Recombinant Human Wnt-3a Protein

Recombinant Human Wnt-3a (Catalog # 5036-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The ED50 is 1.7-fold better with more than twice the maximum response compared to the top competitor's Wnt-3a.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human Wnt-3a Protein Summary

• Details of Functionality: Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED₅₀ for this effect is 5-25 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED₅₀ for this effect is <500 ng/mL. Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
  Optimal concentrations should be determined by each laboratory for each application.
• Source: Chinese Hamster Ovary cell line, CHO-derived human Wnt-3a protein
  Ser19-Lys352
• Accession #: NP_149122
• N-terminal Sequence: Ser19
• Protein/Peptide Type: Recombinant Proteins
• Gene: WNT3A
• Purity: >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Theoretical MW: 37.4 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• SDS-PAGE: 40 kDa, reducing conditions

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
• Purity: >75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Wnt-3a Protein

• MGC119418
• MGC119419
• MGC119420
• protein Wnt-3a
• wingless-type MMTV integration site family, member 3A
• Wnt3a
• Wnt-3a

Background

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Human Wnt-3a shares 96% amino acid (aa) identity with mouse mouse, bovine and canine Wnt-3a, and 89%, 86% and 84% aa identity with chicken, Xenopus and zebrafish Wnt-3a, respectively. It also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13, 14).

1. Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864.
2. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880.
3. Korinek, V. et al. (1997) Science 275:1784.
4. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100.
5. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267.
6. Takada, R. et al. (2006) Dev. Cell 11:791.
7. Komekado, H. (2007) Genes Cells 12:521.
8. Dunty Jr. W. C. et al. (2008) Development 135:85.
9. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27.
10. Lee, S. M. et al. (2000) Development 127:457.
11. Takada, S. et al. (1994) Genes Dev. 8:174.
12. Willert, K. et al. (2003) Nature 423:6938.
13. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970.
14. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.

Publications for Wnt-3a (5036-WN)(210)

Publications using 5036-WN

• P Kozielewic, A Turku, CF Bowin, J Petersen, J Valnohova, MCA Cañizal, Y Ono, A Inoue, C Hoffmann, G Schulte Structural insight into small molecule action on Frizzleds Nat Commun, 2020;11(1):414. 2020 [PMID: 31964872] (Cell Culture, Human)
• KH Grinnemo, M Löfling, L Nathanson, R Baumgartne, DFJ Ketelhuth, V Beljanski, LC Davies, C Österholm Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells Stem Cell Res Ther, 2019;10(1):371. 2019 [PMID: 31801632] (Bioassay, Human)
• AP Singh, YH Hung, MT Shanahan, M Kanke, A Bonfini, MK Dame, M Biraud, BCE Peck, OO Oyesola, JM Freund, RL Cubitt, EG Curry, LM Gonzalez, GA Bewick, ED Tait-Wojno, NA Kurpios, S Ding, JR Spence, CM Dekaney, N Buchon, P Sethupathy Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner Cell Mol Gastroenterol Hepatol, 2019;0(0):. 2019 [PMID: 31756561] (Tissue Culture, Porcine)
• Z Ye, S Mittag, M Schmidt, A Simm, R Horstkorte, O Huber Wnt Glycation Inhibits Canonical Signaling Cells, 2019;8(11):. 2019 [PMID: 31731544] (Cell Culture, Human)
