LRH-1/NR5A2 Products

Description

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

Bioinformatics

Uniprot	NP_995582 Human O00482 Human NP_003813 Human NP_003813.1 Human
Product By Gene ID	2494
Alternate Names	HB1F Liver receptor homolog 1 B1-binding factor Hepatocytic transcription factor nuclear receptor subfamily 5 group A member 2 Alpha-1-fetoprotein transcription factor nuclear receptor NR5A2 hB1F-2 liver receptor homolog-1 FTZ-F1beta fetoprotein-alpha 1 (AFP) transcription factor FTZ-F1 b1-binding factor, hepatocyte transcription factor which activates enhancer IIof hepatitis B virus B1F2 FTFLRH1 hB1FCYP7A promoter-binding factor LRH-1CPF B1F nuclear receptor subfamily 5, group A, member 2

Diseases related to LRH-1/NR5A2

Discover more about diseases related to LRH-1/NR5A2.

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Pituitary Diseases
Carcinoma
Mammary Neoplasms
Hepatitis B
Hepatitis
Liver Carcinoma
Inflammation
Cell Transformation, Neoplastic
Malignant Neoplasm Of Pancreas
Pancreatic Neoplasm
Adenocarcinoma
Liver Diseases
Insulin Resistance
Liver Neoplasms
Carcinogenesis
Diabetes Mellitus
Infertility

Pathways for LRH-1/NR5A2

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Cholesterol Homeostasis
Transport
Cell Proliferation
Cell Differentiation
Localization
Cholesterol Transport
Reverse Cholesterol Transport
Rna Interference
Ovulation
Cell Cycle
Secretion
Pathogenesis
Granulosa Cell Differentiation
Regulation Of Gene Expression
Conjugation
Lipid Homeostasis
Regeneration
Glycolysis
Inflammatory Response
Gastrulation

Research Areas for LRH-1/NR5A2

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Chromatin Research
Neuroscience

PTMs for LRH-1/NR5A2

Learn more about PTMs related to LRH-1/NR5A2.

Cleavage
Sumoylation
Phosphorylation
Acetylation
Demethylation
Methylation
Deacetylation

Bioinformatics Tool for LRH-1/NR5A2

Discover related pathways, diseases and genes to LRH-1/NR5A2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.