Bioassay, Human)
• HK Lee, EW Lee, J Seo, M Jeong, SH Lee, SY Kim, EH Jho, CH Choi, JY Chung, J Song Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/?-catenin signaling Oncogene, 2018-05-01;0(0):. 2018-05-01 [PMID: 29713058] (Bioassay, Human)
• M Amin, Y Kushida, S Wakao, M Kitada, K Tatsumi, M Dezawa Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype Cell Transplant, 2018-02-01;27(2):285-298. 2018-02-01 [PMID: 29637816] (Bioassay, Human)
• H He, F Du, Y He, Z Wei, C Meng, Y Xu, H Zhou, N Wang, XG Luo, W Ma, TC Zhang The Wnt-?-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells Oncotarget, 2018-01-04;9(20):15239-15251. 2018-01-04 [PMID: 29632640] (Bioassay, Human)
• XG Li, Z Wang, RQ Chen, HL Fu, CQ Gao, HC Yan, GX Xing, XQ Wang LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling Int J Mol Sci, 2018-03-30;19(4):. 2018-03-30 [PMID: 29601474] (Bioassay, Porcine)
• HJ Lee, J Li, RE Vickman, J Li, R Liu, A Durkes, BD Elzey, S Yue, X Liu, TL Ratliff, JX Cheng Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway Mol. Cancer Res., 2018-03-15;0(0):. 2018-03-15 [PMID: 29545473] (Bioassay, Human)
• S Condello, LE Sima, C Ivan, H Cardenas, GE Schiltz, RK Mishra, D Matei Tissue transglutaminase regulates interactions between ovarian cancer stem cells and the tumor niche Cancer Res., 2018-03-06;0(0):. 2018-03-06 [PMID: 29510995] (Bioassay, Human)
• M Szemes, A Greenhough, Z Melegh, S Malik, A Yuksel, D Catchpoole, K Gallacher, M Kollareddy, JH Park, K Malik Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma Neoplasia, 2018-03-03;20(4):335-350. 2018-03-03 [PMID: 29505958] (Bioassay, Human)
• S Kokabu, V Rosen BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling FEBS Open Bio, 2017-12-16;8(2):168-176. 2017-12-16 [PMID: 29435407] (Bioassay, Mouse)
• J Gillespie, RL Ross, C Corinaldes, F Esteves, E Derrett-Sm, MF McDermott, GM Doody, CP Denton, P Emery, F Del Galdo TGF? activation primes canonical Wnt signaling through the downregulation of AXIN2 Arthritis & rheumatology (Hoboken, N.J.), 2018-04-23;0(0):. 2018-04-23 [PMID: 29409120] (Cell Culture, Human)
• X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert Genome-wide analysis of PDX1 target genes in human pancreatic progenitors Mol Metab, 2018-01-31;0(0):. 2018-01-31 [PMID: 29396371] (Bioassay, Human)
• S Lamprecht, M Kaller, EM Schmidt, C Blaj, TS Schiergens, J Engel, A Jung, H Hermeking, TGP Grünewald, T Kirchner, D Horst PBX3 is part of an EMT regulatory network and indicates poor outcome in colorectal cancer Clin. Cancer Res., 2018-02-01;0(0):. 2018-02-01 [PMID: 29391352] (Stimulation, Human)
• AG Hawkins, V Basrur, F da Veiga L, E Pedersen, C Sperring, AI Nesvizhski, ER Lawlor The Ewing sarcoma secretome and its response to activation of Wnt/beta-catenin signaling Mol. Cell Proteomics, 2018-01-31;0(0):. 2018-01-31 [PMID: 29386236] (Human)
• Y Sui, Z Liu, SH Park, SE Thatcher, B Zhu, JP Fernandez, H Molina, PA Kern, C Zhou IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation JCI Insight, 2018-01-25;3(2):. 2018-01-25 [PMID: 29367460] (Bioassay, Mouse)
• Q Li, Q Wang, O Wang, K Shao, H Lin, Y Lei A simple and scalable hydrogel-based system for culturing protein-producing cells PLoS ONE, 2018-01-02;13(1):e0190364. 2018-01-02 [PMID: 29293594] (Bioassay, Human)
• DS Varghese, S Parween, MT Ardah, BS Emerald, SA Ansari Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro Stem Cells Int, 2017-09-24;2017(0):2451927. 2017-09-24 [PMID: 29147115] (Bioassay, Human)
• V Uribe-Etxe, J Luzuriaga, P García-Gal, A Agliano, F Unda, G Ibarretxe Notch/Wnt cross-signalling regulates stemness of dental pulp stem cells through expression of neural crest and core pluripotency factors Eur Cell Mater, 2017-11-01;34(0):249-270. 2017-11-01 [PMID: 29092089] (Bioassay, Human)
• SJ Zhao, YQ Jiang, NW Xu, Q Li, Q Zhang, SY Wang, J Li, YH Wang, YL Zhang, SH Jiang, YJ Wang, YJ Huang, XX Zhang, GA Tian, CC Zhang, YY Lv, M Dai, F Liu, R Zhang, D Zhou, ZG Zhang SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/?-catenin signaling through stabilization of the WNT-receptor complex Oncogene, 2017-10-30;0(0):. 2017-10-30 [PMID: 29084211] (Bioassay, Human)
• H Xiao, Y Zeng, Q Wang, S Wei, X Zhu A Novel Positive Feedback Loop Between NTSR1 and Wnt/?-Catenin Contributes to Tumor Growth of Glioblastoma Cell. Physiol. Biochem., 2017-10-24;43(5):2133-2142. 2017-10-24 [PMID: 29065410] (Cell Culture, Human)