• R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Nat Commun, 2019;10(1):5016. 2019 [PMID: 31676788] (Cell Culture, Human)
• RR Stine, AP Sakers, T TeSlaa, M Kissig, ZE Stine, CW Kwon, L Cheng, HW Lim, KH Kaestner, JD Rabinowitz, P Seale PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism Cell Stem Cell, 2019;0(0):. 2019 [PMID: 31564549] (Bioassay, Mouse)
• V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure Nat Commun, 2019;10(1):4161. 2019 [PMID: 31551422] (Bioassay, Human)
• F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore In vitro metabolic zonation through oxygen gradient on a chip Sci Rep, 2019;9(1):13557. 2019 [PMID: 31537830] (Bioassay, Human)
• CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor PLoS ONE, 2019;14(9):e0222779. 2019 [PMID: 31536596] (Bioassay, Human)
• S Akbari, GG Sevinç, N Ersoy, O Basak, K Kaplan, K Sevinç, E Ozel, B Sengun, E Enustun, B Ozcimen, A Bagriyanik, N Arslan, TT Önder, E Erdal Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling Stem Cell Reports, 2019;13(4):627-641. 2019 [PMID: 31522975] (Cell Culture, Human)
• AG Hawkins, CM Julian, S Konzen, S Treichel, ER Lawlor, KM Bailey Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma Neoplasia, 2019;21(10):1063-1072. 2019 [PMID: 31521948] (Bioassay, Human)
• Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu Controlled modelling of human epiblast and amnion development using stem cells Nature, 2019;573(7774):421-425. 2019 [PMID: 31511693] (Bioassay, Human)
• C Praça, SC Rosa, E Sevin, R Cecchelli, MP Dehouck, LS Ferreira Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells Stem Cell Reports, 2019;13(4):599-611. 2019 [PMID: 31495714] (Bioassay, Human)
• CP Nielsen, KK Jernigan, NL Diggins, DJ Webb, JA MacGurn USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification Cell Rep, 2019;28(4):1074-1089.e5. 2019 [PMID: 31340145] (Cell Culture, Human)
• T Wang, P Nimkingrat, CA Smith, A Cheng, TE Hardingham, SJ Kimber Enhanced chondrogenesis from human embryonic stem cells Stem Cell Res, 2019;39(0):101497. 2019 [PMID: 31326745] (Bioassay, Human)
• Y Wen, H Yang, J Wu, A Wang, X Chen, S Hu, Y Zhang, D Bai, Z Jin COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells Theranostics, 2019;9(15):4265-4286. 2019 [PMID: 31285761] (Cell Culture, Human)
• KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 2019;8(7):. 2019 [PMID: 31277507] (Bioassay, Human)
• KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells J Clin Med, 2019;8(7):. 2019 [PMID: 31277507] (Bioassay, Human)
• Z Yan, K Ohuchida, S Fei, B Zheng, W Guan, H Feng, S Kibe, Y Ando, K Koikawa, T Abe, C Iwamoto, K Shindo, T Moriyama, K Nakata, Y Miyasaka, T Ohtsuka, K Mizumoto, M Hashizume, M Nakamura Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis J. Exp. Clin. Cancer Res., 2019;38(1):221. 2019 [PMID: 31133044] (Bioassay, Human)
• K Abe, A Shimada, S Tayama, H Nishikawa, T Kaneko, S Tsuda, A Karaiwa, T Matsui, T Ishitani, H Takeda Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite Cell Rep, 2019;27(3):928-939.e4. 2019 [PMID: 30995487] (In Vivo, Fish - Oryzias latipes (Medaka/Rice Fish))
• K Kaiser, D Gyllborg, J Procházka, A Salašová, P Kompaníkov, FL Molina, R Laguna-Goy, T Radaszkiew, J Harnoš, M Procházkov, D Pot?šil, RA Barker, ÁG Casado, Z Zdráhal, R Sedlá?ek, E Arenas, JC Villaescus, V Bryja WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis Nat Commun, 2019;10(1):1498. 2019 [PMID: 30940800] (Bioassay, Mouse)
