This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated.
Source
Wheat germ
Protein/Peptide Type
Recombinant Protein
Gene
NR5A2
Purity
>80% by SDS-PAGE and Coomassie blue staining
Applications/Dilutions
Dilutions
ELISA
Immunoaffinity Purification
Protein Array
Western Blot
Theoretical MW
82.9 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Preservative
No Preservative
Purity
>80% by SDS-PAGE and Coomassie blue staining
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Recombinant Human LRH-1/NR5A2 GST (N-Term) Protein
Alpha-1-fetoprotein transcription factor
B1-binding factor
b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus
B1F
B1F2
fetoprotein-alpha 1 (AFP) transcription factor
FTFLRH1
FTZ-F1 beta
FTZ-F1
FTZ-F1beta
HB1F
hB1F-2
hB1FCYP7A promoter-binding factor
Hepatocytic transcription factor
Liver receptor homolog 1
liver receptor homolog-1
LRH1
LRH-1
LRH-1CPF
NR5A2
nuclear receptor NR5A2
nuclear receptor subfamily 5 group A member 2
nuclear receptor subfamily 5, group A, member 2
Background
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
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