• S Miura, A Suzuki Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming Cell Stem Cell, 2017-09-21;0(0):. 2017-09-21 [PMID: 28943029] (Bioassay, Human)
• N Yucer, M Holzapfel, T Jenkins Vo, L Lenaeus, L Ornelas, A Laury, D Sareen, R Barrett, BY Karlan, CN Svendsen Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium Sci Rep, 2017-09-06;7(1):10741. 2017-09-06 [PMID: 28878359] (Bioassay, Human)
• X Li, C Wang, G Zhang, M Liang, B Zhang AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells Mol Med Rep, 2017-08-18;0(0):. 2017-08-18 [PMID: 28849175] (Bioassay, Human)
• S Premarathn, M Murtaza, N Matigian, LA Jolly, SA Wood Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors Sci Rep, 2017-08-14;7(1):8109. 2017-08-14 [PMID: 28808228] (Bioassay, Human)
• Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid. Nutrients, 2017-08-10;0(0):2072-6643. 2017-08-10 [PMID: 28796175] (Cell Culture, Human)
• Y Kishimoto, B Ohkawara, T Sakai, M Ito, A Masuda, N Ishiguro, C Shukunami, D Docheva, K Ohno Wnt/?-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells PLoS ONE, 2017-07-27;12(7):e0182051. 2017-07-27 [PMID: 28750046] (Bioassay, Human)
• S Monteagudo, FMF Cornelis, C Aznar-Lope, P Yibmantasi, LA Guns, P Carmeliet, F Cailotto, RJ Lories DOT1L safeguards cartilage homeostasis and protects against osteoarthritis Nat Commun, 2017-06-19;8(0):15889. 2017-06-19 [PMID: 28627522] (Bioassay, Human)
• JG Camp, K Sekine, T Gerber, H Loeffler-W, H Binder, M Gac, S Kanton, J Kageyama, G Damm, D Seehofer, L Belicova, M Bickle, R Barsacchi, R Okuda, E Yoshizawa, M Kimura, H Ayabe, H Taniguchi, T Takebe, B Treutlein Multilineage communication regulates human liver bud development from pluripotency Nature, 2017-06-14;0(0):. 2017-06-14 [PMID: 28614297] (Bioassay, Human)
• S Zeng, AM Seifert, JQ Zhang, MJ Cavnar, TS Kim, VP Balachandr, JA Santamaria, NA Cohen, MJ Beckman, B Medina, F Rossi, MH Crawley, JK Loo, JH Maltbaek, P Besmer, CR Antonescu, RP DeMatteo Wnt/?-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor Mol. Cancer Ther., 2017-06-13;0(0):. 2017-06-13 [PMID: 28611108] (Bioassay, Human)
• ML Xu, CWC Bi, EYL Liu, TTX Dong, KWK Tsim Wnt3a Induces the Expression of Acetylcholinesterase during Osteoblast Differentiation via the Runx2 Transcription Factor J. Biol. Chem., 2017-06-12;0(0):. 2017-06-12 [PMID: 28607150] (Bioassay, Rat)
• H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura Establishment of a refined culture method for rat colon organoids Biochem. Biophys. Res. Commun., 2017-05-27;0(0):. 2017-05-27 [PMID: 28559141] (Bioassay, Rat)
• XH Jiang, YT Xie, YP Cai, J Ren, T Ma Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/?-catenin pathway BMC Microbiol., 2017-05-25;17(1):124. 2017-05-25 [PMID: 28545480] (Bioassay, Human)
• B Lucendo-Vi, P Filis, MJ Swortwood, MA Huestis, J Meseguer-R, K Cameron, JP Iredale, PJ O'Shaughne, PA Fowler, DC Hay Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells Arch. Toxicol., 2017-05-16;0(0):. 2017-05-16 [PMID: 28510779] (Bioassay, Human)
• Q Gu, J Wang, L Wang, ZX Liu, WW Zhu, YQ Tan, WF Han, J Wu, CJ Feng, JH Fang, L Liu, L Wang, W Li, XY Zhao, BY Hu, J Hao, Q Zhou Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations Stem Cell Reports, 2017-05-11;0(0):. 2017-05-11 [PMID: 28506532] (Bioassay, Human)
• I Savvidou, T Khong, A Cuddihy, C McLean, S Horrigan, A Spencer Beta-catenin inhibitor BC2059 is efficacious as monotherapy or in combination with proteasome inhibitor bortezomib in multiple myeloma Mol. Cancer Ther., 2017-05-12;0(0):. 2017-05-12 [PMID: 28500235] (Bioassay, Human)
• PC Sanchez-Di, JC Chang, ES Moses, T Dao, Y Chen, JY Hung Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma PLoS ONE, 2017-05-04;12(5):e0176879. 2017-05-04 [PMID: 28472177] (Bioassay, Human)
• CY Janda, LT Dang, C You, J Chang, W de Lau, ZA Zhong, KS Yan, O Marecic, D Siepe, X Li, JD Moody, BO Williams, H Clevers, J Piehler, D Baker, CJ Kuo, KC Garcia Surrogate Wnt agonists that phenocopy canonical Wnt and ?-catenin signalling Nature, 2017-05-03;0(0):. 2017-05-03 [PMID: 28467818] (Bioassay, Human)
• K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System Stem Cell Reports, 2017-04-27;0(0):. 2017-04-27 [PMID: 28457888] (Bioassay, Human)