• X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert Point mutations in the PDX1 transactivation domain impair human ?-cell development and function Mol Metab, 2019;0(0):. 2019 [PMID: 30930126] (Human)
• O Lyros, AK Lamprecht, L Nie, R Thieme, K Götzel, M Gasparri, G Haasler, P Rafiee, R Shaker, I Gockel Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett&#039;s associated esophageal adenocarcinoma Am J Cancer Res, 2019;9(2):330-346. 2019 [PMID: 30906632] (Bioassay, Human)
• P Shooshtari, A Helness, C Vadnais, N Brouwer, H Beauchemin, R Chen, H Bagci, FJT Staal, JF Coté, T Möröy Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes Nat Commun, 2019;10(1):1270. 2019 [PMID: 30894540] (Bioassay, Human)
• K Götzel, O Chemnitzer, L Maurer, A Dietrich, U Eichfeld, O Lyros, Y Moulla, S Niebisch, M Mehdorn, B Jansen-Win, M Vieth, A Hoffmeiste, I Gockel, R Thieme In-depth characterization of the Wnt-signaling/?-catenin pathway in an in vitro model of Barrett&#039;s sequence BMC Gastroenterol, 2019;19(1):38. 2019 [PMID: 30841855] (Bioassay, Human)
• T Colunga, M Hayworth, S Kre beta, DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 2019;26(10):2566-2579.e10. 2019 [PMID: 30840882] (Bioassay, Human)
• H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 2019;13(0):243-252. 2019 [PMID: 30828587] (Bioassay, Human)
• V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed Excess growth hormone suppresses DNA damage repair in epithelial cells JCI Insight, 2019;4(3):. 2019 [PMID: 30728323] (Bioassay, Human)
• X Yu, M Wang, J Wu, Q Han, X Zhang ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway J. Exp. Clin. Cancer Res., 2019;38(1):40. 2019 [PMID: 30691485] (Bioassay, Human)
• L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 2019;10(1):364. 2019 [PMID: 30664750] (Bioassay, Human)
• KE Worley, AS Chin, LQ Wan Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation Stem Cells Int, 2018;2018(0):1848605. 2018 [PMID: 30627170] (Bioassay, Human)
• C Bonamy, E Sechet, A Amiot, A Alam, M Mourez, L Fraisse, PJ Sansonetti, B Sperandio Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells Sci Rep, 2018;8(1):18043. 2018 [PMID: 30575780] (Bioassay, Human)
• A Ogorodniko, M Levin, S Tattikota, S Tokalov, M Hoque, D Scherzinge, F Marini, A Poetsch, H Binder, S Macher-Göp, HC Probst, B Tian, M Schaefer, KJ Lackner, F Westermann, S Danckwardt Transcriptome 3&#039;end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma Nat Commun, 2018;9(1):5331. 2018 [PMID: 30552333] (Bioassay, Human)
• BA Brown, GM Connolly, CEJ Mill, H Williams, GD Angelini, JL Johnson, SJ George Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells Aging Cell, 2018;0(0):e12844. 2018 [PMID: 30548452] (Bioassay, Mouse)
• J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family PLoS ONE, 2018;13(12):e0208110. 2018 [PMID: 30540809] (Bioassay, Human)
• T Kijima, H Nakagawa, M Shimonoson, PM Chandramou, T Hara, V Sahu, Y Kasagi, O Kikuchi, K Tanaka, V Giroux, AB Muir, KA Whelan, S Ohashi, S Naganuma, AJ Klein-Szan, Y Shinden, K Sasaki, I Omoto, Y Kita, M Muto, AJ Bass, JA Diehl, GG Ginsberg, Y Doki, M Mori, Y Uchikado, T Arigami, NG Avadhani, D Basu, AK Rustgi, S Natsugoe Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells Cell Mol Gastroenterol Hepatol, 2019;7(1):73-91. 2019 [PMID: 30510992] (Bioassay, Human)
