LPP Antibody (691121) [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 691121
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

LPP Antibody (691121) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human LPP
  Lys138-Gln261
  Accession # Q93052
• Specificity: Detects human LPP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human TRIP-4, -6, or -11 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LPP Antibody (691121) [Alexa Fluor® 350]

• DKFZp779O0231
• FLJ30652
• FLJ41512
• LIM domain containing preferred translocation partner in lipoma
• LIM domain-containing preferred translocation partner in lipoma
• LIM protein
• lipoma-preferred partner
• LPP

Background

Human LIM domain-containing preferred translocation partner in lipoma (LPP) is an 80 kDa intracellular protein that contains an N-terminal Pro-rich region (aa 41-370) followed by three tandem LIM domains (aa 414-603). It localizes to focal adhesion plaques where it regulates junction assembly and cytoskeleton remodeling through interactions with a-Actinin, VASP, SCRIB, Supervillin, and Palladin. In the nucleus, LPP coactivates the transcription factor PEA3 and protects telomeres from DNA damage. LPP is a frequent target of chromosomal translocations with HMG-A2 in lipoma. Within aa 138-261, human LPP shares 90% and 77% aa sequence identity with mouse and rat LPP, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.