• JA Heslop, R Kia, CS Pridgeon, RL Sison-Youn, T Liloglou, M Elmasry, SW Fenwick, JS Mills, NR Kitteringh, CE Goldring, BK Park Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells Stem Cells Transl Med, 2017-05-01;6(5):1321-1331. 2017-05-01 [PMID: 28456008] (Bioassay, Human)
• T Nakamura, T Hosoyama, J Murakami, M Samura, K Ueno, H Kurazumi, R Suzuki, A Mikamo, K Hamano Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells Biochem. Biophys. Res. Commun., 2017-04-21;0(0):. 2017-04-21 [PMID: 28435069] (Bioassay, Human)
• F Ou, K Su, J Sun, W Liao, Y Yao, Y Zheng, Z Zhang The LncRNA ZBED3-AS1 induces chondrogenesis of human synovial fluid mesenchymal stem cells Biochem. Biophys. Res. Commun., 2017-04-18;487(2):457-463. 2017-04-18 [PMID: 28431932] (Bioassay, Human)
• JJ Kathiriya, N Nakra, J Nixon, PS Patel, V Vaghasiya, A Alhassani, Z Tian, D Allen-Gips, V Davé Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis Cell Death Discov, 2017-04-10;3(0):17010. 2017-04-10 [PMID: 28417017] (Bioassay, Human)
• LA Ahrens, D Vonwil, J Christense, VP Shastri Gelatin device for the delivery of growth factors involved in endochondral ossification PLoS ONE, 2017-04-05;12(4):e0175095. 2017-04-05 [PMID: 28380024] (Bioassay, Human)
• H Montacir, N Freyer, F Knoespel, T Urbaniak, T Dedova, M Berger, G Damm, R Tauber, K Zeilinger, V Blanchard The N-glycome of embryonic stem cells and thereof differentiated hepatic cells Chembiochem, 2017-05-15;0(0):. 2017-05-15 [PMID: 28370937] (Bioassay, Human)
• DM Velázquez, MC Castañeda-, M Robles-Flo Dishevelled stability is positively regulated by PKC?-mediated phosphorylation induced by Wnt agonists Cell. Signal., 2017-03-31;35(0):107-117. 2017-03-31 [PMID: 28366812] (Bioassay, Human)
• KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Human)
• J Messéant, J Ezan, P Delers, K Glebov, C Marchiol, F Lager, G Renault, F Tissir, M Montcouqui, N Sans, C Legay, L Strochlic Wnts contribute to neuromuscular junction formation through distinct signaling pathways Development, 2017-03-27;0(0):. 2017-03-27 [PMID: 28348167] (Bioassay, Mouse)
• K Minegishi, M Hashimoto, R Ajima, K Takaoka, K Shinohara, Y Ikawa, H Nishimura, AP McMahon, K Willert, Y Okada, H Sasaki, D Shi, T Fujimori, T Ohtsuka, Y Igarashi, TP Yamaguchi, A Shimono, H Shiratori, H Hamada A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking Dev. Cell, 2017-03-13;40(5):439-452.e4. 2017-03-13 [PMID: 28292423] (Bioassay, Mouse)
• A Asai, E Aihara, C Watson, R Mourya, T Mizuochi, P Shivakumar, K Phelan, C Mayhew, M Helmrath, T Takebe, J Wells, JA Bezerra Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells Development, 2017-03-15;144(6):1056-1064. 2017-03-15 [PMID: 28275009] (Bioassay, Human)
• J Yang, Y Wang, T Zhou, LY Wong, XY Tian, X Hong, WH Lai, KW Au, R Wei, Y Liu, LH Cheng, G Liang, Z Huang, W Fan, P Zhao, X Wang, DP Ibañez, Z Luo, Y Li, X Zhong, S Chen, D Wang, L Li, L Lai, B Qin, X Bao, AP Hutchins, CW Siu, Y Huang, MA Esteban, HF Tse Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells Stem Cell Reports, 2017-03-02;0(0):. 2017-03-02 [PMID: 28262545] (Bioassay, Human)
• A Persad, G Venkateswa, L Hao, ME Garcia, J Yoon, J Sidhu, S Persad Active ?-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A Genes Cancer, 2016-11-01;7(12):368-382. 2016-11-01 [PMID: 28191283] (Bioassay, Human)
• N Arora, J Imran Also, JW Guggenheim, M Mak, J Munera, JM Wells, RD Kamm, HH Asada, SY Shvartsman, LG Griffith A process engineering approach to increase organoid yield Development, 2017-02-07;144(6):1128-1136. 2017-02-07 [PMID: 28174251] (Bioassay, Human)
• J Jang, Y Jung, S Chae, SI Chung, SM Kim, Y Yoon WNT/?-catenin pathway modulates the TNF-?-induced inflammatory response in bronchial epithelial cells Biochem. Biophys. Res. Commun, 2017-01-28;0(0):. 2017-01-28 [PMID: 28137581] (Bioassay, Human)
• Z Wen, T Pan, S Yang, J Liu, H Tao, Y Zhao, D Xu, W Shao, J Wu, X Liu, Y Wang, J Mao, Y Zhu Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting ROR? Mol. Cancer, 2017-01-31;16(1):20. 2017-01-31 [PMID: 28137278] (Bioassay, Human)
• J Jang, Y Jung, Y Kim, EH Jho, Y Yoon LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974 Sci Rep, 2017-01-27;7(0):41612. 2017-01-27 [PMID: 28128299] (Bioassay, Human)
• Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Sci Rep, 2017-01-25;7(0):41238. 2017-01-25 [PMID: 28120901] (Bioassay, Human)