• R Diacou, Y Zhao, D Zheng, A Cvekl, W Liu Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation Cell Rep, 2018;25(9):2510-2523.e4. 2018 [PMID: 30485816] (Bioassay, Mouse)
• Q Peng, L Chen, W Wu, J Wang, X Zheng, Z Chen, Q Jiang, J Han, L Wei, L Wang, J Huang, J Ma EPH receptor A2 governs a feedback loop that activates Wnt/?-catenin signaling in gastric cancer Cell Death Dis, 2018;9(12):1146. 2018 [PMID: 30451837] (Bioassay, Human)
• K Jeon, D Kumar, AE Conway, K Park, R Jothi, AM Jetten GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors Stem Cells, 2018;0(0):. 2018 [PMID: 30376208] (Immunoassay Development, Human)
• H Ida, T Akiyama, K Ishiguro, SK Goparaju, Y Nakatake, N Chikazawa-, S Sato, H Kimura, Y Yokoyama, M Nagino, MSH Ko, SBH Ko Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors Stem Cell Res Ther, 2018;9(1):277. 2018 [PMID: 30359326] (Bioassay, Human)
• B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling Cell Rep, 2018;25(3):571-584.e5. 2018 [PMID: 30332639] (Bioassay, Human)
• E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3 Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 30275324] (Bioassay, Human)
• S Yamada, Y Kubo, D Yamazaki, Y Sekino, Y Nomura, S Yoshida, Y Kanda Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells Sci Rep, 2018;8(1):12155. 2018 [PMID: 30108368] (Bioassay, Human)
• E Magro-Lope, C Palmer, J Manso, I Liste, A Zambrano Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids Stem Cell Res Ther, 2018;9(1):186. 2018 [PMID: 29996941] (Bioassay, Human)
• Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 2018;0(0):2352-345X. 2018 [PMID: 29930984] (Bioassay, Human)
• MJ Workman, JP Gleeson, EJ Troisi, HQ Estrada, SJ Kerns, CD Hinojosa, GA Hamilton, SR Targan, CN Svendsen, RJ Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips Cell Mol Gastroenterol Hepatol, 2018;5(4):669-677.e2. 2018 [PMID: 29930984] (Bioassay, Human)
• Y Zhao, C Wang, C Wang, X Hong, J Miao, Y Liao, L Zhou, Y Liu An essential role for Wnt/?-catenin signaling in mediating hypertensive heart disease Sci Rep, 2018;8(1):8996. 2018 [PMID: 29895976] (Bioassay, Rat)
• M Russo, S Lamba, A Lorenzato, A Sogari, G Corti, G Rospo, B Mussolin, M Montone, L Lazzari, S Arena, D Oddo, M Linnebache, A Sartore-Bi, F Pietranton, S Siena, F Di Nicolan, A Bardelli Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies Nat Commun, 2018;9(1):2287. 2018 [PMID: 29895949] (Bioassay, Human)
• J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018;0(0):9636897187803. 2018 [PMID: 29895168] (Bioassay, Human)
• D Garnier, R Li, F Delbos, A Fourrier, C Collet, C Guguen-Gui, C Chesné, TH Nguyen Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system Sci Rep, 2018;8(1):8222. 2018 [PMID: 29844473] (Bioassay, Human)
• A Sarkar, A Mei, ACM Paquola, S Stern, C Bardy, JR Klug, S Kim, N Neshat, HJ Kim, M Ku, MN Shokhirev, DH Adamowicz, MC Marchetto, R Jappelli, JA Erwin, K Padmanabha, M Shtrahman, X Jin, FH Gage Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In�Vitro Cell Stem Cell, 2018;22(5):684-697.e9. 2018 [PMID: 29727680] (Bioassay, Human)
• BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao A20 regulates canonical wnt-signaling through an interaction with RIPK4 PLoS ONE, 2018;13(5):e0195893. 2018 [PMID: 29718933] (Bioassay, Human)