• IT Cho, Y Lim, JA Golden, G Cho Aristaless Related Homeobox (ARX) Interacts with ?-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling PLoS ONE, 2017-01-19;12(1):e0170282. 2017-01-19 [PMID: 28103279] (Bioassay, Human)
• L J Spicer G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99. 2016-12-11 [PMID: 28040605] (Bioassay, Bovine)
• Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins Proc. Natl. Acad. Sci. U.S.A, 2016-12-27;0(0):. 2016-12-27 [PMID: 28028233] (Bioassay, Human)
• Hoeke A Baarsma Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD J. Exp. Med, 2016-12-15;0(0):. 2016-12-15 [PMID: 27979969] (Bioassay, Mouse)
• Gui-Li Huang Oncogenic retinoic acid receptor ? promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3?/?-catenin signaling Cancer Lett, 2016-12-05;388(0):118-129. 2016-12-05 [PMID: 27932034] (Bioassay, Human)
• Elena Neumann Expression of adipokines in osteoarthritis osteophytes and their effect on osteoblasts Matrix Biol., 2016-11-22;0(0):. 2016-11-22 [PMID: 27884778] (Bioassay, Human)
• Quantifying ?-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells Elife, 2016-11-23;5(0):. 2016-11-23 [PMID: 27879202] (Bioassay, Mouse)
• Ronald A DePinho Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth Cell, 2016-11-17;167(5):1281-1295.e18. 2016-11-17 [PMID: 27863244] (Bioassay, Human)
• Richard P Phipps The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation: Implications for Thyroid Eye Disease Am. J. Pathol., 2016-11-11;0(0):. 2016-11-11 [PMID: 27842700] (Bioassay, Human)
• PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells Sci Rep, 2016-11-09;6(0):36795. 2016-11-09 [PMID: 27827428] (Bioassay, Human)
• Karthikeyan Mythreye Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling J. Biol. Chem., 2016-10-26;291(49):25716-25728. 2016-10-26 [PMID: 27784788] (Bioassay, Human)
• ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation Stem Cell Res, 2016-08-04;17(2):222-227. 2016-08-04 [PMID: 27591478] (Bioassay, Human)
• Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2 Cancer Res, 2016-08-30;0(0):. 2016-08-30 [PMID: 27578003] (Bioassay, Human)
• TNIK inhibition abrogates colorectal cancer stemness Nat Commun, 2016-08-26;7(0):12586. 2016-08-26 [PMID: 27562646] (Bioassay, Human)
• Anthelmintic niclosamide disrupts the interplay of p65 and FOXM1/?-catenin and eradicates leukemia stem cells in chronic myelogenous leukemia Clin Cancer Res, 2016-08-04;0(0):. 2016-08-04 [PMID: 27492973] (Bioassay, Human)
• The AKAP GSKIP regulates beta-catenin through both its interactions with PKA and GSK3beta J Biol Chem, 2016-08-02;0(0):. 2016-08-02 [PMID: 27484798] (Bioassay, Human)
• Growth hormone is permissive for neoplastic colon growth Proc Natl Acad Sci USA, 2016-05-25;0(0):. 2016-05-25 [PMID: 27226307] (Bioassay, Human)
• Activation of endothelial ?-catenin signaling induces heart failure Sci Rep, 2016-05-05;6(0):25009. 2016-05-05 [PMID: 27146149] (Bioassay, Human)
• Junhua Wang, Yunxia Tao, Zichuan Ping, Wen Zhang, Xuanyang Hu, Yijun Wang, Liangliang Wang, Jiawei Shi, Xiexing Wu, Huilin Yang, Yaozeng Xu, Dechun Geng Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/?-catenin signaling pathway in vivo and in vitro. Scientific Reports, 2016-03-31;0(0):2045-2322. 2016-03-31 [PMID: 27029606] (Bioassay, Mouse)
• Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/?-catenin defects in neuronal cholesterol synthesis phenotypes Nat. Med., 2016-03-21;22(4):388-96. 2016-03-21 [PMID: 26998835] (Bioassay, Human)
• Yasuhiro Ikeda Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration Stem Cells Transl Med, 2016-03-17;5(5):694-702. 2016-03-17 [PMID: 26987352] (Bioassay, Human)
• Henry C, Llamosas E, Knipprath-Meszaros A, Schoetzau A, Obermann E, Fuenfschilling M, Caduff R, Fink D, Hacker N, Ward R, Heinzelmann-Schwarz V, Ford C Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion. Oncotarget, 2015-11-24;6(37):40310-26. 2015-11-24 [PMID: 26515598] (Bioassay, Human)
• Tamminen K, Balboa D, Toivonen S, Pakarinen M, Wiener Z, Alitalo K, Otonkoski T Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. PLoS ONE, 2015-07-31;10(7):e0134551. 2015-07-31 [PMID: 26230325] (Bioassay, Human)
• Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A DNA methylation directs functional maturation of pancreatic beta cells. J Clin Invest, 2015-06-22;125(7):2851-60. 2015-06-22 [PMID: 26098213] (Bioassay, Human)