• HK Lee, EW Lee, J Seo, M Jeong, SH Lee, SY Kim, EH Jho, CH Choi, JY Chung, J Song Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/?-catenin signaling Oncogene, 2018;0(0):. 2018 [PMID: 29713058] (Bioassay, Human)
• M Amin, Y Kushida, S Wakao, M Kitada, K Tatsumi, M Dezawa Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype Cell Transplant, 2018;27(2):285-298. 2018 [PMID: 29637816] (Bioassay, Human)
• H He, F Du, Y He, Z Wei, C Meng, Y Xu, H Zhou, N Wang, XG Luo, W Ma, TC Zhang The Wnt-?-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells Oncotarget, 2018;9(20):15239-15251. 2018 [PMID: 29632640] (Bioassay, Human)
• XG Li, Z Wang, RQ Chen, HL Fu, CQ Gao, HC Yan, GX Xing, XQ Wang LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/?-Catenin Signaling Int J Mol Sci, 2018;19(4):. 2018 [PMID: 29601474] (Bioassay, Porcine)
• HJ Lee, J Li, RE Vickman, J Li, R Liu, A Durkes, BD Elzey, S Yue, X Liu, TL Ratliff, JX Cheng Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway Mol. Cancer Res., 2018;0(0):. 2018 [PMID: 29545473] (Bioassay, Human)
• S Condello, LE Sima, C Ivan, H Cardenas, GE Schiltz, RK Mishra, D Matei Tissue transglutaminase regulates interactions between ovarian cancer stem cells and the tumor niche Cancer Res., 2018;0(0):. 2018 [PMID: 29510995] (Bioassay, Human)
• M Szemes, A Greenhough, Z Melegh, S Malik, A Yuksel, D Catchpoole, K Gallacher, M Kollareddy, JH Park, K Malik Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma Neoplasia, 2018;20(4):335-350. 2018 [PMID: 29505958] (Bioassay, Human)
• S Kokabu, V Rosen BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling FEBS Open Bio, 2018;8(2):168-176. 2018 [PMID: 29435407] (Bioassay, Mouse)
• J Gillespie, RL Ross, C Corinaldes, F Esteves, E Derrett-Sm, MF McDermott, GM Doody, CP Denton, P Emery, F Del Galdo TGF? activation primes canonical Wnt signaling through the downregulation of AXIN2 Arthritis & rheumatology (Hoboken, N.J.), 2018;0(0):. 2018 [PMID: 29409120] (Cell Culture, Human)
• X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert Genome-wide analysis of PDX1 target genes in human pancreatic progenitors Mol Metab, 2018;0(0):. 2018 [PMID: 29396371] (Bioassay, Human)
• S Lamprecht, M Kaller, EM Schmidt, C Blaj, TS Schiergens, J Engel, A Jung, H Hermeking, TGP Grünewald, T Kirchner, D Horst PBX3 is part of an EMT regulatory network and indicates poor outcome in colorectal cancer Clin. Cancer Res., 2018;0(0):. 2018 [PMID: 29391352] (Stimulation, Human)
• AG Hawkins, V Basrur, F da Veiga L, E Pedersen, C Sperring, AI Nesvizhski, ER Lawlor The Ewing sarcoma secretome and its response to activation of Wnt/beta-catenin signaling Mol. Cell Proteomics, 2018;0(0):. 2018 [PMID: 29386236] (Human)
• Y Sui, Z Liu, SH Park, SE Thatcher, B Zhu, JP Fernandez, H Molina, PA Kern, C Zhou IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation JCI Insight, 2018;3(2):. 2018 [PMID: 29367460] (Bioassay, Mouse)
• Q Li, Q Wang, O Wang, K Shao, H Lin, Y Lei A simple and scalable hydrogel-based system for culturing protein-producing cells PLoS ONE, 2018;13(1):e0190364. 2018 [PMID: 29293594] (Bioassay, Human)
• DS Varghese, S Parween, MT Ardah, BS Emerald, SA Ansari Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro Stem Cells Int, 2017;2017(0):2451927. 2017 [PMID: 29147115] (Bioassay, Human)
• V Uribe-Etxe, J Luzuriaga, P García-Gal, A Agliano, F Unda, G Ibarretxe Notch/Wnt cross-signalling regulates stemness of dental pulp stem cells through expression of neural crest and core pluripotency factors Eur Cell Mater, 2017;34(0):249-270. 2017 [PMID: 29092089] (Bioassay, Human)
• SJ Zhao, YQ Jiang, NW Xu, Q Li, Q Zhang, SY Wang, J Li, YH Wang, YL Zhang, SH Jiang, YJ Wang, YJ Huang, XX Zhang, GA Tian, CC Zhang, YY Lv, M Dai, F Liu, R Zhang, D Zhou, ZG Zhang SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/?-catenin signaling through stabilization of the WNT-receptor complex Oncogene, 2017;0(0):. 2017 [PMID: 29084211] (Bioassay, Human)
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• Jin R, Liu W, Menezes S, Yue F, Zheng M, Kovacevic Z, Richardson D The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4. J Cell Sci, 2014;127(0):3116-30. 2014 [PMID: 24829151] (Bioassay, Human)
• Peng X, Yang L, Chang H, Dai G, Wang F, Duan X, Guo L, Zhang Y, Chen G Wnt/beta-catenin signaling regulates the proliferation and differentiation of mesenchymal progenitor cells through the p53 pathway. PLoS ONE, 2014;9(5):e97283. 2014 [PMID: 24819053] (Bioassay, Human)
• Hinton A, Hunter S, Afrikanova I, Jones G, Lopez A, Fogel G, Hayek A, King C sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells, 2014;32(9):2360-72. 2014 [PMID: 24805944] (Bioassay, Human)
• Fuerer C, Nostro M, Constam D Nodal.Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation. J Biol Chem, 2014;289(25):17854-71. 2014 [PMID: 24798330] (Bioassay, Human)
• Kang, Minyong, Kim, Hyeon Ho, Han, Yong-Mah Generation of bladder urothelium from human pluripotent stem cells under chemically defined serum- and feeder-free system. Int J Mol Sci, 2014;15(5):7139-57. 2014 [PMID: 24776760] (Bioassay, Human)
• Hillesheim A, Nordhoff C, Boergeling Y, Ludwig S, Wixler V beta-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-kappaB signaling. Cell Commun Signal, 2014;12(0):29. 2014 [PMID: 24767605] (Bioassay, Human)
• Ekstrom E, Bergenfelz C, von Bulow V, Serifler F, Carlemalm E, Jonsson G, Andersson T, Leandersson K WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer, 2014;13(0):88. 2014 [PMID: 24766647] (Bioassay, Human)
• Tsai T, Shih S, Ho T, Ma H, Liu M, Chen S, Tsao Y Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor. PLoS ONE, 2014;9(4):e95443. 2014 [PMID: 24763086] (Bioassay, Rat)
• Emmrich S, Rasche M, Schoning J, Reimer C, Keihani S, Maroz A, Xie Y, Li Z, Schambach A, Reinhardt D, Klusmann J miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFbeta and Wnt signaling. Genes Dev, 2014;28(8):858-74. 2014 [PMID: 24736844] (Bioassay, Human)
• Kang, Minyong, Han, Yong-Mah Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system. PLoS ONE, 2014;9(4):e94888. 2014 [PMID: 24728509] (Bioassay, Human)
• Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. PLoS ONE, 2014;9(4):e92273. 2014 [PMID: 24710173] (Bioassay, Human)
• Chen E, DeRan M, Ignatius M, Grandinetti K, Clagg R, McCarthy K, Lobbardi R, Brockmann J, Keller C, Wu X, Langenau D Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A, 2014;111(14):5349-54. 2014 [PMID: 24706870] (Bioassay, Human)
• Cnossen W, te Morsche R, Hoischen A, Gilissen C, Chrispijn M, Venselaar H, Mehdi S, Bergmann C, Veltman J, Drenth J Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis. Proc Natl Acad Sci U S A, 2014;111(14):5343-8. 2014 [PMID: 24706814]