• Zanni R, Galvez-Llompart M, Morell C, Rodriguez-Henche N, Diaz-Laviada I, Recio-Iglesias M, Garcia-Domenech R, Galvez J Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors. PLoS ONE, 2015-04-24;10(4):e0124244. 2015-04-24 [PMID: 25910265] (Bioassay, Human)
• Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy M, Rahman R, Ma J, Xia L, Chen H Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun, 2015-03-16;6(0):6380. 2015-03-16 [PMID: 25871009] (Bioassay, Human)
• Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, Deng Z, Blanchette N, Arvedson T, Miranti C, Babitt J, Lin H, Peehl D, Torti F, Torti S Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res, 2015-04-09;75(11):2254-63. 2015-04-09 [PMID: 25858146] (Bioassay, Human)
• Maubant S, Tesson B, Maire V, Ye M, Rigaill G, Gentien D, Cruzalegui F, Tucker G, Roman-Roman S, Dubois T Transcriptome analysis of wnt3a-treated triple-negative breast cancer cells. PLoS ONE, 2015-04-07;10(4):e0122333. 2015-04-07 [PMID: 25848952] (Bioassay, Human)
• Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development, 2015-03-26;142(8):1528-41. 2015-03-26 [PMID: 25813541] (Bioassay, Human)
• Kuhnl A, Valk P, Sanders M, Ivey A, Hills R, Mills K, Gale R, Kaiser M, Dillon R, Joannides M, Gilkes A, Haferlach T, Schnittger S, Duprez E, Linch D, Delwel R, Lowenberg B, Baldus C, Solomon E, Burnett A, Grimwade D Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Blood, 2015-03-24;125(19):2985-94. 2015-03-24 [PMID: 25805812] (Bioassay, Human)
• Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells. PLoS ONE, 2015-03-16;10(3):e0119904. 2015-03-16 [PMID: 25774684] (Bioassay, Human)
• Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS ONE, 2015-02-23;10(2):e0118670. 2015-02-23 [PMID: 25706534] (Bioassay, Human)
• Tsankov , Alexande, Gu , Hongcang, Akopian , Veronika, Ziller , Michael, Donaghey , Julie, Amit , Ido, Gnirke , Andreas, Meissner , Alexande Transcription factor binding dynamics during human ES cell differentiation. Nature, 2015-02-19;518(7539):344-9. 2015-02-19 [PMID: 25693565] (Bioassay, Human)
• James M, Howells L, Karmokar A, Higgins J, Greaves P, Cai H, Dennison A, Metcalfe M, Garcea G, Lloyd D, Berry D, Steward W, Brown K Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note. PLoS ONE, 2015-02-06;10(2):e0117776. 2015-02-06 [PMID: 25658706] (Bioassay, Human)
• Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 2015-02-05;10(3):413-25. 2015-02-05 [PMID: 25654758] (Bioassay, Human)
• Wong , Amy P, Chin , Stephani, Xia , Sunny, Garner , Jodi, Bear , Christin, Rossant , Janet Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc, 2015-02-05;10(3):363-81. 2015-02-05 [PMID: 25654755] (Bioassay, Human)
• Yu N, Kakunda M, Pham V, Lill J, Du P, Wongchenko M, Yan Y, Firestein R, Huang X HSP105 recruits protein phosphatase 2A to dephosphorylate beta-catenin. Mol Cell Biol, 2015-02-02;35(8):1390-400. 2015-02-02 [PMID: 25645927] (Bioassay, Human)
• Peng H, Park J, Katsnelson J, Kaplan N, Yang W, Getsios S, Lavker R microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics. Stem Cells, 2015-05-01;33(5):1642-56. 2015-05-01 [PMID: 25639731] (Bioassay, Human)
• Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, Huang S Tumour suppressor TRIM33 targets nuclear beta-catenin degradation. Nat Commun, 2015-02-02;6(0):6156. 2015-02-02 [PMID: 25639486] (Bioassay, Human)
• Grigson E, Ozerova M, Pisklakova A, Liu H, Sullivan D, Nefedova Y Canonical Wnt pathway inhibitor ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent manner. PLoS ONE, 2015-01-30;10(1):e0117693. 2015-01-30 [PMID: 25635944] (Bioassay, Human)
• Huang T, Li L, Moalim-Nour L, Jia D, Bai J, Yao Z, Bennett S, Figeys D, Wang L A Regulatory Network Involving beta-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling. Stem Cells, 2015-05-01;33(5):1419-33. 2015-05-01 [PMID: 25538040] (Bioassay, Human)
• Viale-Bouroncle S, Klingelhoffer C, Ettl T, Reichert T, Morsczeck C A protein kinase A (PKA)/beta-catenin pathway sustains the BMP2/DLX3-induced osteogenic differentiation in dental follicle cells (DFCs). Cell Signal, 2014-12-19;27(3):598-605. 2014-12-19 [PMID: 25530217] (Bioassay, Human)
• Handorf A, Chamberlain C, Li W Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev, 2015-01-26;24(8):995-1007. 2015-01-26 [PMID: 25519748] (Bioassay, Human)
• Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol, 2014-11-10;33(1):89-96. 2014-11-10 [PMID: 25383599] (Bioassay, Human)
• Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang A, Niklason L Tissue-engineered vascular grafts created from human induced pluripotent stem cells. Stem Cells Transl Med, 2014-11-05;3(12):1535-43. 2014-11-05 [PMID: 25378654] (Bioassay, Human)
• Hirata , Naoya, Yamada , Shigeru, Shoda , Takuji, Kurihara , Masaaki, Sekino , Yuko, Kanda , Yasunari Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat Commun, 2014-09-25;5(0):4806. 2014-09-25 [PMID: 25254944] (Bioassay, Human)
• Jabaji Z, Brinkley G, Khalil H, Sears C, Lei N, Lewis M, Stelzner M, Martin M, Dunn J Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium. PLoS ONE, 2014-09-15;9(9):e107814. 2014-09-15 [PMID: 25222024] (Bioassay, Human)
• Williams K, Bundred N, Landberg G, Clarke R, Farnie G Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy. Stem Cells, 2015-02-01;33(2):327-41. 2015-02-01 [PMID: 25187396] (Bioassay, Human)
• Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, Hwang S, Renshaw P Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS ONE, 2014-08-29;9(8):e104937. 2014-08-29 [PMID: 25170755] (Bioassay, Human)
• Hwang Y, Suk S, Shih Y, Seo T, Du B, Xie Y, Li Z, Varghese S WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. Sci Rep, 2014-08-01;4(0):5916. 2014-08-01 [PMID: 25084050] (Bioassay, Human)
• Lee J, Heur M Interleukin-1beta-induced Wnt5a enhances human corneal endothelial cell migration through regulation of Cdc42 and RhoA. Mol Cell Biol, 2014-07-14;34(18):3535-45. 2014-07-14 [PMID: 25022753] (Bioassay, Human)
• Ao , Ying, Mich-Basso , Jocelyn, Lin , Bo, Yang , Lei High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells. PLoS ONE, 2014-06-20;9(6):e100417. 2014-06-20 [PMID: 24949734] (Bioassay, Porcine)
• Cecchelli R, Aday S, Sevin E, Almeida C, Culot M, Dehouck L, Coisne C, Engelhardt B, Dehouck M, Ferreira L A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells. PLoS ONE, 2014-06-17;9(6):e99733. 2014-06-17 [PMID: 24936790] (Bioassay, Human)
• Skoczek D, Walczysko P, Horn N, Parris A, Clare S, Williams M, Sobolewski A Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium. J Immunol, 2014-06-06;193(1):439-51. 2014-06-06 [PMID: 24907348] (Bioassay, Human)
• Pethe , Prasad, Nagvenkar , Punam, Bhartiya , Deepa Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol, 2014-05-24;15(0):18. 2014-05-24 [PMID: 24885493] (Bioassay, Human)
• Kilander M, Dahlstrom J, Schulte G Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity. Cell Signal, 2014-05-27;26(9):1943-9. 2014-05-27 [PMID: 24873871] (Bioassay, Human)
• Jin R, Liu W, Menezes S, Yue F, Zheng M, Kovacevic Z, Richardson D The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4. J Cell Sci, 2014-05-14;127(0):3116-30. 2014-05-14 [PMID: 24829151] (Bioassay, Human)
• Peng X, Yang L, Chang H, Dai G, Wang F, Duan X, Guo L, Zhang Y, Chen G Wnt/beta-catenin signaling regulates the proliferation and differentiation of mesenchymal progenitor cells through the p53 pathway. PLoS ONE, 2014-05-12;9(5):e97283. 2014-05-12 [PMID: 24819053] (Bioassay, Human)
• Hinton A, Hunter S, Afrikanova I, Jones G, Lopez A, Fogel G, Hayek A, King C sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells, 2014-09-01;32(9):2360-72. 2014-09-01 [PMID: 24805944] (Bioassay, Human)
• Fuerer C, Nostro M, Constam D Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation. J Biol Chem, 2014-05-05;289(25):17854-71. 2014-05-05 [PMID: 24798330] (Bioassay, Human)
• Kang , Minyong, Kim , Hyeon Ho, Han , Yong-Mah Generation of bladder urothelium from human pluripotent stem cells under chemically defined serum- and feeder-free system. Int J Mol Sci, 2014-04-25;15(5):7139-57. 2014-04-25 [PMID: 24776760] (Bioassay, Human)
• Hillesheim A, Nordhoff C, Boergeling Y, Ludwig S, Wixler V beta-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-kappaB signaling. Cell Commun Signal, 2014-04-26;12(0):29. 2014-04-26 [PMID: 24767605] (Bioassay, Human)
• Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer, 2014-04-26;13(0):88. 2014-04-26 [PMID: 24766647] (Bioassay, Human)
• Tsai T, Shih S, Ho T, Ma H, Liu M, Chen S, Tsao Y Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor. PLoS ONE, 2014-04-24;9(4):e95443. 2014-04-24 [PMID: 24763086] (Bioassay, Rat)
• Emmrich S, Rasche M, Schoning J, Reimer C, Keihani S, Maroz A, Xie Y, Li Z, Schambach A, Reinhardt D, Klusmann J miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFbeta and Wnt signaling. Genes Dev, 2014-04-15;28(8):858-74. 2014-04-15 [PMID: 24736844] (Bioassay, Human)
• Kang , Minyong, Han , Yong-Mah Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system. PLoS ONE, 2014-04-11;9(4):e94888. 2014-04-11 [PMID: 24728509] (Bioassay, Human)
• Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. PLoS ONE, 2014-04-07;9(4):e92273. 2014-04-07 [PMID: 24710173] (Bioassay, Human)
• Chen E, DeRan M, Ignatius M, Grandinetti K, Clagg R, McCarthy K, Lobbardi R, Brockmann J, Keller C, Wu X, Langenau D Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A, 2014-03-24;111(14):5349-54. 2014-03-24 [PMID: 24706870] (Bioassay, Human)
• Cnossen W, te Morsche R, Hoischen A, Gilissen C, Chrispijn M, Venselaar H, Mehdi S, Bergmann C, Veltman J, Drenth J Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Proc Natl Acad Sci U S A, 2014-03-24;111(14):5343-8. 2014-03-24 [PMID: 24706814] (Bioassay, Human)
• Carmon K, Gong X, Yi J, Thomas A, Liu Q RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A, 2014-03-17;111(13):E1221-9. 2014-03-17 [PMID: 24639526] (Bioassay, Human)
• Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 2014-03-06;14(3):342-56. 2014-03-06 [PMID: 24607406] (Bioassay, Human)
• Meinhardt G, Haider S, Haslinger P, Proestling K, Fiala C, Pollheimer J, Knofler M Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology, 2014-02-26;155(5):1908-20. 2014-02-26 [PMID: 24605829] (Bioassay, Human)
• Guezguez A, Pare F, Benoit Y, Basora N, Beaulieu J Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res, 2014-02-15;322(2):355-64. 2014-02-15 [PMID: 24534551] (Bioassay, Human)
• Lin , I-Ying, Chiu , Feng-Lan, Yeang , Chen-Hsi, Chen , Hsin-Fu, Chuang , Ching-Yu, Yang , Shii-Yi, Hou , Pei-Shan, Sintupisut , Nardnisa, Ho , Hong-Ner, Kuo , Hung-Chi, Lin , Kuo-I Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports, 2014-01-23;2(2):189-204. 2014-01-23 [PMID: 24527393] (Bioassay, Human)
• Wu C, Qiu S, Lu L, Zou J, Li W, Wang O, Zhao H, Wang H, Tang J, Chen L, Xu T, Sun Z, Liao W, Luo G, Lu X RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer. Nat Commun, 2014-01-01;5(0):3149. 2014-01-01 [PMID: 24476626] (Bioassay, Human)
• van den Bosch M, Blom A, van Lent P, van Beuningen H, Blaney Davidson E, van der Kraan P, van den Berg W Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell Signal, 2014-01-23;26(5):951-8. 2014-01-23 [PMID: 24463008] (Bioassay, Human)
• Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah S, Graf T, Broccoli V, Di Croce L Zrf1 is required to establish and maintain neural progenitor identity. Genes Dev, 2014-01-15;28(2):182-97. 2014-01-15 [PMID: 24449271] (Bioassay, Human)
• Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, Pourasgari F, Hajarizadeh A, Soleimani M, Nabiuni M, Khorramizadeh M Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells. Exp Cell Res, 2014-01-13;322(1):51-61. 2014-01-13 [PMID: 24434355] (Bioassay, Human)
• Dhamdhere , Girija R, Fang , Mark Y, Jiang , Jie, Lee , Katherin, Cheng , Du, Olveda , Rebecca, Liu , Bo, Mulligan , Kimberle, Carlson , Jeffery, Ransom , Ryan C, Weis , William, Helms , Jill A Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS ONE, 2014-01-06;9(1):e83650. 2014-01-06 [PMID: 24400074] (Bioassay, Human)
• Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells. Stem Cells Transl Med, 2013-12-27;3(3):277-89. 2013-12-27 [PMID: 24375542] (Bioassay, Human)
• Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol, 2013-12-19;25(6):1211-25. 2013-12-19 [PMID: 24357672] (Bioassay, Human)
• Hannan , Nicholas, Fordham , Robert P, Syed , Yasir A, Moignard , Victoria, Berry , Andrew, Bautista , Ruben, Hanley , Neil A, Jensen , Kim B, Vallier , Ludovic Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 2013-10-10;1(4):293-306. 2013-10-10 [PMID: 24319665] (Bioassay, Human)
• Listerman I, Gazzaniga F, Blackburn E An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. Mol Cell Biol, 2013-11-11;34(2):280-9. 2013-11-11 [PMID: 24216762] (Bioassay, Human)
• Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H IQGAP1 protein regulates nuclear localization of beta-catenin via importin-beta5 protein in Wnt signaling. J Biol Chem, 2013-11-06;288(51):36351-60. 2013-11-06 [PMID: 24196961] (Cell Culture, Human)