• Carmon K, Gong X, Yi J, Thomas A, Liu Q RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A, 2014;111(13):E1221-9. 2014 [PMID: 24639526] (Bioassay, Human)
• Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 2014;14(3):342-56. 2014 [PMID: 24607406] (Bioassay, Human)
• Meinhardt G, Haider S, Haslinger P, Proestling K, Fiala C, Pollheimer J, Knofler M Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology, 2014;155(5):1908-20. 2014 [PMID: 24605829] (Bioassay, Human)
• Guezguez A, Pare F, Benoit Y, Basora N, Beaulieu J Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res, 2014;322(2):355-64. 2014 [PMID: 24534551] (Bioassay, Human)
• Lin, I-Ying, Chiu, Feng-Lan, Yeang, Chen-Hsi, Chen, Hsin-Fu, Chuang, Ching-Yu, Yang, Shii-Yi, Hou, Pei-Shan, Sintupisut, Nardnisa, Ho, Hong-Ner, Kuo, Hung-Chi, Lin, Kuo-I Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells. Stem Cell Reports, 2014;2(2):189-204. 2014 [PMID: 24527393] (Bioassay, Human)
• Wu C, Qiu S, Lu L, Zou J, Li W, Wang O, Zhao H, Wang H, Tang J, Chen L, Xu T, Sun Z, Liao W, Luo G, Lu X RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer. Nat Commun, 2014;5(0):3149. 2014 [PMID: 24476626]
• van den Bosch M, Blom A, van Lent P, van Beuningen H, Blaney Davidson E, van der Kraan P, van den Berg W Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell Signal, 2014;26(5):951-8. 2014 [PMID: 24463008] (Bioassay, Human)
• Aloia L, Di Stefano B, Sessa A, Morey L, Santanach A, Gutierrez A, Cozzuto L, Benitah S, Graf T, Broccoli V, Di Croce L Zrf1 is required to establish and maintain neural progenitor identity. Genes Dev, 2014;28(2):182-97. 2014 [PMID: 24449271] (Bioassay, Human)
• Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, Pourasgari F, Hajarizadeh A, Soleimani M, Nabiuni M, Khorramizadeh M Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells. Exp Cell Res, 2014;322(1):51-61. 2014 [PMID: 24434355] (Bioassay, Human)
• Dhamdhere, Girija R, Fang, Mark Y, Jiang, Jie, Lee, Katherin, Cheng, Du, Olveda, Rebecca, Liu, Bo, Mulligan, Kimberle, Carlson, Jeffery, Ransom, Ryan C, Weis, William, Helms, Jill A Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS ONE, 2014;9(1):e83650. 2014 [PMID: 24400074] (Bioassay, Human)
• Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells. Stem Cells Transl Med, 2014;3(3):277-89. 2014 [PMID: 24375542] (Bioassay, Human)
• Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol, 2014;25(6):1211-25. 2014 [PMID: 24357672] (Bioassay, Human)
• Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports, 2013;1(4):293-306. 2013 [PMID: 24319665] (Bioassay, Human)
• Listerman I, Gazzaniga F, Blackburn E An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells. Mol Cell Biol, 2014;34(2):280-9. 2014 [PMID: 24216762] (Bioassay, Human)
• Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H IQGAP1 protein regulates nuclear localization of beta-catenin via importin-beta5 protein in Wnt signaling. J Biol Chem, 2013;288(51):36351-60. 2013 [PMID: 24196961] (Cell Culture, Human)
• Jiang Y, Dai J, Zhang H, Sottnik J, Keller J, Escott K, Sanganee H, Yao Z, McCauley L, Keller E Activation of the Wnt pathway through AR79, a GSK3beta inhibitor, promotes prostate cancer growth in soft tissue and bone. Mol Cancer Res, 2013;11(12):1597-610. 2013 [PMID: 24088787]
• Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells. Stem Cells Dev, 2014;23(4):372-9. 2014 [PMID: 24083371] (Bioassay, Human)
• Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells, 2013;31(11):2432-42. 2013 [PMID: 23897760] (Bioassay, Human)
• Rasmussen N, Wright T, Brooks S, Hacker K, Debebe Z, Sendor A, Walker M, Major M, Green J, Wahl G, Rathmell W Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer. J Biol Chem, 2013;288(36):26301-10. 2013 [PMID: 23893409] (Bioassay, Human)
• Loh Y, Hedditch E, Baker L, Jary E, Ward R, Ford C The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer, 2013;13(0):174. 2013 [PMID: 23547709] (Bioassay, Human)
• Hernandez-Maqueda J, Luna-Ulloa L, Santoyo-Ramos P, Castaneda-Patlan M, Robles-Flores M Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines. PLoS ONE, 2013;8(3):e58540. 2013 [PMID: 23520519] (Bioassay, Human)
• Greer Y, Fields A, Brown A, Rubin J Atypical protein kinase Ciota is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem, 2013;288(13):9438-46. 2013 [PMID: 23396968] (Bioassay, Human)
• Tahir S, Yang G, Goltsov A, Song K, Ren C, Wang J, Chang W, Thompson T Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer. Cancer Res, 2013;73(6):1900-11. 2013 [PMID: 23302227] (Bioassay, Human)
• Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther, 2013;21(1):228-39. 2013 [PMID: 23183535] (Bioassay, Human)
• Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal, 2013;25(1):178-89. 2013 [PMID: 23022962] (Bioassay, Human)
• Sui L, Mfopou J, Geens M, Sermon K, Bouwens L FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun, 2012;426(3):380-5. 2012 [PMID: 22960178] (Bioassay, Human)
• Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems. Biol Reprod, 2012;87(4):79. 2012 [PMID: 22811575] (Bioassay, Bovine)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012;487(7408):505-9. 2012 [PMID: 22763448] (Bioassay, Human)
• Cohen E, Miller M, Wang Z, Moon R, Morrisey E Wnt5a and Wnt11 are essential for second heart field progenitor development. Development, 2012;139(11):1931-40. 2012 [PMID: 22569553] (Bioassay, Mouse)
• Erceg S, Lukovic D, Moreno-Manzano V, Stojkovic M, Bhattacharya S Derivation of cerebellar neurons from human pluripotent stem cells. Curr Protoc Stem Cell Biol, 2012;20(0):1H.51. 2012 [PMID: 22415839] (Bioassay, Human)
• Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant, 2012;21(6):1321-39. 2012 [PMID: 22195604] (Cell Culture, Human)
• Ichii, Michiko, Frank, Mark Bar, Iozzo, Renato V, Kincade, Paul W The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood, 2012;119(7):1683-92. 2012 [PMID: 22117039] (Bioassay, Human)
• Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J. Bone Miner. Res., 2011;26(9):2082-95. 2011 [PMID: 21638320] (Bioassay, Human)
• Spence JR, Mayhew CN, Rankin SA Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 2011;470(7332):105-9. 2011 [PMID: 21151107] (Bioassay, Human)
• Kohler EE, Cowan CE, Chatterjee I NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood, 2011;117(5):1761-9. 2011 [PMID: 21119109] (Bioassay, Human)
• Gudjonsson JE, Johnston A, Stoll SW Evidence for altered Wnt signaling in psoriatic skin. J. Invest. Dermatol., 2010;130(7):1849-59. 2010 [PMID: 20376066] (Bioassay, Human)
• Liu G, Vijayakumar S, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson SA Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J. Cell Biol., 2009;185(1):67-75. 2009 [PMID: 19349579] (Bioassay, Human)

Bioinformatics

• Gene Symbol: WNT3A
• Uniprot:
  • NP_149122(Human)