• Thrasivoulou C, Millar M, Ahmed A Activation of intracellular calcium by multiple Wnt ligands and translocation of beta-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/beta-catenin pathways. J Biol Chem, 2013-10-24;288(50):35651-9. 2013-10-24 [PMID: 24158438] (Bioassay, Human)
• Jiang Y, Dai J, Zhang H, Sottnik J, Keller J, Escott K, Sanganee H, Yao Z, McCauley L, Keller E Activation of the Wnt pathway through AR79, a GSK3beta inhibitor, promotes prostate cancer growth in soft tissue and bone. Mol Cancer Res, 2013-10-02;11(12):1597-610. 2013-10-02 [PMID: 24088787] (Bioassay, Human)
• Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells. Stem Cells Dev, 2013-11-16;23(4):372-9. 2013-11-16 [PMID: 24083371] (Bioassay, Human)
• Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells, 2013-11-01;31(11):2432-42. 2013-11-01 [PMID: 23897760] (Bioassay, Human)
• Rasmussen N, Wright T, Brooks S, Hacker K, Debebe Z, Sendor A, Walker M, Major M, Green J, Wahl G, Rathmell W Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem, 2013-07-26;288(36):26301-10. 2013-07-26 [PMID: 23893409] (Bioassay, Human)
• Loh Y, Hedditch E, Baker L, Jary E, Ward R, Ford C The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer, 2013-04-02;13(0):174. 2013-04-02 [PMID: 23547709] (Bioassay, Human)
• Hernandez-Maqueda J, Luna-Ulloa L, Santoyo-Ramos P, Castaneda-Patlan M, Robles-Flores M Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines. PLoS ONE, 2013-03-08;8(3):e58540. 2013-03-08 [PMID: 23520519] (Bioassay, Human)
• Greer Y, Fields A, Brown A, Rubin J Atypical protein kinase Ciota is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem, 2013-02-08;288(13):9438-46. 2013-02-08 [PMID: 23396968] (Bioassay, Human)
• Tahir S, Yang G, Goltsov A, Song K, Ren C, Wang J, Chang W, Thompson T Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer. Cancer Res, 2013-01-09;73(6):1900-11. 2013-01-09 [PMID: 23302227] (Bioassay, Human)
• Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2012-11-27;21(1):228-39. 2012-11-27 [PMID: 23183535] (Bioassay, Human)
• Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal, 2012-09-27;25(1):178-89. 2012-09-27 [PMID: 23022962] (Bioassay, Human, Mouse)
• Sui L, Mfopou J, Geens M, Sermon K, Bouwens L FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun, 2012-08-29;426(3):380-5. 2012-08-29 [PMID: 22960178] (Bioassay, Human)
• Aad , Pauline, Echternkamp , Sherrill, Sypherd , David D, Schreiber , Nicole B, Spicer , Leon J The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod, 2012-10-04;87(4):79. 2012-10-04 [PMID: 22811575] (Bioassay, Bovine)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Cohen E, Miller M, Wang Z, Moon R, Morrisey E Wnt5a and Wnt11 are essential for second heart field progenitor development. Development, 2012-06-01;139(11):1931-40. 2012-06-01 [PMID: 22569553] (Bioassay, Mouse)
• Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol, 2012-03-01;20(0):1H.51. 2012-03-01 [PMID: 22415839] (Bioassay, Human)
• Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant, 2011-12-21;21(6):1321-39. 2011-12-21 [PMID: 22195604] (Cell Culture, Human)
• Ichii , Michiko, Frank , Mark Bar, Iozzo , Renato V, Kincade , Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2011-11-23;119(7):1683-92. 2011-11-23 [PMID: 22117039] (Bioassay, Human)
• Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J. Bone Miner. Res., 2011-09-01;26(9):2082-95. 2011-09-01 [PMID: 21638320] (Bioassay, Human)
• Spence JR, Mayhew CN, Rankin SA Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 2010-12-12;470(7332):105-9. 2010-12-12 [PMID: 21151107] (Bioassay, Human)
• Kohler EE, Cowan CE, Chatterjee I NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood, 2010-11-30;117(5):1761-9. 2010-11-30 [PMID: 21119109] (Bioassay, Human)
• Gudjonsson JE, Johnston A, Stoll SW Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 2010-04-08;130(7):1849-59. 2010-04-08 [PMID: 20376066] (Bioassay, Human)
• Liu G, Vijayakumar S, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson SA Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J. Cell Biol., 2009-04-06;185(1):67-75. 2009-04-06 [PMID: 19349579] (Bioassay, Human)

Bioinformatics

• Gene Symbol: WNT3A
• Uniprot:
  • NP_149122(Human)